Camalexin |
| Catalog No.GC18922 |
Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135531-86-1
Sample solution is provided at 25 µL, 10mM.
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Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection. In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines. Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM). Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9. In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.
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Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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