Innate Immunity
Produkte für Innate Immunity
- Bestell-Nr. Artikelname Informationen
- GC18602 p38 MAPK Inhibitor IV p38 MAPK Inhibitor IV ist ein hochspezifisches ATP-kompetitives p38α MAPK-Inhibitor mit IC50s von 0,13 und 0,55 μ M fÜr p38α und p38β MAPK bzw.
- GC52342 P4pal10 (trifluoroacetate salt) A PAR4 and FPR2 antagonist and an FFAR2 agonist
- GC44540 PAF C-16 Carboxylic Acid PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.
- GC47855 PAF C-16-d4 An internal standard for the quantification of PAF C16
- GC44541 PAF C-18 PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.
- GC41450 PAF C-18:1 PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response.
- GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC49061 Pam2CSK4 (trifluoroacetate salt) A bacterial lipopeptide and TLR2 agonist
- GC49422 PAR2 (1-6) amide (human) (trifluoroacetate salt) A peptide agonist of PAR2
- GC44579 PCTR1 PCTR1 ist ein potenter Monozyten-/Makrophagen-Agonist, der wichtige entzÜndungshemmende und pro-auflÖsende Prozesse wÄhrend einer bakteriellen Infektion reguliert.
- GC44580 PCTR2 Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.
- GC44581 PCTR3 Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid.
- GC47931 PDE4B Inhibitor A PDE4B inhibitor
- GC44590 Pellitorine Pellitorin ist eine Verbindung, die aus den Wurzeln von Piper nigrum isoliert wird. Pellitorin zeigt starke zytotoxische AktivitÄten gegen HL60- und MCT-7-Zelllinien. Pellitorine hat das Potenzial fÜr die Erforschung von Krebserkrankungen.
- GC52127 Pexiganan (acetate)
- GC44633 Phosphatidylserines (bovine) Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.
- GC18522 Phosphatidylserines (sodium salt) Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.
- GC49265 PKI (14-22) amide (myristoylated) (trifluoroacetate salt) A PKA inhibitor
- GC47963 Plerixafor-d4 An internal standard for the quantification of plerixafor
- GC47964 pNPS-DHA An anti-allergic DHEA derivative
- GC52270 Pranoprofen-13C-d3 An internal standard for the quantification of pranoprofen
- GC48501 Preterramide C Preterramid C ist ein Pilzmetabolit.
- GC41170 Prostaglandin D2 methyl ester Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.
- GC47988 Prostaglandin D2-d4 An internal standard for the quantification of prostaglandin D2
- GC40981 Protectin D1 Protectin D1, Neuroprotectin D1, wenn es von neuralen Zellen erzeugt wird, ist ein Mitglied einer neuen Familie bioaktiver Produkte, die aus DocosahexaensÄure erzeugt werden.
- GC48993 Protectin D1-d5 An internal standard for the quantification of protectin D1
- GC44794 Pyrrophenone Pyrrophenon ist ein potenter und spezifischer Hemmer der zytosolischen Phospholipase A2α (cPLA2α) mit einem IC50-Wert von 4,2 nM.
- GC40004 Quinolactacin A Chinolactacin A ist ein Inhibitor der TNF-Produktion.
- GC44802 R-8507 R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).
- GC48461 rac-trans-4-hydroxy Glyburide An active metabolite of glyburide
- GC48035 RCTR1 A specialized pro-resolving mediator
- GC41231 Resolvin D2 methyl ester Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase.
- GC49279 Resolvin D2 n-3 DPA A specialized pro-resolving mediator
- GC48042 Resolvin D2-d5 An internal standard for the quantification of RvD2
- GC41232 Resolvin D3 methyl ester Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.
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GC44818
Resolvin D4
Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.
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GC40982
Resolvin D5
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
- GC48972 Resolvin E2 A specialized pro-resolving mediator
- GC48045 Resolvin E4 A specialized pro-resolving mediator
- GC44820 Resveratrol-3-O-Sulfate (sodium salt) Resveratrol-3-O-sulfat (Natrium) ist der Metabolit von Resveratrol.
- GC41189 Ricinelaidic Acid Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes).
- GC44839 Ridaifen-B An analog of tamoxifen
- GC48048 Rifampicin-d3 An internal standard for the quantification of rifampicin
- GC44851 Rosiglitazone (potassium salt) Rosiglitazon (BRL 49653)-Kalium ist ein oral aktives selektives PPARγ Agonist (EC50: 60 nM, Kd: 40 nM).
- GC48059 Rosiglitazone-d3 An internal standard for the quantification of rosiglitazone
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GC41626
Sappanone A
Sappanone A ist eine Homoisoflavanon mit starken antioxidativen und entzündungshemmenden Eigenschaften.
- GC46221 Seselin An angular pyranocoumarin with diverse biological activities
- GC18821 SGA360 SGA360 unterdrÜckt die entzÜndliche SAA1-Signalgebung auf AHR-abhÄngige Weise durch einen Mechanismus, der keine AHR-Bindung an sein zugehÖriges Response-Element (partieller Antagonist) erfordert.
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GC49333
SH-42
Ein Hemmstoff von DHCR24
- GC49002 Sinigrin (hydrate) Sinigrin (Hydrat) ist ein natürliches aliphatisches Glucosinolat, das in Pflanzen der Familie Brassicaceae vorkommt.
- GC49049 SMU127 An agonist of TLR1/2
- GC49400 SN-011 SN-011 ist ein potenter und selektiver Maus- und Human-STING-Inhibitor mit einem IC50-Wert von 76 nM fÜr die STING-Signalgebung.
- GC44910 Sodium Hydrogen Sulfide (hydrate) Hydrogen sulfide (H2S) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals.
- GC44919 SP 600125, negative control SP 600125 is a selective, cell-permeable, reversible inhibitor of JNK isoforms 1-3 with Ki values of 0.19 μM.
- GC44930 Sphingosine (d14:1) Sphingosin (d14:1) (Tetradecasphing-4-enin), ein Sphingolipid, ist ein potenter Proteinkinase C (PKC)-Inhibitor. Sphingosin (d14:1) verhindert seine Wechselwirkung mit sn-1,2-Diacylglycerol (DAG)/Phorbol-Estern.
- GC48098 SR 12343 An IKKβ NBD mimetic
- GC48099 SR 12460 An IKKβ NBD mimetic
- GC45567 SR 1903
- GC61293 SR-717 SR-717 ist ein Nicht-Nukleotid-STING-Agonist mit EC50-Werten von 2,1 μM und 2,2 μM in ISG-THP1 (WT)- bzw. ISG-THP1 cGAS KO (cGAS KO)-Zelllinien.
- GC45831 SRI-011381 SRI-011381 ist ein oral aktiver TGF-β-Signalagonist mit neuroprotektiven Wirkungen.
- GC40922 SRS11-92 SRS11-92, ein Ferrostatin-1 (Fer-1)-Analogon, ist ein potenter Ferroptose-Hemmer.
- GC44948 StA-IFN-1 StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1, which specifically inhibits the IKKβ component of the IFN induction pathway.
- GC49844 Stercobilin (hydrochloride) A fecal pigment and metabolite of bilirubin
- GC48109 STING Agonist 12b A STING agonist
- GC48110 STING Agonist 1a STING-Agonist 1a (1a) ist ein spezifischer Stimulator von Interferon-Genen (STING)-Agonist.
- GC45570 STING Agonist C11
- GC46227 STING18 A competitive STING ligand
- GC44956 Streptochlorin Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp.
- GC52496 Sulfatide (bovine) (sodium salt) A mixture of isolated bovine sulfatides
- GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
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GC18453
Sulochrin
Sulochrin ist ein von A. produziertes Pilzmetabolit.
- GC48764 Sydowinin B A xanthone polyketide with immunosuppressant activity
- GC49047 T-5342126 A TLR4 antagonist
- GC48447 TAS 205 An inhibitor of H-PGDS
- GC44999 Tauro-α-muricholic Acid (sodium salt) Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid.
- GC45004 TC 14012 (trifluoroacetate salt) C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12).
- GC49105 Tebipenem (hydrate) A carbenapenem antibiotic
- GC45012 Tenofovir diphosphate (sodium salt) Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM).
- GC49386 Tepoxalin Tepoxalin ist ein dualer Inhibitor von COX und 5-Lipoxygenase (5-LO) mit starker entzÜndungshemmender Wirkung und einem gÜnstigen gastrointestinalen Profil.
- GC40627 tetranor-Misoprostol tetranor-Misoprostol is a metabolite of misoprostol.
- GC19001 Tetromycin B Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively.
- GC45030 TG6-129 TG6-129 ist ein selektiver Antagonist des EP2-Rezeptors.
- GC48163 Theophylline-d6 Theophyllin-d6 (1,3-Dimethylxanthine-d6) ist das mit Deuterium bezeichnete Theophyllin. Theophyllin ist ein nichtselektiver Phosphodiesterase (PDE)-Hemmer, Adenosinrezeptorblocker und Histon-Deacetylase (HDAC)-Aktivator.
- GC49503 Thujopsene A sesquiterpene with diverse biological activities
- GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) An actin-sequestering peptide
- GC49062 Tiopronin-d3 Tiopronin-d3 ist das mit Deuterium bezeichnete Tiopronin.
- GC45057 TIQ-A TIQ-A ist ein potenter TNKS (Poly-ART, PARP)-Inhibitor mit einem IC50-Wert von 24 nM fÜr TNKS2.
- GC45965 Tolfenamic Acid-d4 An internal standard for the quantification of tolfenamic acid
- GC45063 Toll-Like Receptor 7 Ligand II Toll-Like Receptor 7 Ligand II (CL-087) ist ein potenter, oral aktiver TLR7-Agonist.
- GC49150 Tpl2 Kinase Inhibitor (hydrochloride) A Tpl2 inhibitor
- GC48202 Treprostinil (diethanolamine salt) Treprostinil (UT-15C) Diethanolamin ist ein potenter EP2-, DP1- und IP-Agonist mit Ki-Werten von 3,6, 4,4, 32,1, 212, 826, 2505 und 4680 nM fÜr EP2, DP1, IP, EP1, EP4, EP3 bzw. FP .
- GC49685 Trifluoroacetyl Tripeptide-2 (acetate) A peptide inhibitor of pancreatic and neutrophil elastases
- GC49884 Trigonelline-d3 (chloride) An internal standard for the quantification of trigonelline
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GC41638
TSI-01
Platelet-aktivierender Faktor (PAF) ist ein proinflammatorischer Phospholipid-Mediator, der schnell durch Lyso-PAF-Acetyltransferase (Lyso-PAFAT) als Reaktion auf extrazelluläre Stimuli synthetisiert wird.
- GC52412 TT-232 (trifluoroacetate salt) A synthetic peptide derivative of somatostatin
- GC49099 Tuftsin (human) (trifluoroacetate salt) A phagocytosis-stimulating peptide
- GC49835 Tumulosic Acid TumulosinsÄure, ein Triterpenoid, hemmt die KLK5-ProteaseaktivitÄt (IC50 = 14,84 μ M).
- GC48987 UDP (sodium salt hydrate) An agonist of P2Y6
- GC52364 Vimentin (139-159)-biotin Peptide A biotinylated vimentin peptide