(-)-FINO2
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| Catalog No.GC45248 |
(-)-FINO2 is an organic peroxide that can selectively induce ferroptosis and is used to study the mechanisms of ferroptosis and anticancer therapy.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869298-31-7
Sample solution is provided at 25 µL, 10mM.
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(-)-FINO2 is an organic peroxide that can selectively induce ferroptosis and is used to study the mechanisms of ferroptosis and anticancer therapy[1]. (-)-FINO2 can specifically induce iron-dependent lipid peroxidation by depleting glutathione and inhibiting GPX4 activity to trigger ferroptosis[2]. (-)-FINO2 can be used to investigate the role of ferroptosis in pathological processes such as tumor suppression, neurodegenerative diseases, and ischemia-reperfusion injury[3-4].
In vitro, treatment of human articular chondrocytes (C-28/I2, T/C-28/A2 cell lines, and primary chondrocytes) with (-)-FINO2 (20μM) for 24 hours significantly reduces cell viability by oxidizing unstable Fe²⁺ and indirectly inhibiting GPX4 activity to trigger ferroptosis[5]. Treatment of HT-1080 fibrosarcoma cells with (-)-FINO2 (10μM) for 24 hours significantly induces cell death via an iron-dependent lipid peroxidation pathway[6].
References:
[1] Abrams RP, Carroll WL, Woerpel KA. Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells. ACS Chem Biol. 2016 May 20;11(5):1305-12.
[2] Lei Y, Peng X, Hu Y, et al. The Calcilytic Drug Calhex-231 Ameliorates Vascular Hyporesponsiveness in Traumatic Hemorrhagic Shock by Inhibiting Oxidative Stress and miR-208a-Mediated Mitochondrial Fission. Oxid Med Cell Longev. 2020 Dec 3;2020:4132785.
[3] JHuang Y, Ru Q, Ruan H, et al. Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis. J Ethnopharmacol. 2025 Feb 27;342:119415.
[4] Van Kessel ATM, Cosa G. Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2317616121.
[5] Wipplinger A, Bekric D, Ablinger C, et al. Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. J Cell Mol Med. 2025 Jul;29(13):e70592.
[6] Gaschler MM, Andia AA, Liu H, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.
| Cell experiment [1]: | |
Cell lines | HT-1080 fibrosarcoma cells (ferroptosis-sensitive cell line) |
Preparation Method | HT-1080 cells were cultured in DMEM supplemented with 10% fetal bovine serum (FBS) at 37°C, 5% CO₂. Cells were treated with 10μM (-)-FINO2 for 6 or 24 hours. |
Reaction Conditions | 10μM; 6-24 hours |
Applications | (-)-FINO2 (10 μM) significantly induces cell death via an iron-dependent lipid peroxidation pathway. |
References: | |
| Cas No. | 869298-31-7 | SDF | |
| Canonical SMILES | CC(C)(C)[C@@H](CC1)CC[C@]21CC(CCO)(C)OO2 | ||
| Formula | C15H28O3 | M.Wt | 256.4 |
| Solubility | 30 mg/ml in DMSO, 30 mg/ml DMF, 30 mg/ml in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.9002 mL | 19.5008 mL | 39.0016 mL |
| 5 mM | 780 μL | 3.9002 mL | 7.8003 mL |
| 10 mM | 390 μL | 1.9501 mL | 3.9002 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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