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Cholecystokinin Receptor

Cholecystokinin (CCK) is a neuropeptide that affects growth rate in chickens by regulating appetite. CCK peptides exert their function by binding to two identified receptors, CCKAR and CCKBR in the GI tract and the brain, respectively, as well as in other organs. In mammals, CCK/CCKAR interactions affect a number of immunological parameters, including regulation of lymphocytes and functioning of monocytes.

CCK, also known as pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum. The main function of CCK is to cause the release of digestive enzymes and bile from the pancreas and gallbladder, respectively. It also induces drug tolerance to opioids like morphine and heroin. Cholecystokinin (CCK) has strong bioactivity in the regulation of a number of cell activities.

Targets for  Cholecystokinin Receptor

Products for  Cholecystokinin Receptor

  1. Cat.No. Product Name Information
  2. GC31558 CCK-A receptor inhibitor 1

    CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.

    CCK-A receptor inhibitor 1  Chemical Structure
  3. GC30752 CCK-B Receptor Antagonist 1 CCK-B Receptor Antagonist 1 is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid. CCK-B Receptor Antagonist 1  Chemical Structure
  4. GC38746 CCK-B Receptor Antagonist 2 CCK-B Receptor Antagonist 2, compound 15b, is a potent and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.43 nM. CCK-B Receptor Antagonist 2  Chemical Structure
  5. GC30008 Ceruletide (Caerulein) Ceruletide (Caerulein) is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide (Caerulein)  Chemical Structure
  6. GC30674 CHEMBL333994 (FK-480) CHEMBL333994 (FK-480) is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 (FK-480)  Chemical Structure
  7. GC18139 Devazepide CCK1 (CCK-A) receptor antagonist, orally active Devazepide  Chemical Structure
  8. GC35846 Dexloxiglumide Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide  Chemical Structure
  9. GC15133 Gastrin I (human) Selective CCK2 receptor agonist Gastrin I (human)  Chemical Structure
  10. GC30680 Gastrin/CCK antagonist 1 Gastrin/CCK antagonist 1 is an antagonist of gastrin/CCK, used for the research of gastrointestinal disorders. Gastrin/CCK antagonist 1  Chemical Structure
  11. GC31592 GI 181771 GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. GI 181771  Chemical Structure
  12. GC10360 Lorglumide (sodium salt) nonpeptidic antagonist of the CCK A receptor Lorglumide (sodium salt)  Chemical Structure
  13. GC31382 Loxiglumide (CR-1505) Loxiglumide (CR-1505) is a cholecystokinin (CCK-1) receptor antagonist. Loxiglumide (CR-1505)  Chemical Structure
  14. GC36610 Mini Gastrin I, human Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. Mini Gastrin I, human  Chemical Structure
  15. GC36611 Mini Gastrin I, human TFA Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. Mini Gastrin I, human TFA  Chemical Structure
  16. GC19258 Nastorazepide Nastorazepide (Z-360) is a selective, orally available, 1,5-benzodiazepine-derivative gastrin/cholecystokinin 2 (CCK-2) receptor antagonist with potential antineoplastic activity. Nastorazepide  Chemical Structure
  17. GC32776 Pentagastrin (ICI-50123) Pentagastrin (ICI-50123) (ICI-50123) is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin (ICI-50123)  Chemical Structure
  18. GC36976 Proglumide Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide  Chemical Structure
  19. GC11012 Proglumide sodium salt Proglumide sodium salt is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide sodium salt  Chemical Structure
  20. GC31407 Sograzepide (Netazepide) Sograzepide (Netazepide)(Netazepide; YF 476; YM-220) is an extremelypotent, highlyselectiveand orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Sograzepide (Netazepide)  Chemical Structure
  21. GC31613 SR 146131 SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist. SR 146131  Chemical Structure
  22. GC14258 SR 27897 SR 27897 (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. SR 27897  Chemical Structure
  23. GC31477 Tarazepide

    Tarazepide is a potent and specific CCK-A receptor antagonist.

    Tarazepide  Chemical Structure

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