Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Neuroscience >> iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Targets for  iGluR

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC16986 SDZ 220-581 hydrochloride NMDA receptor antagonist SDZ 220-581 hydrochloride Chemical Structure
  3. GC37703 Sunifiram Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam. Sunifiram Chemical Structure
  4. GC16101 SYM 2081 kainate receptor agonist SYM 2081 Chemical Structure
  5. GC13728 SYM 2206 AMPA receptor antagonist SYM 2206 Chemical Structure
  6. GC64650 TAK-653 TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. TAK-653 Chemical Structure
  7. GC19346 Talampanel Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Talampanel Chemical Structure
  8. GC30774 Tat-NR2B9c

    Tat-NR2B9c is designed to prevent nitric oxide (NO) production by preventing postsynaptic density protein 95 (PSD-95) binding to N-methyl-D-aspartate (NMDA) receptors and neuronal nitric oxide synthase.

     Tat-NR2B9c Chemical Structure
  9. GC34828 Tat-NR2B9c TFA Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA Chemical Structure
  10. GC11585 TCN 237 dihydrochloride TCN 237 dihydrochloride is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. TCN 237 dihydrochloride Chemical Structure
  11. GC33341 Transcrocetin (trans-Crocetin) Transcrocetin (trans-Crocetin) (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetin (trans-Crocetin) (trans-Crocetin) is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin (trans-Crocetin) Chemical Structure
  12. GC37821 Transcrocetin meglumine salt Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetin meglumine salt Chemical Structure
  13. GC32447 Transcrocetinate disodium (Disodium trans-crocetinate) Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetinate disodium (Disodium trans-crocetinate) Chemical Structure
  14. GC30839 Traxoprodil

    An antagonist of NR2B subunit-containing NMDA receptors

     Traxoprodil Chemical Structure
  15. GC33685 Tulrampator (CX-1632) Tulrampator (CX-1632) (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Tulrampator (CX-1632) Chemical Structure
  16. GC38446 UBP 302 An antagonist of GluR5 subunit-containing kainate receptors UBP 302 Chemical Structure
  17. GC70084 UBP301 hydrochloride

    UBP301 hydrochloride is an effective selective antagonist of kainate receptors, with IC50 and KD values of 164 μM and 5.94 μM, respectively. UBP301 hydrochloride has a selectivity for kainate receptors over AMPA receptors that is 30 times higher. It is a derivative of Willardiine.

     UBP301 hydrochloride Chemical Structure
  18. GC31153 UK-240455 UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. UK-240455 Chemical Structure
  19. GC67922 Zelquistinel Zelquistinel Chemical Structure
  20. GC16300 ZK 200775 ZK 200775 (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. ZK 200775 Chemical Structure
  21. GC30818 ZL006 ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis. ZL006 Chemical Structure
  22. GC30457 Zonampanel (YM 872) Zonampanel (YM 872) (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. Zonampanel (YM 872) Chemical Structure

Items 101 to 121 of 121 total

per page
  2. 1
  3. 2

Set Descending Direction