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Home >> Signaling Pathways >> GPCR/G protein >> LPL Receptor

LPL Receptor

LPL receptor (lysophospholipid receptor) is a group of receptors that belong to GPCRs and are important for lipid signaling.

Products for  LPL Receptor

  1. Cat.No. Product Name Information
  2. GC71271 (S)-FTY720-phosphonate FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. (S)-FTY720-phosphonate Chemical Structure
  3. GC42011 1-Oleoyl Lysophosphatidic Acid

    1-Oleoyl LPA, Oleoyl-sn-3-Glycerophosphate

    A potent LPA receptor agonist

     1-Oleoyl Lysophosphatidic Acid Chemical Structure
  4. GC39678 4-Deoxypyridoxine 5'-phosphate

    4-Deoxypyridoxine Phosphate, DOP-P, DOP Phosphate, NSC 29870

     A vitamin B6 analog and an inhibitor of S1P lyase 4-Deoxypyridoxine 5'-phosphate Chemical Structure
  5. GC15908 AM-095 free base A selective LPA1 receptor antagonist AM-095 free base Chemical Structure
  6. GC15220 AM095 A selective LPA1 receptor antagonist AM095 Chemical Structure
  7. GC13476 AM966 A potent and selective LPA1 receptor antagonist AM966 Chemical Structure
  8. GC19031 Amiselimod hydrochloride

    MT-1303

     Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride Chemical Structure
  9. GC31904 AS2717638 AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 Chemical Structure
  10. GC31870 ASP-4058 ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. ASP-4058 Chemical Structure
  11. GC62851 ASP-4058 hydrochloride ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. ASP-4058 hydrochloride Chemical Structure
  12. GC35409 ASP6432 ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively. ASP6432 Chemical Structure
  13. GC17201 BAF312 (Siponimod)

    BAF312

     BAF312 (Siponimod) (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. BAF312 (Siponimod) Chemical Structure
  14. GC19078 BMS-986020

    AM-000152

     BMS-986020 is an LPA1 antagonist. BMS-986020 Chemical Structure
  15. GC38470 BMS-986020 sodium

    AM152 sodium

     BMS-986020 (AM152) sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 sodium Chemical Structure
  16. GC63895 BMS-986278 BMS-986278 is an orally active, high-affinity and potent small molecule LPA1 antagonist that is commonly used in the study of progressive fibrotic interstitial lung disease. BMS-986278 Chemical Structure
  17. GC19100 Cenerimod

    ACT-334441

     Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. Cenerimod Chemical Structure
  18. GC18348 Ceralifimod

    ONO-4641

     Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P1 and S1P5 (Kis = 0.626 and 0.574 nM, respectively). Ceralifimod Chemical Structure
  19. GC10728 CYM 50260 S1P4 agonist CYM 50260 Chemical Structure
  20. GC15903 CYM 50308

    CID49835928, ML248

     S1P4 agonist CYM 50308 Chemical Structure
  21. GC16946 CYM 5541

    CID17253208, ML249

     sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist CYM 5541 Chemical Structure
  22. GC63345 CYM50358 CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 Chemical Structure
  23. GC19146 Etrasimod

    APD334

     Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. Etrasimod Chemical Structure
  24. GC43666 Fingolimod Fingolimod is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb I. Fingolimod Chemical Structure
  25. GC14807 Fingolimod (FTY720) HCl

    Gilenia; FTY 720; FTY-720

    Fingolimod (FTY720), an immunosuppressant agent, usually used in the treatment of multiple sclerosis, also has anticancer actions and can act as an HDACi (Histone deacetylase inhibitors)[1].

     Fingolimod (FTY720) HCl Chemical Structure
  26. GC68424 Fingolimod-d4 hydrochloride

    FTY720-d4

     Fingolimod-d4 hydrochloride Chemical Structure
  27. GC31736 FTY720 (S)-Phosphate ((S)-FTY720P)

    (S)FTY 720P

     FTY720 (S)-Phosphate ((S)-FTY720P) is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. FTY720 (S)-Phosphate ((S)-FTY720P) Chemical Structure
  28. GC62990 GLPG2938 GLPG2938 is a potent and selective S1P2 antagonist. GLPG2938 Chemical Structure
  29. GC31863 GSK2018682 An S1P1 and S1P5 receptor agonist GSK2018682 Chemical Structure
  30. GC38082 JTE-013 A selective S1P2 receptor antagonist JTE-013 Chemical Structure
  31. GC11374 Ki16425

    Debio 0719

     Ki16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 and Ki values are 0.25 and 0.36μM respectly. Ki16425 reduces the LPA-induced activation of p42/p44 MAPK.Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway. Ki16425 Chemical Structure
  32. GC31958 LPA1 antagonist 1 LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC50 of 25 nM. LPA1 antagonist 1 Chemical Structure
  33. GC12655 LPA2 antagonist 1

    LPA2-IN-1

     selective inhibitor of LPA2 activity LPA2 antagonist 1 Chemical Structure
  34. GC38923 LPA2 antagonist 2 LPA2 antagonist 2 (H2L 5226501) is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM). LPA2 antagonist 2 Chemical Structure
  35. GC73099 LX2931 LX2931 is an inhibitor of Sphingosine 1-Phosphate Lyase (S1PL). LX2931 Chemical Structure
  36. GC62327 Mocravimod hydrochloride Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist. Mocravimod hydrochloride Chemical Structure
  37. GC65579 ONO-0300302 ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 Chemical Structure
  38. GC69624 ONO-0740556

    ONO-0740556 is an effective Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with an EC50 value of 0.26 nM.

     ONO-0740556 Chemical Structure
  39. GC12362 ONO-7300243 LPA1 antagonist ONO-7300243 Chemical Structure
  40. GC63128 ONO-9780307 ONO-9780307 is a specific synthetic LPA1 (lysophosphatidic acid receptor 1) antagonist with an IC50 value of 2.7 nM. ONO-9780307 Chemical Structure
  41. GC14360 Ozanimod (RPC1063) Ozanimod (RPC1063) (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod (RPC1063) Chemical Structure
  42. GC69645 Ozanimod hydrochloride

    RPC-1063 hydrochloride

    Ozanimod (RPC-1063) hydrochloride is a sphingosine 1-phosphate (S1P) receptor modulator that selectively and with high affinity binds to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has regulatory effects on hS1P1 and hS1P5 receptors, with EC50 values of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for research on relapsing multiple sclerosis (MS).

     Ozanimod hydrochloride Chemical Structure
  43. GC50253 PF 543 hydrochloride

    Sphingosine Kinase 1 Inhibitor II hydrochloride

     Potent and selective SphK1 inhibitor PF 543 hydrochloride Chemical Structure
  44. GC36884 PF429242 dihydrochloride A site-1 protease inhibitor PF429242 dihydrochloride Chemical Structure
  45. GC16660 Ponesimod

    ACT-128800

     sphingosine-1-phosphate receptor 1 (S1P1) modulator Ponesimod Chemical Structure
  46. GC34752 Radioprotectin-1 Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype. Radioprotectin-1 Chemical Structure
  47. GC65324 RP101988 RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely. RP101988 Chemical Structure
  48. GC19316 S1p receptor agonist 1

    S1p receptor agonist 1

     S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2. S1p receptor agonist 1 Chemical Structure
  49. GC32006 S1PR1-MO-1 S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases. S1PR1-MO-1 Chemical Structure
  50. GC31785 SAR-100842

    SAR-100842 is a potent, selective oral antagonist of the LPAR1, for diffuse cutaneous systemic sclerosis .

     SAR-100842 Chemical Structure
  51. GC65910 SAR247799

    S1P1 agonist 3

     SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome. SAR247799 Chemical Structure
  52. GC18116 SEW 2871 sphingosine-1-phosphate 1 (S1P1) receptor agonist SEW 2871 Chemical Structure
  53. GC73297 SLB1122168 formic SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM. SLB1122168 formic Chemical Structure
  54. GC66459 SLF1081851 SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system. SLF1081851 Chemical Structure
  55. GC69926 Sonepcizumab

    LT 1009; Anti-Human S1P Recombinant Antibody

    Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. It has potential for use in the research of metastatic renal cell carcinoma (mRCC).

     Sonepcizumab Chemical Structure
  56. GC14532 TC-G 1006 S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. TC-G 1006 Chemical Structure
  57. GC13720 TY 52156 sphingosine-1-phosphate receptor 3 (SIP3) antagonist TY 52156 Chemical Structure
  58. GC64434 Vibozilimod

    SCD-044

     Vibozilimod (SCD-044, example 33) is a S1p1 receptor agonist (extracted from patent WO2012140020A1). Vibozilimod Chemical Structure
  59. GC15694 VPC 23019

    S1P1/S1P3 receptor antagonist

     VPC 23019 Chemical Structure
  60. GC16621 W146

    sphingosine-1-phosphate receptor S1P1 antagonist

     W146 Chemical Structure
  61. GC63414 Zectivimod Zectivimod Chemical Structure

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