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Home >> Signaling Pathways >> Tyrosine Kinase >> c-FMS

c-FMS

c-Fms (colony-stimulating factor-1 receptor) is a sole receptor for M-CSF, and is a receptor tyrosine kinase.

Products for  c-FMS

  1. Cat.No. Product Name Information
  2. GC74505 Anumigilimab

    CSL-324

     Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab Chemical Structure
  3. GC72392 Axatilimab Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab Chemical Structure
  4. GC19404 AZD7507

    AZD7507 is a potent and selective CSF-1R inhibitor (32 nM cell activity)

     AZD7507 Chemical Structure
  5. GC12539 BLZ945

    BLZ945

     BLZ945 (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. BLZ945 Chemical Structure
  6. GC34529 c-Fms-IN-1 c-Fms-IN-1 is a FMS kinase inhibitor with an IC50 of 0.0008 μM. c-Fms-IN-1 Chemical Structure
  7. GC35663 c-Fms-IN-10 c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC50 of 2 nM. c-Fms-IN-10 Chemical Structure
  8. GC66028 c-Fms-IN-13 c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor with an IC50 value of 17 nM. c-Fms-IN-13 can be used as an anti-inflammatory agent. c-Fms-IN-13 Chemical Structure
  9. GC35664 c-Fms-IN-3 c-Fms-IN-3 is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent. c-Fms-IN-3 Chemical Structure
  10. GC35665 c-Fms-IN-8 c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. c-Fms-IN-8 Chemical Structure
  11. GC35666 c-Fms-IN-9 c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively. c-Fms-IN-9 Chemical Structure
  12. GC68820 Cabiralizumab

    FPA 008; Anti-Human CSF1R Recombinant Antibody

    Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab can enhance T cell infiltration and anti-tumor T cell immune response. Cabiralizumab inhibits osteoclast activation and prevents bone destruction, which can be used for research on rheumatoid arthritis (RA). Cabiralizumab can be combined with Nivolumab for lung cancer research.

     Cabiralizumab Chemical Structure
  13. GC34528 cFMS Receptor Inhibitor II cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. cFMS Receptor Inhibitor II Chemical Structure
  14. GC65976 cFMS Receptor Inhibitor IV cFMS Receptor Inhibitor IV (Compound 42) is a potent cFMS inhibitor with an IC50 of 0.017 μM. cFMS Receptor Inhibitor IV Chemical Structure
  15. GC31726 cFMS-IN-2 cFMS-IN-2 is a FMS kinase inhibitor with an IC50 of 0.024 μM. cFMS-IN-2 Chemical Structure
  16. GC62145 Chiauranib

    CS2164

     Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects. Chiauranib Chemical Structure
  17. GC33241 CSF1R-IN-1 CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM. CSF1R-IN-1 Chemical Structure
  18. GC64961 CSF1R-IN-2

    CSF1R-IN-2, CSF1R Inhibitor 2, Elzovantinib

     CSF1R-IN-2 (compound 5) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively. CSF1R-IN-2 Chemical Structure
  19. GC73906 CSF1R-IN-24 CSF1R-IN-24 (Example 134) is an orally active CSF1R inhibitor. CSF1R-IN-24 Chemical Structure
  20. GC64805 CSF1R-IN-3 CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity. CSF1R-IN-3 Chemical Structure
  21. GC19418 Edicotinib

    JNJ-40346527; JNJ-527

     Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. Edicotinib Chemical Structure
  22. GC31842 GENZ-882706 (RA03546849)

    RA03546849

     GENZ-882706 (RA03546849) is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. GENZ-882706 (RA03546849) Chemical Structure
  23. GC30295 GENZ-882706(Raceme) (GENZ-882706 racemate)

    GENZ-882706 racemate

     GENZ-882706(Raceme) (GENZ-882706 racemate) is the racemate of GENZ-882706. GENZ-882706(Raceme) (GENZ-882706 racemate) Chemical Structure
  24. GC17286 GW2580 CFMS kinase/CSF-1R inhibitor,selective and ATP-competitive GW2580 Chemical Structure
  25. GC72816 GW2580-d6 GW2580-d6 is the deuterium labeled GW2580. GW2580-d6 Chemical Structure
  26. GC69321 JTE-952

    JTE-952 is an orally active, type II selective inhibitor of colony-stimulating factor-1 receptor (CSF-1R/cFMS) that effectively inhibits CSF1R and TrkA with IC50 values of 13 nM and 261 nM, respectively. It can be used for research related to arthritis.

     JTE-952 Chemical Structure
  27. GC13264 Ki20227

    Ki 20227;Ki-20227

     A c-Fms kinase inhibitor Ki20227 Chemical Structure
  28. GC17958 Linifanib (ABT-869)

    Linifanib

     Linifanib (ABT-869) (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (ABT-869) shows prominent antitumor activity. Linifanib (ABT-869) has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib (ABT-869) is a specific miR-10b inhibitor that blocks miR-10b biogenesis. Linifanib (ABT-869) Chemical Structure
  29. GC66349 Mavrilimumab

    CAM 3001

     Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death. Mavrilimumab Chemical Structure
  30. GC14957 OSI-930 Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck OSI-930 Chemical Structure
  31. GC72439 Otilimab Otilimab (GSK 3196165) is an anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) human monoclonal antibody. Otilimab Chemical Structure
  32. GC12730 Pazopanib Hydrochloride

    GW786034;Votrient;Armala;GW 786034;GW-786034

     VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor Pazopanib Hydrochloride Chemical Structure
  33. GC72911 Pazopanib-13C,d3 hydrochloride

    GW786034-13C,d3 hydrochloride

     Pazopanib-13C,d3 (drochloride) is the deuterium and 13C labeled Pazopanib drochloride. Pazopanib-13C,d3 hydrochloride Chemical Structure
  34. GC12222 Pexidartinib (PLX3397)

    PLX3397

    Pexidartinib(PLX3397) is an orally administered small molecule tyrosine kinase inhibitor with potent selective activity against the colony-stimulating factor 1(CSF1) receptor(IC50=20nM), KIT proto-oncogene receptor tyrosine kinase(KIT)(IC50 =10nM) and FMS-like tyrosine kinase.

     Pexidartinib (PLX3397) Chemical Structure
  35. GC34708 Pexidartinib hydrochloride Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity. Pexidartinib hydrochloride Chemical Structure
  36. GC73511 Pimicotinib

    ABSK021

     Pimicotinib is a CSF1R inhibitor with antitumor activity. Pimicotinib Chemical Structure
  37. GC36940 PLX5622 A CSF1R inhibitor PLX5622 Chemical Structure
  38. GC38836 PLX5622 hemifumarate PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 hemifumarate Chemical Structure
  39. GC15075 PLX647 dual inhibitor of FMS and KIT kinases PLX647 Chemical Structure
  40. GC32802 PRN1371 An irreversible pan-FGFR inhibitor PRN1371 Chemical Structure
  41. GC69931 Sotuletinib hydrochloride

    BLZ945 hydrochloride

    Sotuletinib (BLZ945) is an effective, selective, and brain-penetrant inhibitor of CSF-1R (c-Fms), with an IC50 of 1 nM and a selectivity that is 1000 times greater than other receptor tyrosine kinases.

     Sotuletinib hydrochloride Chemical Structure
  42. GC73924 SYHA1813 SYHA1813 is a dual inhibitor of CSF1R and VEGFR. SYHA1813 Chemical Structure

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