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Home >> Signaling Pathways >> Tyrosine Kinase >> HER2

HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

Products for  HER2

  1. Cat.No. Product Name Information
  2. GC13257 AC480 (BMS-599626) AC480 (BMS-599626) (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. AC480 (BMS-599626) displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. AC480 (BMS-599626) inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy. AC480 (BMS-599626) Chemical Structure
  3. GC10707 Afatinib dimaleate An inhibitor of EGFR and ErbB2 Afatinib dimaleate Chemical Structure
  4. GC10606 BMS-599626 Hydrochloride BMS-599626 Hydrochloride Chemical Structure
  5. GC12087 Canertinib dihydrochloride A pan-ErbB tyrosine kinase inhibitor Canertinib dihydrochloride Chemical Structure
  6. GC13091 CP-724714 HER2 inhibitor,potent and selective CP-724714 Chemical Structure
  7. GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2 CUDC-101 Chemical Structure
  8. GC10250 Mubritinib (TAK 165) Mubritinib (TAK 165) (TAK-165) is a potent and selective EGFR2/HER2 inhibitor with an IC50 of 6 nM. Mubritinib (TAK 165) Chemical Structure
  9. GC10362 Neratinib (HKI-272) Neratinib (HKI-272) (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. Neratinib (HKI-272) Chemical Structure
  10. GC17473 Pelitinib (EKB-569) Pelitinib (EKB-569) (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. Pelitinib (EKB-569) Chemical Structure
  11. GC17916 Poziotinib A irreversible pan-HER inhibitor Poziotinib Chemical Structure
  12. GC11172 TAK-285 HER2/EGFR(HER1) inhibitor TAK-285 Chemical Structure
  13. GC15271 Tyrphostin AG 879 HER2 inhibitor Tyrphostin AG 879 Chemical Structure

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