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Home >> Signaling Pathways >> Tyrosine Kinase >> IGF1R

IGF1R

IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.

Products for  IGF1R

  1. Cat.No. Product Name Information
  2. GC13697 AG-1024

    AGS 200, Tyrphostin AG1024

     AG-1024 is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 value of 7µM. AG-1024 can inhibit the phosphorylation of insulin receptor (IR) with an IC50 value of 57µM. AG-1024 Chemical Structure
  3. GC17045 AXL1717

    AXL 1717, NSC 36407, Picropodophyllin, PPP

     A potent and selective inhibitor of IGF-1R AXL1717 Chemical Structure
  4. GC33072 AZ7550 AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. AZ7550 Chemical Structure
  5. GC34287 AZ7550 hydrochloride AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. AZ7550 hydrochloride Chemical Structure
  6. GC34414 AZ7550 Mesylate (AZ7550 trimesylate salt) AZ7550 Mesylate (AZ7550 trimesylate salt) Chemical Structure
  7. GC14189 AZD-3463

    ALK/IGF1R inhibitor

     ALK/IGF1R inhibitor AZD-3463 Chemical Structure
  8. GC17773 BMS-536924

    IR/IGF-1R inhibitor

     BMS-536924 Chemical Structure
  9. GC16712 BMS-754807 IGF-1R/InsR inhibitor,potent and selective BMS-754807 Chemical Structure
  10. GC45789 Ceritinib-d7

    LDK 378-d7

     An internal standard for the quantification of ceritinib Ceritinib-d7 Chemical Structure
  11. GC91419 CYY292 CYY292 is an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, (IC50s = 5.35, 4.6, 28, 28, and 78 nM, respectively). CYY292 Chemical Structure
  12. GC72454 Dusigitumab Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody that specifically targets IGF2 and IGF1. Dusigitumab Chemical Structure
  13. GC69112 Figitumumab

    CP-751871

    Figitumumab (CP-751871) is an effective fully human monoclonal antibody against insulin-like growth factor 1 receptor (IGF1R). Figitumumab can block the binding of IGF1 to IGF1R, with an IC50 of 1.8 nM.

     Figitumumab Chemical Structure
  14. GC69149 Ganitumab

    AMG 479; Human Anti-IGF1R Recombinant Antibody

    Ganitumab (AMG 479) is a recombinant human monoclonal antibody that targets type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes mouse IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction between mouse IGF1R and IGF1/IGF2. Ganitumab can be used for cancer research.

     Ganitumab Chemical Structure
  15. GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities Ginsenoside Rg5 Chemical Structure
  16. GC12273 GSK1838705A IGF-IR/IR/ALK inhibitor, ATP-competitive GSK1838705A Chemical Structure
  17. GC17612 GSK1904529A

    GSK4529

     Selective IGF-1R/IR inhibitor GSK1904529A Chemical Structure
  18. GC63297 I-OMe-Tyrphostin AG 538

    I-OMe-AG 538

     I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 Chemical Structure
  19. GC36311 Indirubin Derivative E804 Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. Indirubin Derivative E804 Chemical Structure
  20. GC14552 LDK378

    LDK 378;LDK-378;Ceritinib

     LDK378 (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. LDK378 Chemical Structure
  21. GC17452 LDK378 dihydrochloride LDK378 dihydrochloride Chemical Structure
  22. GC15749 Linsitinib

    OSI 906; OSI-906; OSI906

     IGF1R/IR inhibitor,potent and novel Linsitinib Chemical Structure
  23. GC61111 NBI-31772 hydrate NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate Chemical Structure
  24. GC12712 NT157 IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway NT157 Chemical Structure
  25. GC14310 NVP-ADW742

    ADW742, GSK552602A

     Selective IGF-1R inhibitor NVP-ADW742 Chemical Structure
  26. GC12963 NVP-AEW541

    AEW541

     IGF-IR inhibitor, novel, potent and selective NVP-AEW541 Chemical Structure
  27. GC44474 NVP-AEW541 (hydrochloride) Insulin-like growth factor 1 receptor (IGF-1R) is a receptor tyrosine kinase whose activation leads to angiogenesis as well as cell proliferation, survival, transformation, and metastasis. NVP-AEW541 (hydrochloride) Chemical Structure
  28. GC16991 PQ 401 IGF1R inhibitor,potent and cell-permeable PQ 401 Chemical Structure
  29. GC69825 Robatumumab

    Sch 717454; 19D12

    Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor 1 receptor) antibody. Robatumumab has anti-tumor activity and anti-cancer cell proliferation activity. Robatumumab can be used for research on osteosarcoma and Ewing's sarcoma.

     Robatumumab Chemical Structure
  30. GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells. S961 Chemical Structure
  31. GC16821 TAE226(NVP-TAE226)

    TAE 226;TAE-226

     TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226) Chemical Structure
  32. GC70013 Teprotumumab

    Teprotumumab is a human monoclonal antibody that blocks the insulin-like growth factor-1 receptor (IGF-1R). Teprotumumab binds to the ligand-binding domain of the extracellular alpha subunit of IGF-1R. It inhibits the actions of TSH and IGF-1 in fibroblasts. Teprotumumab reduces the expression of IL-6 and IL-8, which are dependent on TSH, as well as phosphorylation of Akt. It can be used for research related to thyroid-associated eye disease.

     Teprotumumab Chemical Structure
  33. GC74445 Veligrotug Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody. Veligrotug Chemical Structure
  34. GC70151 Xentuzumab

    BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody

    Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant humanized monoclonal antibody that targets the IGF ligands IGF1 and IGF2. Xentuzumab inhibits the growth-promoting signals of both IGF1 and IGF2, suppressing the activation of AKT.

     Xentuzumab Chemical Structure
  35. GC13102 XL228 A tyrosine kinase inhibitor XL228 Chemical Structure

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