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Tubercidin

Catalog No.GC16879

Tubercidin Chemical Structure

adenosine analog antibiotic agent

Size Price Stock Qty
10 mM * 1 mL in DMSO
$68.00
In stock
5mg
$49.00
In stock
25mg
$152.00
In stock
100mg
$332.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Background

IC50: 3.4 and 3.7 nM for granulocyte-macrophage CFU (CFU-GM) and erythroid burst-forming units (BFU-E), respectively

Tubercidin is an adenosine analog antibiotic agent.

Nucleoside antibiotics are a family of natural products with various biological functions. Their biosynthesis is a complex process via multistep enzymatic reactions.

In vitro: Previous study showed that tubercidin alone had a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells. BFU-E were more sensitive at higher doses of tubercidin than CFU-GM. The 99% complete inhibition of BFU-E colonies was observed at 10 nM tubercidin, whereas complete inhibition of CFU-GM occurred at 100 nM [1].

In vivo: Animal toxicity study showed that four successive daily injections of tubercidin at 5 mg/kg per day could produce 100% mouse mortality within 3 to 5 days, with massive peritonitis and intestinal obstruction. In addition, coadministration of NBMPR-P at 25 mg/kg per day could protect the mice from the tubercidin lethality and allow the repetition of the regimen for a second time with 100% survival [1].

Clinical trial: Previous clinical study has been conduct to evaluate tubercidin administered after absorption into human erythrocytes, and the results showed that toxicity to the drug was uncommon and usually not severe. Moreover, the biological effect was obvious between 4 and 12 weeks after the onset of therapy [2].

References:
[1] el Kouni MH,Diop D,O'Shea P,Carlisle R,Sommadossi JP.  Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob Agents Chemother.1989 Jun;33(6):824-7.
[2] Grage TB,Rochlin DB,Weiss AJ,Wilson WL.  Clinical studies with tubercidin administered after absorption into human erythrocytes. Cancer Res.1970 Jan;30(1):79-81.

Chemical Properties

Cas No. 69-33-0 SDF
Synonyms N/A
Chemical Name (2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Canonical SMILES NC1=NC=NC2=C1C=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3
Formula C11H14N4O4 M.Wt 266.25
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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