Z-AEVD-FMK (Synonyms: Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) |
| Catalog No.GC45177 |
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1135688-47-9
Sample solution is provided at 25 µL, 10mM.
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Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]
Reference:
[1]. Park, S.J., Wu, C.H., Gordon, J.D., et al. Taxol induces caspase-10-dependent apoptosis. The Journal of Biological Chemisty 279(49), 51057-51067 (2004).
[2]. Milhas, D., Cuvillier, O., Therville, N., et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. The Journal of Biological Chemisty 280(20), 19836-19842 (2005).
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