Bis-PEG6-acid |
| Catalog No.GC60088 |
Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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Cas No.: 119189-70-7
Sample solution is provided at 25 µL, 10mM.
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Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Zorba A, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7285-E7292.
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