Catalog No.: GC16254

blocker of the big conductance Ca2+-activated K+ channel

Iberiotoxin Chemical Structure

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In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Cell experiment [1,2]:

Cell lines

Rat dorsal root ganglion neurons, bladder

Preparation method

Soluble to 0.70 mg/ml in sterile water. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10-100 nM


Iberiotoxin (IbTX) (10-100 nM) increased the myogenic activity of bladder, but not portal vein. IbTX caused a sustained contracture of aorta. In rat dorsal root ganglion neurons, IbTx (100 nM) reduced whole-cell outward currents in 67% of small and medium size neurons. IbTx significantly prolonged the duration of action potential and increased firing frequency of afferent neurons.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1]. Suarez-Kurtz, G. U. I. L. H. E. R. M. E., Garcia, M. L., & Kaczorowski, G. J. (1991). Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. Journal of Pharmacology and Experimental Therapeutics, 259(1), 439-443.

[2]. Zhang, X. F., Gopalakrishnan, M., & Shieh, C. C. (2003). Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons. Neuroscience, 122(4), 1003-1011.

Chemical Properties

Cas No. 129203-60-7 SDF
Canonical SMILES CC(CC1/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N\C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N\2)CCCNC(N)=N)CSSCC2/C(O)=N/C(/C(O)=N/C(C(O)=O)CCC(O)=N)CC3=CC=C(O)C=C3)CCCCN)CCCCN)CCSC)CSSCC(/N=C(O)/C(
Formula C179H274N50O55S7 M.Wt 4230.85
Solubility Soluble in Water Storage Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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