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Meclofenoxate hydrochloride

Catalog No.GC10443

Meclofenoxate hydrochloride Chemical Structure

Drug for senile dementia and AD treatment

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Sample solution is provided at 25 µL, 10mM.

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Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.IC50 value: Target: nootropicMeclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training [1]. Meclofenoxate appears to increase the consolidation of new information into long-term memory, but does not affect other aspects of remembering [2].

[1]. Mosharrof AH, et al. Effects of meclofenoxate and citicholine on learning and memory in aged rats. Acta Physiol Pharmacol Bulg. 1987;13(4):17-24.
[2]. Marcer D, et al. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31.

Chemical Properties

Cas No. 3685-84-5 SDF
Chemical Name 2-(dimethylamino)ethyl 2-(4-chlorophenoxy)acetate;hydrochloride
Canonical SMILES CN(C)CCOC(=O)COC1=CC=C(C=C1)Cl.Cl
Formula C12H17Cl2NO3 M.Wt 294.17
Solubility DMF: 20 mg/ml,DMSO: 33 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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