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Home >> Signaling Pathways >> GPCR/G protein >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC30412 Dolasetron (MDL-73147) Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Dolasetron (MDL-73147) Chemical Structure
  3. GC30413 Dolasetron Mesylate (MDL-73147EF) Dolasetron Mesylate (MDL-73147EF) (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Dolasetron Mesylate (MDL-73147EF) Chemical Structure
  4. GC30198 Dolasetron Mesylate hydrate Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Dolasetron Mesylate hydrate Chemical Structure
  5. GC35894 Donitriptan Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. Donitriptan Chemical Structure
  6. GC13265 Donitriptan hydrochloride 5-HT1B/1D receptors agonist, potent and selective Donitriptan hydrochloride Chemical Structure
  7. GC10679 DR 4485 hydrochloride DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14). DR 4485 hydrochloride Chemical Structure
  8. GC65014 DSP-1053 DSP-1053, a benzylpiperidine derivative, is a potent?Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 Chemical Structure
  9. GC13871 Duloxetine HCl Duloxetine HCl ((S)-Duloxetine HCl) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Duloxetine HCl Chemical Structure
  10. GC11516 DV 7028 hydrochloride 5-HT2A receptor antagonist DV 7028 hydrochloride Chemical Structure
  11. GC17053 Eletriptan HBr Eletriptan HBr (Eletriptan HBr) is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively. Eletriptan HBr Chemical Structure
  12. GC30982 Eltoprazine (DU 28853) Eltoprazine (DU 28853)(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. Eltoprazine (DU 28853) Chemical Structure
  13. GC18244 Eltoprazine (hydrochloride) Eltoprazine is a phenylpiperazine compound that acts as a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Kis = 40, 52, and 81 nM, respectively). Eltoprazine (hydrochloride) Chemical Structure
  14. GC10495 EMD 281014 hydrochloride 5-HT2A antagonist EMD 281014 hydrochloride Chemical Structure
  15. GC16045 EMD 386088 hydrochloride EMD 386088 hydrochloride is a potent serotonin 6 receptor (5-HT6R) agonist. EMD 386088 hydrochloride Chemical Structure
  16. GC15367 EMDT oxalate

    5-HT6 agonist

     EMDT oxalate Chemical Structure
  17. GC31218 Eplivanserin (SR-46349) Eplivanserin (SR-46349) (SR-46349) is a potent, selective and orally active 5-HT2A receptor antagonist, with an IC50 of 5.8 nM in rat cortical membrane, and a Kd of 1.14 nM. Eplivanserin (SR-46349) Chemical Structure
  18. GC34575 Eplivanserin mixture Eplivanserin mixture (SR-46349 mixture) is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. Eplivanserin mixture Chemical Structure
  19. GC30939 Eptapirone (F 11440) Eptapirone (F 11440) (F11440) is a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. Eptapirone (F 11440) Chemical Structure
  20. GC30910 Eucalyptol (1,8-Cineole) A bicyclic monoterpene with diverse biological activities Eucalyptol (1,8-Cineole) Chemical Structure
  21. GC31032 F-15599 F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM. F-15599 Chemical Structure
  22. GC13109 Fananserin 5-HT2A receptor antagonist Fananserin Chemical Structure
  23. GC14512 Fenspiride HCl α adrenergic and H1 histamine receptor antagonist Fenspiride HCl Chemical Structure
  24. GC32439 Ferulic acid sodium (Sodium ferulate) Ferulic acid sodium (Sodium ferulate) is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. Ferulic acid sodium (Sodium ferulate) Chemical Structure
  25. GC31011 FK1052 hydrochloride FK1052 hydrochloride ((±)-FK1052) is the racemate of Fabesetron hydrochloride, which is a potent 5-HT3 and 5-HT4 receptor dual antagonist. FK1052 hydrochloride Chemical Structure
  26. GC11100 Flibanserin full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A. Flibanserin Chemical Structure
  27. GC68364 Flibanserin-d4-1 Flibanserin-d4-1 Chemical Structure
  28. GC12535 Flopropione 5-HT receptor antagonist Flopropione Chemical Structure
  29. GC38912 Flumexadol Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol Chemical Structure
  30. GC11709 Fluoxetine HCl Serotonin reuptake inhibitor,selective Fluoxetine HCl Chemical Structure
  31. GC13092 Fluvoxamine Selective serotonin reuptake inhibitor Fluvoxamine Chemical Structure
  32. GC15025 Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant Fluvoxamine maleate Chemical Structure
  33. GC25434 Frovatriptan Succinate Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors. Frovatriptan Succinate Chemical Structure
  34. GC38781 Frovatriptan succinate hydrate An agonist of 5-HT1B and 5-HT1D receptors Frovatriptan succinate hydrate Chemical Structure
  35. GC38227 Gamma-Mangostin A xanthone with diverse biological activities Gamma-Mangostin Chemical Structure
  36. GC38529 Geissoschizine methyl ether Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether Chemical Structure
  37. GC11624 GR 113808 5-HT4 receptor antagonist GR 113808 Chemical Structure
  38. GC15248 GR 125487 sulfamate 5-HT4 receptor antagonist GR 125487 sulfamate Chemical Structure
  39. GC17140 GR 127935 hydrochloride 5-HT1B/1D receptor antagonist GR 127935 hydrochloride Chemical Structure
  40. GC14373 GR 46611 GR 46611 is a 5-HT1D receptor agonist. GR 46611 can be used in the research of bladder hyperactivity, leukemia. GR 46611 Chemical Structure
  41. GC17524 GR 55562 dihydrochloride 5-HT1B (5-HT1Dβ) silent antagonist GR 55562 dihydrochloride Chemical Structure
  42. GC16029 Granisetron HCl Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Granisetron HCl Chemical Structure
  43. GC19176 GSK163090 GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively. GSK163090 Chemical Structure
  44. GC30762 Harmine (Telepathine) A unique regulator of PPARγ expression Harmine (Telepathine) Chemical Structure
  45. GC38413 Harmine hydrochloride Harmine hydrochloride Chemical Structure
  46. GC36291 Idalopirdine A 5-HT6 receptor antagonist Idalopirdine Chemical Structure
  47. GC15463 Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist Iloperidone Chemical Structure
  48. GC10799 Iloperidone hydrochloride D(2)/5-HT(2) receptor antagonistis Iloperidone hydrochloride Chemical Structure
  49. GC31014 Irindalone (Lu 21-098) Irindalone (Lu 21-098) is a novel serotonin 5-HT2 antagonist. Irindalone (Lu 21-098) Chemical Structure
  50. GC31251 JNJ-18038683 JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. JNJ-18038683 Chemical Structure
  51. GC14563 Ketanserin

    specific 5-HT2A serotonin receptor antagonist

     Ketanserin Chemical Structure
  52. GC43999 Ketanserin (tartrate) Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). Ketanserin (tartrate) Chemical Structure
  53. GC11308 L-703,664 succinate 5-HT1D receptor agonist L-703,664 succinate Chemical Structure
  54. GC15121 Lasmiditan 5-HT1F receptor agonist Lasmiditan Chemical Structure
  55. GC36428 Lasmiditan hydrochloride Lasmiditan hydrochloride Chemical Structure
  56. GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity. Lasmiditan succinate Chemical Structure
  57. GC17974 Latrepirdine dihydrochloride Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine dihydrochloride Chemical Structure
  58. GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM. Lerisetron Chemical Structure
  59. GC33721 Lesopitron dihydrochloride (E4424) Lesopitron dihydrochloride (E4424) is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. Lesopitron dihydrochloride (E4424) Chemical Structure
  60. GC30972 Lidanserin (ZK-33839) Lidanserin (ZK-33839) (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist. Lidanserin (ZK-33839) Chemical Structure
  61. GC30352 Lintopride

    Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.

     Lintopride Chemical Structure
  62. GC13081 Loxapine 5-HT receptor antagonist Loxapine Chemical Structure
  63. GC10242 Loxapine Succinate

    Dopamine receptor antagonist

     Loxapine Succinate Chemical Structure
  64. GC14195 LP 12 hydrochloride 5-HT7 receptor agonist LP 12 hydrochloride Chemical Structure
  65. GC17044 LP 20 hydrochloride ligand of the 5-HT7 receptor LP 20 hydrochloride Chemical Structure
  66. GC18112 LP 44 LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP 44 Chemical Structure
  67. GC30880 LP-211 An agonist of 5-HT7 receptors LP-211 Chemical Structure
  68. GC30797 lumateperone Tosylate (ITI-007) Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. lumateperone Tosylate (ITI-007) Chemical Structure
  69. GC30926 Lurasidone (SM-13496) Lurasidone (SM-13496) (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) Chemical Structure
  70. GC17593 Lurasidone HCl Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone HCl Chemical Structure
  71. GC13607 LY 215840 5-HT2/5-HT7 receptor antagonist LY 215840 Chemical Structure
  72. GC10674 LY 266097 hydrochloride 5-HT2B receptor antagonist LY 266097 hydrochloride Chemical Structure
  73. GC10919 LY 272015 hydrochloride

    5-HT2B receptor antagonist

     LY 272015 hydrochloride Chemical Structure
  74. GC12657 LY 334370 hydrochloride 5-HT1F receptor agonist LY 334370 hydrochloride Chemical Structure
  75. GC36501 LY 344864 hydrochloride LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 hydrochloride Chemical Structure
  76. GC36502 LY 344864 racemate LY 344864 racemate is a 5-HT1F receptor agonist extracted from patent US 5708187 A. LY 344864 racemate Chemical Structure
  77. GC36503 LY 344864 S-enantiomer LY 344864 S-enantiomer is the S-enantiomer of LY344864. LY 344864 S-enantiomer Chemical Structure
  78. GC14738 LY 393558 Dual 5-HT1B/1D receptor antagonist LY 393558 Chemical Structure
  79. GC17138 LY310762 5-HT1D receptor antagonist LY310762 Chemical Structure
  80. GC36511 LY334370 LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM. LY334370 Chemical Structure
  81. GC15456 m-Chlorophenylbiguanide hydrochloride 5-HT3 receptor agonist m-Chlorophenylbiguanide hydrochloride Chemical Structure
  82. GC36548 Masupirdine free base Masupirdine free base (SUVN-502 free base) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base Chemical Structure
  83. GC38509 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate Chemical Structure
  84. GC10051 MDL 100907 MDL 100907 is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. MDL 100907 Chemical Structure
  85. GC11119 MDL 11,939 MDL 11,939 (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively). MDL 11,939 Chemical Structure
  86. GC14083 MDL 72222 MDL 72222 (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. MDL 72222 Chemical Structure
  87. GC11929 Melperone hydrochloride 5-HT2A/D2 receptor antagonist Melperone hydrochloride Chemical Structure
  88. GC14516 Mesulergine hydrochloride 5-HT2A and 2C receptor antagonist Mesulergine hydrochloride Chemical Structure
  89. GC10357 Metergoline 5-HT1/5-HT2 antagonist Metergoline Chemical Structure
  90. GC17360 Methiothepin maleate

    5-HT antagonist

     Methiothepin maleate Chemical Structure
  91. GC33674 Methiothepin mesylate (Metitepine mesylate) Methiothepin mesylate (Metitepine mesylate) is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). Methiothepin mesylate (Metitepine mesylate) Chemical Structure
  92. GC14724 Methylergometrine maleate 5-HT1/5-HT2 receptor antagonist Methylergometrine maleate Chemical Structure
  93. GC16470 Methysergide maleate Mixed 5-HT1/5-HT2 receptor antagonist Methysergide maleate Chemical Structure
  94. GC30446 MHP 133 MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP 133 Chemical Structure
  95. GC11447 Mirtazapine 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist Mirtazapine Chemical Structure
  96. GC17745 MK 212 hydrochloride MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK 212 hydrochloride Chemical Structure
  97. GC11787 ML 10302 hydrochloride 5-HT4 partial agonist ML 10302 hydrochloride Chemical Structure
  98. GC13428 Mosapride Selective 5HT4 agonist Mosapride Chemical Structure
  99. GC17536 Mosapride Citrate 5-HT receptor agonist Mosapride Citrate Chemical Structure
  100. GC13977 MS 245 oxalate 5-HT6 antagonist MS 245 oxalate Chemical Structure
  101. GC44259 Myristicin Myristicin is an alkenylbenzene present in small amounts in the essential oil of nutmeg that is reported to act as a serotonin receptor antagonist, a weak monamine oxidase inhibitor, and to produce hallucinogenic effects. Myristicin Chemical Structure

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