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Home >> Signaling Pathways >> GPCR/G protein >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC16553 N-Desmethylclozapine 5-HT2C serotonin receptor antagonist N-Desmethylclozapine Chemical Structure
  3. GC16399 N-Methylquipazine dimaleate 5-HT3 agonist N-Methylquipazine dimaleate Chemical Structure
  4. GC32511 Naftidrofuryl oxalate (Nafronyl oxalate salt) Naftidrofuryl oxalate (Nafronyl oxalate salt) Chemical Structure
  5. GC31057 Naluzotan (PRX 00023) Naluzotan (PRX 00023) is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM. Naluzotan (PRX 00023) Chemical Structure
  6. GC15235 NAN-190 hydrobromide

    5-HT1A antagonist

     NAN-190 hydrobromide Chemical Structure
  7. GC11959 Naratriptan Naratriptan is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches. Naratriptan Chemical Structure
  8. GC36693 Naratriptan D3 Hydrochloride Naratriptan D3 Hydrochloride is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist. Naratriptan D3 Hydrochloride Chemical Structure
  9. GC13298 NAS-181 NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS-181 Chemical Structure
  10. GC13135 NBOH-2C-CN hydrochloride 5-HT2A agonist NBOH-2C-CN hydrochloride Chemical Structure
  11. GC69545 Nefazodone

    Nefazodone is an orally active phenylpiperazine antidepressant. It effectively and selectively blocks postsynaptic 5-HT2A receptors, moderately inhibits the reuptake of serotonin and noradrenaline. Nefazodone can also alleviate the adverse effects of stress response on the immune system in mice. Nefazodone has a high affinity for CYP3A4 isoenzymes, indicating a potential risk for active molecule-active molecule interactions.

     Nefazodone Chemical Structure
  12. GC16324 Nefazodone hydrochloride 5-HT2A receptor antagonist Nefazodone hydrochloride Chemical Structure
  13. GC30796 Nelotanserin (APD125) Nelotanserin (APD125) is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. Nelotanserin (APD125) Chemical Structure
  14. GC31018 NEO 376 (SPI-376) NEO 376 (SPI-376) is a selective modulator of 5-HT1 receptor, GABA receptor and dopamine receptor, with anti-psychotic actively. NEO 376 (SPI-376) Chemical Structure
  15. GC32563 Nexopamil racemate Nexopamil racemate is the racemate of Nexopamil. Nexopamil racemate Chemical Structure
  16. GC15872 NPEC-caged-serotonin

    5-HT receptor agonist

     NPEC-caged-serotonin Chemical Structure
  17. GC12744 NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM. NPS ALX Compound 4a dihydrochloride Chemical Structure
  18. GC31015 NRA-0160 NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM). NRA-0160 Chemical Structure
  19. GC31173 Ocaperidone (R79598) Ocaperidone (R79598) is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A. Ocaperidone (R79598) Chemical Structure
  20. GC12495 Olanzapine Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine Chemical Structure
  21. GC16142 Ondansetron serotonin 5-HT3 receptor antagonist Ondansetron Chemical Structure
  22. GC11814 Ondansetron HCl Ondansetron HCl (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. Ondansetron HCl Chemical Structure
  23. GC11651 Ondansetron hydrochloride dihydrate 5-HT3 receptor antagonist Ondansetron hydrochloride dihydrate Chemical Structure
  24. GC15268 Org 12962 hydrochloride 5-HT2C receptor agonist Org 12962 hydrochloride Chemical Structure
  25. GC11338 Org 37684 5-HT2 receptors agonist Org 37684 Chemical Structure
  26. GC38828 Org-12962 Org-12962 is a potent, selective and orally active 5-HT2C?receptor agonist with a pEC50?value of 7.01. Org-12962 Chemical Structure
  27. GC36844 Palonosetron Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Palonosetron Chemical Structure
  28. GC17917 Palonosetron HCl Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Palonosetron HCl Chemical Structure
  29. GC31022 Pancopride (LAS 30451) Pancopride (LAS 30451) is a new potent and selective 5-HT3 receptor antagonist. Pancopride (LAS 30451) Chemical Structure
  30. GC31069 Pardoprunox (SLV-308) Pardoprunox (SLV-308) (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively. Pardoprunox (SLV-308) Chemical Structure
  31. GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride) Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively. Pardoprunox hydrochloride (SLV-308 hydrochloride) Chemical Structure
  32. GC31767 Peptide 401 Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT). Peptide 401 Chemical Structure
  33. GC12293 Perphenazine dopamine antagonist Perphenazine Chemical Structure
  34. GC36875 Perphenazine D8 Dihydrochloride Perphenazine D8 Dihydrochloride is the deuterium labeled Perphenazine, which is a typical antipsychotic drug(5-HT, Dopamine receptor ligand). Perphenazine D8 Dihydrochloride Chemical Structure
  35. GC45791 PF-04995274 A partial 5-HT4 agonist PF-04995274 Chemical Structure
  36. GC30953 Phenylbiguanide (N-Phenylbiguanide) Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. Phenylbiguanide (N-Phenylbiguanide) Chemical Structure
  37. GC19294 Piboserod Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist. Piboserod Chemical Structure
  38. GC36912 Piboserod hydrochloride Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist. Piboserod hydrochloride Chemical Structure
  39. GC11844 Pimavanserin

    5-HT2A inverse agonist

     Pimavanserin Chemical Structure
  40. GC36919 Pimavanserin tartrate Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively. Pimavanserin tartrate Chemical Structure
  41. GC30999 Pimethixene (Pimetixene) Pimethixene (Pimetixene) is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene (Pimetixene) Chemical Structure
  42. GC65296 Pimethixene maleate Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate Chemical Structure
  43. GC17734 Pindolol

    β-adrenoceptor antagonist with partial agonist activity

     Pindolol Chemical Structure
  44. GC36924 Pipamperone Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone Chemical Structure
  45. GC25756 Pirenperone Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg). Pirenperone Chemical Structure
  46. GC13053 Pizotifen Highly selective 5-HT receptor blocking agent Pizotifen Chemical Structure
  47. GC13478 Pizotifen Malate 5-HT receptor antagonist Pizotifen Malate Chemical Structure
  48. GC15011 PNU 109291 5-HT1D receptor agonist PNU 109291 Chemical Structure
  49. GC17854 PNU 142633 5-HT1D receptor agonist PNU 142633 Chemical Structure
  50. GC17714 PNU 22394 hydrochloride 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist PNU 22394 hydrochloride Chemical Structure
  51. GC11714 Prucalopride 5-HT4A and 5-HT4B receptor agonist Prucalopride Chemical Structure
  52. GC13291 Prucalopride Succinat Prucalopride Succinat is a selective, high affinity 5-HT4 receptor agonist with pKi of 8.6/8.1 for 5-HT4a/4b. Prucalopride Succinat Chemical Structure
  53. GC10450 PRX-08066 5-HT2BR antagonist PRX-08066 Chemical Structure
  54. GC16788 PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective PRX-08066 Maleic acid Chemical Structure
  55. GC32595 PRX933 hydrochloride (GW876167 hydrochloride) PRX933 hydrochloride (GW876167 hydrochloride) is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1. PRX933 hydrochloride (GW876167 hydrochloride) Chemical Structure
  56. GC17857 PU 02 negative allosteric modulator of 5-HT3 receptors PU 02 Chemical Structure
  57. GC31393 Pumosetrag Hydrochloride (MKC-733) Pumosetrag Hydrochloride (MKC-733) (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. Pumosetrag Hydrochloride (MKC-733) Chemical Structure
  58. GC37055 Quetiapine D4 fumarate Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine D4 fumarate Chemical Structure
  59. GC16891 Quetiapine Fumarate Quetiapine Fumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine Fumarate Chemical Structure
  60. GC16506 Quipazine dimaleate 5-HT3 receptor agonist Quipazine dimaleate Chemical Structure
  61. GC13369 R 1485 dihydrochloride 5-HT6 antagonist,selective and high affinity R 1485 dihydrochloride Chemical Structure
  62. GC14583 R 59-022 Diacylglycerol (DAG) kinase inhibitor R 59-022 Chemical Structure
  63. GC17706 R-96544 hydrochloride 5-HT2 receptor antagonist R-96544 hydrochloride Chemical Structure
  64. GC15639 Ramosetron Hydrochloride 5-HT3 receptor antagonist Ramosetron Hydrochloride Chemical Structure
  65. GC67923 Renzapride Renzapride Chemical Structure
  66. GC64423 Repinotan hydrochloride Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride Chemical Structure
  67. GC30681 Revexepride Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease. Revexepride Chemical Structure
  68. GC34158 RG-12915 RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM. RG-12915 Chemical Structure
  69. GC12986 Risperidone

    SR-2A inhibitor

     Risperidone Chemical Structure
  70. GC37539 Risperidone hydrochloride Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Risperidone hydrochloride Chemical Structure
  71. GC37540 Risperidone mesylate Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Risperidone mesylate Chemical Structure
  72. GC13883 Ritanserin long-acting 5-HT2 receptor antagonist Ritanserin Chemical Structure
  73. GC10460 Rizatriptan Benzoate 5-HT Receptor agonist Rizatriptan Benzoate Chemical Structure
  74. GC17260 Ro 04-6790 5-HT6 receptor antagonist Ro 04-6790 Chemical Structure
  75. GC15135 Ro 60-0175 fumarate 5-HT2 receptor agonist Ro 60-0175 fumarate Chemical Structure
  76. GC64606 Ro60-0175 Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 Chemical Structure
  77. GC63842 Rodatristat Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. Rodatristat Chemical Structure
  78. GC30206 Roluperidone (CYR-101) Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively). Roluperidone (CYR-101) Chemical Structure
  79. GC14657 Rotundine Dopamine D1 receptor antagonist,potent and selective Rotundine Chemical Structure
  80. GC15979 RS 16566 dihydrochloride

    ligand for the (R)-zacopride binding site

     RS 16566 dihydrochloride Chemical Structure
  81. GC16861 RS 23597-190 hydrochloride 5-HT4 receptor antagonist RS 23597-190 hydrochloride Chemical Structure
  82. GC14625 RS 39604 hydrochloride RS 39604 hydrochloride is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 hydrochloride Chemical Structure
  83. GC15137 RS 56812 hydrochloride

    5-HT3 partial agonist

     RS 56812 hydrochloride Chemical Structure
  84. GC12340 RS 67333 hydrochloride

    potent and highly selective 5-HT4 partial agonist

     RS 67333 hydrochloride Chemical Structure
  85. GC14696 RS 67506 hydrochloride potent and selective 5-HT4 partial agonist RS 67506 hydrochloride Chemical Structure
  86. GC37569 RU 24969 RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 Chemical Structure
  87. GC31827 Rupatadine (UR-12592) Rupatadine (UR-12592) (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine (UR-12592) Chemical Structure
  88. GC11033 Rupatadine Fumarate Inhibitor of PAF and histamine (H1) receptor Rupatadine Fumarate Chemical Structure
  89. GC10535 S 32212 hydrochloride inverse agonist of 5-HT2C receptors S 32212 hydrochloride Chemical Structure
  90. GC64530 Sarizotan Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan Chemical Structure
  91. GC16202 Sarpogrelate hydrochloride 5-HT2A receptor inhibitor Sarpogrelate hydrochloride Chemical Structure
  92. GC25898 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo. SB 200646 Chemical Structure
  93. GC14052 SB 200646 hydrochloride 5-HT2C/2B receptor antagonist SB 200646 hydrochloride Chemical Structure
  94. GC16439 SB 203186 hydrochloride Potent 5-HT4 receptor antagonist SB 203186 hydrochloride Chemical Structure
  95. GC10401 SB 204070 Potent and selective 5-HT4 receptor antagonist SB 204070 Chemical Structure
  96. GC12803 SB 204741 5-HT2B receptor antagonist SB 204741 Chemical Structure
  97. GC10310 SB 206553 hydrochloride

    5-HT2B/5-HT2C receptor antagonist

     SB 206553 hydrochloride Chemical Structure
  98. GC15551 SB 216641 hydrochloride h5-HT1B antagonist SB 216641 hydrochloride Chemical Structure
  99. GC16556 SB 221284 5-HT2C/2B receptor antagonist SB 221284 Chemical Structure
  100. GC13438 SB 224289 hydrochloride 5-HT1B receptor antagonist SB 224289 hydrochloride Chemical Structure
  101. GC14347 SB 228357 5-HT2C/2B receptor antagonist SB 228357 Chemical Structure

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