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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Potassium Channel

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Products for  Potassium Channel

  1. Cat.No. Product Name Information
  2. GC16036 Repaglinide Kir6 (KATP) channel blocker Repaglinide Chemical Structure
  3. GC14029 Retigabine Activator of voltage-gated potassium channel, an anticonvulsant agent Retigabine Chemical Structure
  4. GC63482 Rimtuzalcap Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap Chemical Structure
  5. GC69820 RL648_81

    RL648_81 is a specific activator of the KQT-like subfamily 2/3 (KCNQ2/3) with an EC50 of 190 nM. RL648_81 effectively shifts the V1/2 of KCNQ2/3 channels to more hyperpolarized potentials, but has no effect on KCNQ4 or KCNQ5. RL648_81 has potential for research in neurological disorders associated with neuronal hyperexcitability.

     RL648_81 Chemical Structure
  6. GC61250 Ropivacaine Ropivacain is a potent?sodium channel?blocker. Ropivacaine Chemical Structure
  7. GC14932 Ropivacaine HCl Ropivacaine HCl is a potentsodium channelblocker and blocks impulse conduction via reversible inhibition ofsodium ion influxin nerve fibrese. Ropivacaine HCl Chemical Structure
  8. GC39843 Ropivacaine mesylate Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine mesylate Chemical Structure
  9. GC16359 Rosuvastatin Competitive inhibitor of HMG-CoA reductase Rosuvastatin Chemical Structure
  10. GC15736 Rosuvastatin Calcium HMG-CoA reductase inhibitor Rosuvastatin Calcium Chemical Structure
  11. GC61251 Rosuvastatin D3 Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin D3 Chemical Structure
  12. GC32509 RPR-260243 RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR-260243 Chemical Structure
  13. GC65280 RU-TRAAK-2 RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor. RU-TRAAK-2 Chemical Structure
  14. GC14646 RuBi-4AP voltage-dependent K+ channel blocker RuBi-4AP Chemical Structure
  15. GC39053 Saikogenin D Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D Chemical Structure
  16. GC45564 Sematilide (hydrochloride)   Sematilide (hydrochloride) Chemical Structure
  17. GC37628 Senicapoc An inhibitor of IKCa1/KCa3.1 channels Senicapoc Chemical Structure
  18. GC14297 ShK-Dap22 Extremely potent KV1.3 channel blocker ShK-Dap22 Chemical Structure
  19. GC38048 Sigma-1 receptor antagonist 3 Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 Chemical Structure
  20. GC14790 SKA 31 Activator of KCa3.1 and KCa2 channels SKA 31 Chemical Structure
  21. GC19004 SKA-121 SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1) with an EC50 value of 109 nM using whole-cell patch-clamp electrophysiology with calcium in the internal solution. SKA-121 Chemical Structure
  22. GC15631 Sotalol hydrochloride β-adrenergic receptor antagonist Sotalol hydrochloride Chemical Structure
  23. GC45893 Sotalol-d6 (hydrochloride) An internal standard for the quantification of sotalol Sotalol-d6 (hydrochloride) Chemical Structure
  24. GC13353 Spadin TREK-1 channel inhibitor Spadin Chemical Structure
  25. GC61288 Spadin TFA Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA Chemical Structure
  26. GC45573 Talatisamine   Talatisamine Chemical Structure
  27. GC31686 Tannic acid Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. Tannic acid Chemical Structure
  28. GC69992 TASK-1-IN-1

    TASK-1-IN-1 is an effective selective inhibitor of TASK-1 (Potassium Channel), with an IC50 of 148 nM. The inhibitory effect of TASK-1-IN-1 on the TASK-3 channel (IC50 of 1750 nM) decreases, and it has no significant impact on other K+ channels. TASK-1-IN-1 also has anti-cancer properties.

     TASK-1-IN-1 Chemical Structure
  29. GC10978 Terfenadine Histamine H1-receptor antagonist Terfenadine Chemical Structure
  30. GC13819 Tertiapin LQ Kir1.1 channel blocker Tertiapin LQ Chemical Structure
  31. GC10515 Tertiapin-Q high affinity blocker for inward-rectifier K+ channels Tertiapin-Q Chemical Structure
  32. GC10953 Tetraethylammonium chloride K+ channel blocker Tetraethylammonium chloride Chemical Structure
  33. GN10446 Tetrandrine Tetrandrine Chemical Structure
  34. GC38952 Tifenazoxide Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide Chemical Structure
  35. GC38391 Tipepidine hydrochloride Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride Chemical Structure
  36. GC10424 Tolbutamide first generation potassium channel blocker Tolbutamide Chemical Structure
  37. GC14705 Tolbutamide Sodium potassium channel blocker Tolbutamide Sodium Chemical Structure
  38. GC16149 Topiramate An anticonvulsant Topiramate Chemical Structure
  39. GC50198 Topiramate - d12 Deuterated topiramate Topiramate - d12 Chemical Structure
  40. GC50664 TRPV3 74a TRPV3 74a is a potent and selective TRPV3 antagonist. TRPV3 74a Chemical Structure
  41. GC32660 U89232 U-89232 appears to be a cardioselective KATP channel opener. U89232 Chemical Structure
  42. GC15900 UCL 1684 UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 Chemical Structure
  43. GC13188 UCL 2077 Slow afterhyperpolarization (sAHP) channel blocker,KCNQ1 and KCNQ2 inhibitor UCL 2077 Chemical Structure
  44. GC17787 UK 78282 hydrochloride KV1.3 and KV1.4 voltage-gated potassium channel blocker UK 78282 hydrochloride Chemical Structure
  45. GC41248 Unoprostone

    Unoprostone is an analog of PGF2α with a 13,14-dihydro-15-keto modification and a two-carbon extension of the aliphatic lower side chain.

     Unoprostone Chemical Structure
  46. GC16948 Valinomycin Valinomycin is a cyclic depsipeptide antibiotic with potassium selective ionophoric activity. It can be used as uncoupling agent to induce depolarization.. Valinomycin Chemical Structure
  47. GC37897 Vernakalant Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic. Vernakalant Chemical Structure
  48. GC10038 Vernakalant Hydrochloride Vernakalant Hydrochloride Chemical Structure
  49. GC17001 Verruculogen

    Maxi-K potassium channels inhibitor

     Verruculogen Chemical Structure
  50. GC37927 VU 0240551 A KCC2 cotransporter inhibitor VU 0240551 Chemical Structure
  51. GC15369 VU 590 dihydrochloride VU 590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU 590 dihydrochloride Chemical Structure
  52. GC13455 VU 591 hydrochloride renal outer medullary potassium channel (Kir1.1, ROMK) antagonist VU 591 hydrochloride Chemical Structure
  53. GC18629 VU0071063 VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 uM using whole cell patch clamp electrophysiology). VU0071063 Chemical Structure
  54. GC62163 VU041 VU041 is a first submicromolar-affinity inhibitor of Anopheles (An. VU041 Chemical Structure
  55. GC33689 VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM. VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) Chemical Structure
  56. GC61379 VU0463271 quarterhydrate VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC50 of 61 nM. VU0463271 quarterhydrate Chemical Structure
  57. GC65125 VU0529331 VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 ?M and 5.2 ?M for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel. VU0529331 Chemical Structure
  58. GC39459 VU0810464 VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 Chemical Structure
  59. GC11351 VU590 (hydrochloride) inhibitor of KCNJ1 VU590 (hydrochloride) Chemical Structure
  60. GC37930 VU591 VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM. VU591 Chemical Structure
  61. GC70136 VU6036720 hydrochloride

    VU6036720 hydrochloride is an effective and specific Kir4.1/5.1 inhibitor in vitro. It can inhibit Kir4.1/5.1 channels with an IC50 value of 0.24 μM. VU6036720 hydrochloride can be used for research on the brain and kidneys.

     VU6036720 hydrochloride Chemical Structure
  62. GC11919 XE 991 dihydrochloride KV7 (KCNQ) voltage-gated potassium channels blocker XE 991 dihydrochloride Chemical Structure
  63. GC11132 Y-26763 Kir6 (KATP) channel opener Y-26763 Chemical Structure
  64. GC16690 Y-27152 Prodrug of the Kir6 (KATP) channel opener Y-26763 Y-27152 Chemical Structure
  65. GC32501 YM758 YM758 is a “funny” If current channel (If channel) inhibitor. YM758 Chemical Structure
  66. GC17518 YS-035 hydrochloride inhibitor of outward K+ currents YS-035 hydrochloride Chemical Structure
  67. GC17264 ZM 226600 Kir6 (KATP) channel opener ZM 226600 Chemical Structure

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