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Home >> Signaling Pathways >> Others >> SGK

SGK

SGK (serine/threonine-protein kinase) is important in activating certain potassium, sodium, and chloride channels.

Products for  SGK

  1. Cat.No. Product Name Information
  2. GC38755 CKI-7 CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases. CKI-7 Chemical Structure
  3. GC17986 EMD638683 An inhibitor of SGK1 EMD638683 Chemical Structure
  4. GC35977 EMD638683 R-Form EMD638683 R-Form is the R-form of EMD638683. EMD638683 R-Form Chemical Structure
  5. GC35978 EMD638683 S-Form EMD638683 (S-Form) is a SGK1 inhibitor with an IC50 of >300 nM. EMD638683 S-Form Chemical Structure
  6. GC15441 GSK 650394 SGK1 inhibitor GSK 650394 Chemical Structure
  7. GC73111 HaloPROTAC-E HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM HaloPROTAC-E Chemical Structure
  8. GC39426 PROTAC SGK3 degrader-1

    SGK3-PROTAC1

     PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate). PROTAC SGK3 degrader-1 Chemical Structure
  9. GC30673 SGK1-IN-1 SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. SGK1-IN-1 Chemical Structure
  10. GC62431 SGK1-IN-2 SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration. SGK1-IN-2 Chemical Structure
  11. GC73088 SGK1-IN-3 hydrochloride SGK1-IN-3 drochloride (compound 3a) is a potent and orally active inhibitor of SGK1. SGK1-IN-3 hydrochloride Chemical Structure
  12. GC64706 SGK1-IN-4 SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 Chemical Structure

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