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AR7 Catalog No.GC19035

Size Price Stock Qty
5mg
$43.00
In stock
10mg
$72.00
In stock
25mg
$156.00
In stock
50mg
$273.00
In stock
100mg
$488.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Chemical Properties

Cas No. 80306-38-3 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
Formula C15H12ClNO M.Wt 257.71
Solubility DMSO : 25 mg/mL (97.01 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

AR7 is a retinoic acid receptor α (RARα) antagonist.

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA [1].

References:
[1]. Anguiano J, et al. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82.