Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Targets for Drug Metabolite
Products for Drug Metabolite
- Cat.No. Product Name Information
- GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
- GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion.
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC46284 (±)-Cotinine-d3 An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
- GC41315 (±)-Ketoprofen Glucuronide (±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.
- GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine
- GC45252 (-)-Sitagliptin Carbamoyl Glucuronide (-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin.
- GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine .
-
GC68509
(25R)-12α-Hydroxyspirost-4-en-3-one
(25R)-12α-Hydroxyspirost-4-en-3-one is a secondary metabolite produced by Nocardia globerula from Hecogenin.
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
- GC60399 (E)-10-Hydroxynortriptyline (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline.
- GC40286 (E,Z)-2-propyl-2-Pentenoic Acid (E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.
- GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
- GC62737 (R)-(-)-O-Desmethyl Venlafaxine D6
- GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
- GC60410 (Rac)-3′-Hydroxy simvastatin (Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC60419 (S)-O-Desmethyl Venlafaxine N-Oxide (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine.
- GC60427 (Z)-10-Hydroxynortriptyline (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline.
- GC67761 (Z)-10-Hydroxynortriptyline-d3
-
GC18596
(±)-2-propyl-4-Pentenoic Acid
(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid .
- GC41995 1'-hydroxy Midazolam Major metabolite of the anesthetic, midazolam
-
GC41837
1,3,7-Trimethyluric Acid
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
- GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid
- GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
- GC66057 10,11-Dihydrocarbamazepine 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
- GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
- GC49759 13C17-Mycophenolic Acid An internal standard for the quantification of mycophenolic acid
- GC19442 15-Acetyldeoxy Nivalenol 15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops.
- GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
- GC41309 16α-hydroxy Prednisolone 16α-hydroxy Prednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide.
- GC41300 17β-hydroxy Exemestane 17β-hydroxy Exemestane is the primary active metabolite of exemestane.
- GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
- GC46508 2',2'-Difluoro-2'-deoxyuridine An active metabolite of gemcitabine
- GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones
- GC49330 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride) A metabolite of mazindol
- GC52029 2-Aminoflubendazole
- GC46539 2-Chloroadenine A heterocyclic building block
- GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
- GC35090 2-Hydroxy atorvastatin calcium salt An active metabolite of atorvastatin
- GC60474 2-Hydroxy atorvastatin lactone 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin.
- GC64336 2-Hydroxyemodin 2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes.
- GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
- GC40968 21-hydroxy Eplerenone 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone.
- GC35079 24, 25-Dihydroxy VD2 24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.
- GC49365 25-Desacetyl Rifampicin A major active metabolite of rifampicin
- GC41480 3'-hydroxy Lidocaine 3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
- GC39611 3'-Hydroxy Repaglinide 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide.
- GC60500 3'-Hydroxy Repaglinide D5 3'-Hydroxy Repaglinide D5 is the deuterium labeled 3'-Hydroxy Repaglinide.
- GC68082 3,4,5-Trimethoxyphenylacetic acid
- GC39841 3,4-Dehydro Cilostazol 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol.
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC42198 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt) An inactive metabolite of baclofen
- GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide
- GC67902 3-Amino-2-oxazolidinone-d4
- GC42274 3-hydroxy Darifenacin 3-hydroxy Darifenacin is a metabolite of darifenacin.
- GC42275 3-hydroxy Desloratidine 3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
- GC41565 3-hydroxy Medetomidine 3-hydroxy Medetomidine is a metabolite of the α2-adrenergic receptor agonist medetomidine.
- GC48457 3-keto Fusidic Acid An active metabolite of fusidic acid
- GC33738 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
- GC68324 3-Methoxytyramine-d4 hydrochloride
- GC49869 3-Methoxytyrosine An active metabolite of L-DOPA
- GC42307 3-O-methyl-L-DOPA (hydrate) 3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
- GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine
- GC49252 4’-hydroxy Trazodone A metabolite of trazodone
- GC18527 4'-hydroxy Flurbiprofen A major active metabolite of flurbiprofen
- GC49752 4,5-Desisopropylidene Topiramate An inactive metabolite of topiramate
- GC49337 4-Acetamidobenzenesulfonamide A metabolite of asulam and sulfanilamide
- GC42370 4-desmethoxy Omeprazole 4-desmethoxy Omeprazole is a potential impurity found in commercial omeprazole and esomeprazole magnesium preparations.
- GC18194 4-Epidoxycycline 4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline .
- GC42401 4-hydroperoxy Cyclophosphamide An activated analog of cyclophosphamide
- GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC18425
4-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC42407
4-hydroxy Diclofenac
4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac.
- GC49575 4-hydroxy Omeprazole sulfide A metabolite of omeprazole
- GC40879 4-hydroxy Solifenacin N-oxide 4-hydroxy Solifenacin N-oxide is an N-oxide form of 4-hydroxy solifenacin, the major metabolite of solifenacin .
- GC42415 4-hydroxy Valsartan 4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.
- GC18417 4-hydroxy Xylazine 4-hydroxy Xylazine is a metabolite of xylazine .
- GC39307 4-Methylamino antipyrine 4-Methylamino antipyrine is an active metabolite of Metamizole.
- GC60523 4-Methylamino antipyrine hydrochloride An active metabolite of metamizole
- GC49127 4-oxo Cyclophosphamide An inactive metabolite of cyclophosphamide
- GC41399 5α-dihydro Levonorgestrel 5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel.
- GC18582 5'-hydroxy Meloxicam A metabolite of meloxicam
-
GC18542
5,6-dihydro-5-Fluorouracil
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).
- GC18466 5,6-epoxy-13-cis Retinoic Acid 5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid.
- GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
- GC49655 5-hydroxy Buspirone A metabolite of buspirone
- GC42546 5-hydroxy Diclofenac 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4.
- GC49119 5-hydroxy Flunixin A metabolite of flunixin
- GC49315 5-hydroxy Indomethacin A metabolite of indomethacin
-
GC41312
5-hydroxy Omeprazole
5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.
- GC42549 5-hydroxy Thiabendazole 5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.
- GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.
- GC42551 5-hydroxymethyl Tolterodine (formate) 5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.
- GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8.
- GC49676 6β-hydroxy Budesonide A metabolite of budesonide