Home>>Graphislactone A
Graphislactone A Catalog No.GC18788

Size Price Stock Qty
1mg
$315.00
In stock
5mg
$1,104.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 52179-44-9 SDF Download SDF
Synonyms N/A
Chemical Name 4,7-dihydroxy-3,9-dimethoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
Canonical SMILES O=C1OC2=C(O)C(OC)=CC(C)=C2C3=C1C(O)=CC(OC)=C3
Formula C16H14O6 M.Wt 302.3
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. olivacea. It exhibits dose-dependent scavenging activity against DPPH radicals and metal ion-dependent hydroxyl radicals in vitro. Graphislactone A reduces peroxidation of human LDL and slows peroxidation of linoleic acid by 4.4-fold. It also inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM.

References:
[1]. Song, Y.C., Huang, W.Y., Sun, C., et al. Characterization of graphislactone A as the antioxidant and free radical-scavenging substance from the culture of Cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides Biol. Pharm. Bull. 28(3), 506-509 (2005).
[2]. Hormazabal, E., Schmeda-Hirschmann, G., Astudillo, L., et al. Metabolites from Microsphaeropsis olivacea, an endophytic fungus of Pilgerodendron uviferum Z. Naturforsch. C. 60(1-2), 11-21 (2005).