Morusin
Catalog No.: GN10436Purity:>98.50%Synonyms: Mulberrochromene, NSC 649220
Morusin is a significant prenylated flavone found in Morus alba (Moraceae) root cortex, which exhibits significant anti-tumor activity in the treatment of prostate cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 62596-29-6
10mM (in 1mL DMSO)In Stock
$44.00
1
5mgIn Stock
$40.00
1
10mgIn Stock
$64.00
1
25mgIn Stock
$120.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $44.00 | In Stock | 1 | |
| 5mg | $40.00 | In Stock | 1 | |
| 10mg | $64.00 | In Stock | 1 | |
| 25mg | $120.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
Morusin is a significant prenylated flavone found in Morus alba (Moraceae) root cortex, which exhibits significant anti-tumor activity in the treatment of prostate cancer[1]. Prenylated flavonoids, a unique class of flavonoids which combine a flavonoid skeleton and a lipophilic prenyl side-chain, possess great potential biological activities including cytotoxicity, anti-inflammation, anti-Alzheimer, anti-diabetes and other effects[2]. Morusin as a candidate for the new efficacious mucoregualtors for inflammatory pulmonary diseases[3].
In vitro, treatment of PC3 cells with morusin (0-10μM) for 48h significantly inhibited cell viability in a time- and concentration-dependent manner and reduced levels of inflammatory cytokines[4]. In NCI-H292 cells deprived of serum for 24h, morusin (1-100μM) administered for 30minutes significantly suppressed the production of mucin 5AC (MUC5AC), thereby controlling various pulmonary inflammatory responses caused by excessive mucus secretion[3]. In cancer cell lines (MKN45 and SGC7901) treated with moracin (1-5mg/L) for 72h, moracin effectively inhibited cancer cell growth and proliferation in a dose-dependent manner[5].
In vivo, administration of morusin (5mg/kg/5days) via intragastric administration for 28days in ovariectomized rats, morusin alleviated estrogen deficiency-induced osteoporosis and reduced the expression of RUNX2 and β-catenin in femoral bone tissue[6]. In a destabilization of the medial meniscus osteoarthritis (DMM) mouse model, administration of morusin (5mg/kg/2days) via intragastric administration for 56days, morusin mitigated cartilage erosion and destruction while decreasing the expression levels of associated inflammatory factors and proteins[7].
References:
[1] Dirir A M, Daou M, Yousef A F, et al. A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes[J]. Phytochem Rev, 2022, 21(4): 1049-1079.
[2] Shi S, Li J, Zhao X, et al. A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids[J]. Phytochemistry, 2021, 191: 112895.
[3] Lee H J, Ryu J, Park S H, et al. Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin[J]. Tuberc Respir Dis (Seoul), 2014, 77(2): 65-72.
[4] Fadil S A, Albadawi D a I, Alshali K Z, et al. Modulation of inflammatory mediators underlies the antitumor effect of the combination of morusin and docetaxel on prostate cancer cells[J]. Biomed Pharmacother, 2024, 180: 117572.
[5] Wang F, Zhang D, Mao J, et al. Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer[J]. Oncotarget, 2017, 8(34): 57187-57200.
[6] Chen M, Han H, Zhou S, et al. Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model[J]. Stem Cell Res Ther, 2021, 12(1): 173.
[7] Jia Y, He W, Zhang H, et al. Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway[J]. Drug Des Devel Ther, 2020, 14: 1227-1240.
Protocol
| Cell experiment [1]: | |
Cell lines | PC3 (Human Prostate Cancer Cells) |
Preparation Method | In 96-well culture plates, PC3 cells were planted at a density of 4×104 cells/well. They were cultured for 24h to allow them to stick to the plates before being subjected to the medications. Serial dilutions of morusin (0, 1.25, 2.5, 5, 10µM) was applied to the cells to measure the inhibitory concentration 50. Following a 48h treatment period, the cells were immobilized by applying 10% trichloroacetic acid at a temperature of 4℃ for a duration of 1h. Afterwards, the cells were treated with Sulforhodamine-B (0.4%) for a duration of 30minutes, then rinsed with 1% acetic acid and allowed to dry in the air. The dye was eliminated by rinsing the plate with a solution of 10mM tris base at a pH of 10.5. Subsequently, the optical density of the wells was quantified at a wavelength of 570nm using an ELISA microplate reader. |
Reaction Conditions | 0, 1.25, 2.5, 5, and 10μM; 48h |
Applications | Morusin significantly inhibited cell viability and reduced levels of inflammatory cytokines. |
| Animal experiment [2]: | |
Animal models | C57BL/6 mice (males and females) |
Preparation Method | Mice were randomly divided into three groups (Sham group, DMM group and morusin treated group), and were anesthetized, at which the mice knee joints were carefully, and aseptically, exposed with a scalpel, followed by resectioning of the medial meniscuses. The wound was later sutured carefully, and penicillin was injected intramuscularly for the following 3days. The mourusin-treated group was administered morusin, dissolved in saline (40mg/kg), intragastrically once every 2days for 8weeks; while mice in the Sham and DMM groups received 5% DMSO (dimethyl-sulfoxide) in saline once every 2days for 8weeks. |
Dosage form | 40mg/kg/2days for 56days; Intragastric administration |
Applications | Morusin mitigated cartilage erosion and destruction and decreased the expression levels of associated inflammatory factors and proteins. |
References: | |
Product Documents
Purity:>98.50%Appearance:A solid
Chemical Properties
CAS No.
62596-29-6
Synonyms
Mulberrochromene, NSC 649220
Chemical Name
2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
SMILES
CC(=CCC1=C(OC2=C3C=CC(OC3=CC(=C2C1=O)O)(C)C)C4=C(C=C(C=C4)O)O)C
Molecular Formula
C25H24O6
Molecular Weight
420.47
Solubility
≥ 49.3mg/mL in DMSO
Storage
Store at -20°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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