FKBP
FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.
FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.
Targets for FKBP
Products for FKBP
- Cat.No. Product Name Information
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GC34172
AP1867
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GC61745
AP1867-2-(carboxymethoxy)
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GC15586
AP1903
Homodimer binding to FKBP
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GC14498
AP20187
Dimerizer,synthetic and cell-permeable
-
GC13215
Ascomycin(FK 520)
Macrolide immunosuppressant,FK-520 analog
-
GC13601
Everolimus (RAD001)
A MTOR inhibitor
-
GC62186
KB02-SLF
-
GC39503
PROTAC FKBP Degrader-3
-
GC15031
Rapamycin (Sirolimus)
Original antifungal antibiotic
-
GC33699
SAFit1
-
GC34093
SAFit2
-
GC38060
Shield-1
-
GC44899
SLF
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12).
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GC61461
SLF TFA
-
GC16233
Tacrolimus (FK506)
Macrolide calcineurin inhibitor,immunosuppressant
-
GC17995
Tacrolimus monohydrate
immunosuppressive drug
-
GC33200
Target Protein-binding moiety 13