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FKBP (FK506-binding protein) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity. Small size FKBP family members contain only FK506-binding domain, while FKBPs with large molecular weights possess extra domains such as tetratricopeptide repeat domains, calmodulin binding and transmembrane motifs. FKBPs are involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP family proteins play important functional roles in the T-cell activation, when complexed with their ligands.

FK506-binding proteins 1a and 1b (FKBP1a/1b) are immunophilin proteins that bind the immunosuppressant agent FK506 and AY 22989. FKBP12 is a ubiquitous abundant protein that acts as a receptor for FK506, binds tightly to intracellular calcium release channels and to the transforming growth factor β (TGF-β) type I receptor.

Targets for  FKBP

Products for  FKBP

  1. Cat.No. Product Name Information
  2. GC34172 AP1867 AP1867  Chemical Structure
  3. GC61745 AP1867-2-(carboxymethoxy) AP1867-2-(carboxymethoxy)  Chemical Structure
  4. GC15586 AP1903 Homodimer binding to FKBP AP1903  Chemical Structure
  5. GC14498 AP20187 Dimerizer,synthetic and cell-permeable AP20187  Chemical Structure
  6. GC13215 Ascomycin(FK 520) Macrolide immunosuppressant,FK-520 analog Ascomycin(FK 520)  Chemical Structure
  7. GC13601 Everolimus (RAD001) A MTOR inhibitor Everolimus (RAD001)  Chemical Structure
  8. GC62186 KB02-SLF KB02-SLF  Chemical Structure
  9. GC39503 PROTAC FKBP Degrader-3 PROTAC FKBP Degrader-3  Chemical Structure
  10. GC15031 Rapamycin (Sirolimus) Original antifungal antibiotic Rapamycin (Sirolimus)  Chemical Structure
  11. GC33699 SAFit1 SAFit1  Chemical Structure
  12. GC34093 SAFit2 SAFit2  Chemical Structure
  13. GC38060 Shield-1 Shield-1  Chemical Structure
  14. GC44899 SLF FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). SLF  Chemical Structure
  15. GC61461 SLF TFA SLF TFA  Chemical Structure
  16. GC16233 Tacrolimus (FK506) Macrolide calcineurin inhibitor,immunosuppressant Tacrolimus (FK506)  Chemical Structure
  17. GC17995 Tacrolimus monohydrate immunosuppressive drug Tacrolimus monohydrate  Chemical Structure
  18. GC33200 Target Protein-binding moiety 13 Target Protein-binding moiety 13  Chemical Structure

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