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Home >> Signaling Pathways >> Neuroscience >> COX

COX

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

Products for  COX

  1. Cat.No. Product Name Information
  2. GC12684 NCX 4040

    NO-Aspirin

     COX-2 expression inhibitor NCX 4040 Chemical Structure
  3. GC13896 NCX 466 cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor NCX 466 Chemical Structure
  4. GN10429 Neochlorogenic acid

    5-Caffeoylquinic Acid, trans-5-O-Caffeoylquinic Acid, 5-CQA, Neochlorogenic Acid

     Neochlorogenic acid Chemical Structure
  5. GC13637 Nepafenac

    AHR 9434, AL 6515

     COX-1 and COX-2 inhibitor Nepafenac Chemical Structure
  6. GC36721 Nepafenac D5

    AHR 9434-d5, AL 6515-d5

     An internal standard for the quantification of nepafenac Nepafenac D5 Chemical Structure
  7. GC18084 Nimesulide

    R805

     Non-steroidal anti-inflammatory drug Nimesulide Chemical Structure
  8. GC39583 Nimesulide D5

    R805-d5

     An internal standard for the quantification of nimesulide Nimesulide D5 Chemical Structure
  9. GC36747 Nitroaspirin Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins. Nitroaspirin Chemical Structure
  10. GC34028 Nitroflurbiprofen (HCT 1206) Nitroflurbiprofen (HCT 1206) is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. Nitroflurbiprofen (HCT 1206) Chemical Structure
  11. GC44439 NO-Indomethacin

    NCX 2121

     NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. NO-Indomethacin Chemical Structure
  12. GC12241 NS 398 COX-2 inhibitor and anti-inflammatory agent NS 398 Chemical Structure
  13. GC14999 O-Acetyl Salicylhydroxamic Acid

    AcSHA,O-ASHA

     irreversible, non-selective inhibitor of COX-1 and COX-2 O-Acetyl Salicylhydroxamic Acid Chemical Structure
  14. GC49316 O-Desmethyl-N-deschlorobenzoyl Indomethacin A metabolite of indomethacin O-Desmethyl-N-deschlorobenzoyl Indomethacin Chemical Structure
  15. GC63478 Ocarocoxib Ocarocoxib, a potent COX-?2 (cyclooxygenase-?2) inhibitor, is a non-steroidal anti-inflammatory for veterinary use. Ocarocoxib Chemical Structure
  16. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine Olsalazine-13C6 Chemical Structure
  17. GC12114 Oxaprozin

    NSC 310839, Wy 21743

     COX inhibitor Oxaprozin Chemical Structure
  18. GC36828 Oxaprozin D4

    Wy-21743 D4

     Oxaprozin D4 (Wy-21743 D4) is the deuterium labeled Oxaprozin, which is a non-steroidal anti-inflammatory agent (NSAID). Oxaprozin D4 Chemical Structure
  19. GC69640 Oxaprozin-d4

    Oxaprozin-d4 is the deuterated form of Oxaprozin.

     Oxaprozin-d4 Chemical Structure
  20. GC49054 Oxaprozin-d5

    Oxaprozinum-d5; Wy21743-d5

     An internal standard for the quantification of oxaprozin Oxaprozin-d5 Chemical Structure
  21. GC40651 Oxyphenbutazone

    G 27202, p-Hydroxyphenylbutazone, NSC 526053, Ro 04-4410

     Oxyphenbutazone is a metabolite of phenylbutazone. Oxyphenbutazone Chemical Structure
  22. GC32640 Pamicogrel (KBT3022)

    KBT-3022

     Pamicogrel (KBT3022) (KBT3022) is a cyclooxygenase (COX) inhibitor. Pamicogrel (KBT3022) Chemical Structure
  23. GC14849 Paradol A phenolic ketone with diverse biological activities Paradol Chemical Structure
  24. GC36852 Parecoxib Parecoxib (SC 69124) is a highly selective?and orally active COX-2 inhibitor, the prodrug of Valdecoxib. Parecoxib Chemical Structure
  25. GC17051 Parecoxib Sodium

    SC-69124A

     COX-2 inhibitor Parecoxib Sodium Chemical Structure
  26. GC70553 Pelubiprofen Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen Chemical Structure
  27. GC60283 Pentagamavunon-1

    PGV-1

     Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation. Pentagamavunon-1 Chemical Structure
  28. GC44597 Peonidin (chloride)

    Peonidin is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables.

     Peonidin (chloride) Chemical Structure
  29. GC15928 Phenacetin

    p-Acetophenetidide, 4′-Ethoxyacetanilide, NSC 7651

     Non-opioid analgesic Phenacetin Chemical Structure
  30. GC66429 Phenacetin-d5

    Acetophenetidin-d5

     Phenacetin-d5 (Acetophenetidin-d5) is the deuterium labeled Phenacetin. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats. Phenacetin-d5 Chemical Structure
  31. GC61180 Phenidone Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone Chemical Structure
  32. GC15008 Phenylbutazone non-steroidal anti-inflammatory agent Phenylbutazone Chemical Structure
  33. GC65108 Phenylbutazone(diphenyl-d10) Phenylbutazone(diphenyl-d10) Chemical Structure
  34. GC69699 Phenylbutazone-13C12

    Phenylbutazone-13C12 is a labeled form of Phenylbutazone with 13 carbon atoms. Phenylbutazone is an effective reducing co-factor for prostaglandin H synthase (PHS) and peroxidase enzymes. It is a hepatotoxin and a nonsteroidal anti-inflammatory drug (NSAID). Phenylbutazone induces the expression of muscleblind-like protein 1 (MBNL1), which has potential for research in ankylosing spondylitis.

     Phenylbutazone-13C12 Chemical Structure
  35. GC49128 Phenylbutazone-d9 An internal standard for the quantification of phenylbutazone Phenylbutazone-d9 Chemical Structure
  36. GC16790 Piroxicam

    NSC 666076

     Prostaglandin synthesis/Coxinhibitor Piroxicam Chemical Structure
  37. GC61193 Piroxicam D3 An internal standard for the quantification of piroxicam Piroxicam D3 Chemical Structure
  38. GN10395 Prim-O-glucosylcimifugin

    1''-O-Glucosylcimifugin, PGCN

     Prim-O-glucosylcimifugin Chemical Structure
  39. GC66258 Propacetamol Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders. Propacetamol Chemical Structure
  40. GC19706 Propacetamol hydrochloride Propacetamol hydrochloride Chemical Structure
  41. GC33876 Propyphenazone (4-Isopropylantipyrine) Propyphenazone (4-Isopropylantipyrine) is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone (4-Isopropylantipyrine)-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. Propyphenazone (4-Isopropylantipyrine) Chemical Structure
  42. GC71602 Propyphenazone-d3 Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone-d3 Chemical Structure
  43. GC14847 Psoralidin apoptosis inducer Psoralidin Chemical Structure
  44. GC60311 PTUPB PTUPB is a novel dual COX-2 and sEH inhibitor with IC50 values of 1.26 nM and 0.9 μM, respectively. PTUPB Chemical Structure
  45. GC17367 Rebamipide

    OPC 12759

     cholecystokinin type 1 (CCK1) receptor inhibitor Rebamipide Chemical Structure
  46. GC61234 Rebamipide D4 An internal standard for the quantification of rebamipide Rebamipide D4 Chemical Structure
  47. GC63398 Rebamipide mofetil Rebamipide mofetil is an orally active prodrug of Rebamipide (OPC12759). Rebamipide mofetil Chemical Structure
  48. GC61235 Regaloside B Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B Chemical Structure
  49. GC33468 Rehmannioside A Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC50 values of 10.08, 12.62, and 16.43μM, respectively. Rehmannioside A Chemical Structure
  50. GC61238 Rehmapicrogenin

    Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6.

     Rehmapicrogenin Chemical Structure
  51. GC38198 Revaprazan hydrochloride Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride Chemical Structure
  52. GC12411 RHC 80267

    U-57908

     RHC 80267 is a potent and selective diacylglycerol lipase (DAGL) inhibitor. RHC 80267 can also inhibit cholinesterase activity (IC₅₀= 4µM), suppress cyclooxygenase (COX) activity, and inhibit phosphatidylcholine hydrolysis. RHC 80267 Chemical Structure
  53. GC38151 Roburic acid Roburic acid Chemical Structure
  54. GC10516 Rofecoxib

    MK-966

     COX-2 inhibitor Rofecoxib Chemical Structure
  55. GC45823 Rofecoxib-d5 An internal standard for the quantification of rofecoxib Rofecoxib-d5 Chemical Structure
  56. GN10039 Rutaecarpine

    NSC 258317

     Rutaecarpine is an indolopyridoquinazoline alkaloid isolated from Evodia rutaecarpa and known to inhibit COX-2 with an IC50 of 0.28μM at the cellular level. Rutaecarpine Chemical Structure
  57. GC31813 RWJ 63556 RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities. RWJ 63556 Chemical Structure
  58. GC30027 S-(+)-Marmesin ((+)-Marmesin)

    (+)-Marmesin, (S)-Marmesin, NSC 340840

     S-(+)-Marmesin ((+)-Marmesin) is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity. S-(+)-Marmesin ((+)-Marmesin) Chemical Structure
  59. GC31835 S-2474 S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug. S-2474 Chemical Structure
  60. GC16508 Salicylic acid

    2-Hydroxybenzoic Acid, NSC 180

     Salicylic acid is a natural phenolic plant defense hormone and a medicinal molecule with keratolytic activity. Salicylic acid Chemical Structure
  61. GC74187 Salicylic acid-13C6

    2-Hydroxybenzoic acid-13C6

     Salicylic acid-13C6 is the 13C-labeled Salicylic acid. Salicylic acid-13C6 Chemical Structure
  62. GC49480 Salicylic Acid-d4

    2-Hydroxybenzoic Acid-d4

     Salicylic Acid-d4 is the deuterium labeled 2-Carboxyphenol. Salicylic Acid-d4 Chemical Structure
  63. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid-d6 Chemical Structure
  64. GC49363 Salicyluric Acid

    2-Hydroxyhippuric Acid, NSC 524135, N-Salicyloylglycine

     A major metabolite of aspirin and salicylic acid Salicyluric Acid Chemical Structure
  65. GC10973 SC 236 COX-2 inhibitor SC 236 Chemical Structure
  66. GC15634 SC 560 COX-1-selective inhibitor SC 560 Chemical Structure
  67. GC17817 SC 58125 COX-2 inhibitor SC 58125 Chemical Structure
  68. GC31960 SC57666

    SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

     SC57666 Chemical Structure
  69. GC31985 SC58451 SC58451 is a potent and selective Cox-2 inhibitor. SC58451 Chemical Structure
  70. GC12013 Sodium salicylate

    NF-κB inhibitor

     Sodium salicylate Chemical Structure
  71. GC60345 Sphondin Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells. Sphondin Chemical Structure
  72. GC64940 Sudoxicam Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam Chemical Structure
  73. GC16716 Sulindac Anti-inflammatory agent;COX inhibitor Sulindac Chemical Structure
  74. GC15059 Sulindac sulfide

    cis-Sulindac sulfide

    COX inhibitor

     Sulindac sulfide Chemical Structure
  75. GC11721 Sulindac sulfone

    Exisulind

     Sulindac sulfone is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Sulindac sulfone Chemical Structure
  76. GC48677 Sulindac-d3

    MK-231-d3

     Sulindac-d3 Chemical Structure
  77. GC31440 Syringaldehyde

    NSC 41153, SM 707, VND 3207

     A polyphenol with diverse biological activities Syringaldehyde Chemical Structure
  78. GC39040 Taraxerol acetate Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC50 values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis. Taraxerol acetate Chemical Structure
  79. GC64025 Tazofelone

    LY 213829

     Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease. Tazofelone Chemical Structure
  80. GC11853 Tenidap

    CP 66,248

     COX/5-LOX inhibitor Tenidap Chemical Structure
  81. GC10006 Tenoxicam

    Ro 12-0068

     antiinflammatory agent Tenoxicam Chemical Structure
  82. GC49386 Tepoxalin

    ORF 20485, RWJ 20485

     A dual inhibitor of COX and 5-LO Tepoxalin Chemical Structure
  83. GC61764 Teriflunomide impurity 3

    4-Amino-N-(4-trifluoromethylphenyl)benzamide

     Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 ?M. Teriflunomide impurity 3 Chemical Structure
  84. GC19353 TFAP

    N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

     TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 uM. TFAP Chemical Structure
  85. GC31826 Thioflosulide (L-745337)

    L-745337

     Thioflosulide (L-745337) (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity. Thioflosulide (L-745337) Chemical Structure
  86. GC45579 Tiaprofenic Acid

    RU 15060, Tiaprofen

       Tiaprofenic Acid Chemical Structure
  87. GC31956 Tilmacoxib (JTE522) Tilmacoxib (JTE522) (JTE522) is a highly selective, time-dependent and irreversible human COX-2 inhibitor with an IC50 of 85 nM in an enzyme assay. Tilmacoxib (JTE522) Chemical Structure
  88. GC31965 Timegadine (SR1368) Timegadine (SR1368), a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. Timegadine (SR1368) Chemical Structure
  89. GC15395 Tolfenamic Acid Non-steroidal anti-inflammatory drug Tolfenamic Acid Chemical Structure
  90. GC45965 Tolfenamic Acid-d4 An internal standard for the quantification of tolfenamic acid Tolfenamic Acid-d4 Chemical Structure
  91. GC61337 Tolmetin Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 ?M and 0.82 ?M human COX-1 and COX-2, respectively. Tolmetin Chemical Structure
  92. GC16428 Tolmetin (sodium salt hydrate) Tolmetin (sodium salt hydrate) is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin (sodium salt hydrate) Chemical Structure
  93. GC13300 Triflusal

    UR 1501

     COX inhibitor Triflusal Chemical Structure
  94. GC13402 Tryptanthrin

    NSC 349447

     inhibitor of Cox-2 and 5-LO Tryptanthrin Chemical Structure
  95. GC14020 Valdecoxib

    SC-65872

     COX-2 inhibitor Valdecoxib Chemical Structure
  96. GC48232 Valdecoxib-d3 An internal standard for the quantification of valdecoxib Valdecoxib-d3 Chemical Structure
  97. GC10335 Valeroyl Salicylate

    2-Valeryloxybenzoic Acid

     selective, irreversible inhibitor of cyclooxygenase-1 (COX-1) Valeroyl Salicylate Chemical Structure
  98. GC61371 Veratric acid Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid Chemical Structure
  99. GC33632 Veratric acid (3,4-Dimethoxybenzoic acid) Veratric acid (3,4-Dimethoxybenzoic acid) Chemical Structure
  100. GC79363 VU0487836 VU0487836 is a selective cyclooxygenase-1 ( COX-1 ) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1. VU0487836 Chemical Structure
  101. GC12391 Xanthohumol Xanthohumol is the main prenylflavonoid in hops that inhibits diacylglycerol acyltransferase (DGAT) with IC50 value of 50.3μM. Xanthohumol Chemical Structure

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