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Catalog No.GC14730

Veratridine Chemical Structure

Voltage-gated Na+ channel opener

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Cell experiment [1]:

Cell lines

HCT-116 colon cancer cells (expressing GFP-UBXN2A)

Preparation method

The solubility of this compound in DMSO is >10mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

20 and 40 μM, 24 hours


Veratridine is the main UBXN2A enhancer, increased UBXN2A protein levels in a dose-dependent manner.

Animal experiment [2]:

Animal models

C57Bl/6N mice( HCT-116 cells expressing GFP-UBXN2A were injected into 6 to 8 week old nude female mice)

Dosage form

Intraperitoneal injection (IP), 0.125 mg/kg for 28 days


Veratridine (VTD) was sufficient to induce UBXN2A protein levels, resulting in colon cancer cell death in UBXN2A- and mot-2-dependent manners.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1]. Abdullah A, Sane S, Branick KA,et al.A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. Oncotarget. 2015 Sep 15;6(27):23561-81.


Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

[1]. Purification, solubility and pKa of veratridine.
      McKinney et al.
     Anal.Biochem., 1986;153:33
[2]. Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+      oscillations induced by veratridine.
     Maroto et al.
     Eur.J.Pharmacol., 1994;270:331
[3]. Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation:      implication for epilepsy.
     Fekete et al.
     J.Neurochem., 2009;111:745

Chemical Properties

Cas No. 71-62-5 SDF
Synonyms N/A
Chemical Name (3S,4S,4aS,6aS,6bS,8R,8aS,9S,9aS,12S,15aS,15bR,16aR,16bR)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-1H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl 3,4-dimethoxybenzoate
Canonical SMILES O[C@@]([C@@]1([C@H](CN2[C@H]3CC[C@H](C)C2)[C@]4([C@@]3(C)O)O)O)(C[C@H]4O)[C@H]5[C@@]([C@@](CC[C@@H]6OC(C(C=C7OC)=CC=C7OC)=O)(C)[C@@H]8CC5)(C1)O[C@@]86O
Formula C36H51NO11 M.Wt 673.79
Solubility <33.69mg/ml in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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