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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Pim

Pim

Pim protein kinases are a family of serine/threonine kinases consisting of three members of Ca2+/calmodulin-dependent protein kinases, including PIM1, PIM2 and PIM3, that are responsible for cell cycle regulation and antiapoptotic activity as well as homing and migration of receptor tyrosine kinases mediated through the JAK/STAT pathway. All three pim protein kinases share high homology at the amino acid level and hence exhibit greatly overlapping functions, in which 71% and 61% identical amino acids have been found between PIM1/PIM3 and between PIM1/PIM2 respectively. PIM1 comprises two isoforms of 34 and 44 kDa respectively; while PIM2 comprises three isoforms of 34, 37 and 40 kDa respectively. However, PIM3 comprises only one protein.

Products for  Pim

  1. Cat.No. Product Name Information
  2. GC34964 (1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. (1S,3R,5R)-PIM447 dihydrochloride Chemical Structure
  3. GC12660 AZD1208 A pan-Pim kinase inhibitor AZD1208 Chemical Structure
  4. GC35447 AZD1208 hydrochloride AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor. AZD1208 hydrochloride Chemical Structure
  5. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8 CK2/ERK8-IN-1 Chemical Structure
  6. GC13056 CX-6258 A pan-Pim kinase inhibitor CX-6258 Chemical Structure
  7. GC19747 CX-6258 HCl CX-6258 HCl is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively. CX-6258 HCl Chemical Structure
  8. GC35762 CX-6258 hydrochloride hydrate CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively. CX-6258 hydrochloride hydrate Chemical Structure
  9. GC32958 GDC-0339 GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 Chemical Structure
  10. GC33253 GNE-955 GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. GNE-955 Chemical Structure
  11. GC12359 Hispidulin Partial positive allosteric modulator at the benzodiazepine receptor Hispidulin Chemical Structure
  12. GC13154 LKB1(AAK1 dual inhibitor) LKB1(AAK1 dual inhibitor) Chemical Structure
  13. GC34138 M-110 M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM. M-110 Chemical Structure
  14. GC49412 NSC 756093 An inhibitor of the GBP1-Pim-1 protein-protein interaction NSC 756093 Chemical Structure
  15. GC19419 PIM inhibitor 1 phosphate Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. PIM inhibitor 1 phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines. PIM inhibitor 1 phosphate Chemical Structure
  16. GC13558 PIM-1 Inhibitor 2 A potent PIM-1 kinase inhibitor PIM-1 Inhibitor 2 Chemical Structure
  17. GC36918 PIM-447 dihydrochloride A pan-Pim kinase inhibitor PIM-447 dihydrochloride Chemical Structure
  18. GC65278 PIM1-IN-1 PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity. PIM1-IN-1 Chemical Structure
  19. GC19398 PIM447

    PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.

     PIM447 Chemical Structure
  20. GC65201 Quercetagetin Quercetagetin (6-Hydroxyquercetin) is a flavonoid. Quercetagetin Chemical Structure
  21. GC64774 SEL24-B489 SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively. SEL24-B489 Chemical Structure
  22. GC16497 SGI-1776 free base A potent inhibitor of Pim kinases SGI-1776 free base Chemical Structure
  23. GC37651 SMI-16a A Pim-1 kinase inhibitor SMI-16a Chemical Structure
  24. GC11104 SMI-4a A Pim kinase inhibitor SMI-4a Chemical Structure
  25. GC17178 TCS PIM-1 1 A Pim-1 kinase inhibitor TCS PIM-1 1 Chemical Structure
  26. GC11990 TCS-PIM-1-4a Pim inhibitor TCS-PIM-1-4a Chemical Structure
  27. GC19361 TP-3654 TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. TP-3654 Chemical Structure

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