Dehydrogenase
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
Products for Dehydrogenase
- Cat.No. Product Name Information
- GC10462 6-Aminonicotinamide 6-phosphogluconate dehydrogenase inhibitor
- GC13262 A-771726 dihydroorotate dehydrogenase inhibitor
- GC15601 AG-120 AG-120 (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo.
- GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
- GC13147 AG-221 (Enasidenib) AG-221 (Enasidenib) is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively.
- GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations
- GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2
-
GC16597
Alda 1
ALDH2 activator
- GC15738 BVT 2733 BVT 2733 is a novel, small-molecule, nonsteroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 of 96 nM (mice).
- GC13336 CBR-5884 selective inhibitor of PHGDH
- GC13611 CGP 3466B maleate CGP 3466B maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
- GC14921 CPI-613 An inhibitor of α-ketoglutarate dehydrogenase
- GC10902 CVT 10216 reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2)
- GC25389 Ethyl potassium malonate Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.
- GC17914 Fomepizole competitive inhibitor of the enzyme alcohol dehydrogenase
- GC16816 Galloflavin human lactate dehydrogenase (LDH) inhibitor
- GC17467 Gimeracil A DYPD inhibitor
-
GC13464
GSK 2837808A
GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 2.
- GC15547 Inosine-5'-monophosphate (sodium salt hydrate) substrate of IMP dehydrogenase (IMPDH)
- GC11149 L-a-Hydroxyglutaric acid disodium salt L-a-Hydroxyglutaric acid disodium salt is an epigenetic modifier and putative oncometabolite in renal cancer. L-a-Hydroxyglutaric acid disodium salt can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
- GC13670 Methylmalonate Methylmalonate (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer.
- GC14415 ML390 human DHODH inhibitor
- GC13614 Mycophenolate Mofetil A prodrug form of mycophenolic acid
- GC16860 NCT-502 inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)
-
GC15943
NCT-503
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 ?M
- GC17293 PHGDH-inactive inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503
- GC13776 Piericidin A mitochondrial complex I inhibitor
- GC50508 PKUMDL WQ 2101 Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
- GC50509 PKUMDL WQ 2201 Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
- GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase
- GC15266 Qc 1 threonine dehydrogenase (TDH) inhibitor
- GC16951 Stiripentol An LDH inhibitor
- GC12204 STK393606 competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH
- GC13760 TC HSD 21 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor
- GC14783 Trilostane A 3β-hydroxysteroid dehydrogenase inhibitor
- GC14851 Vidofludimus DHODH inhibitor
- GC10438 WIN 18446 inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)