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Memantine hydrochloride (Synonyms: Akatinol, Axura, Ebix, Namenda, NSC 102290, SUN Y7017)

Catalog No.GC10198

NMDA receptor antagonist

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Memantine hydrochloride Chemical Structure

Cas No.: 41100-52-1

Size Price Stock Qty
10mM (in 1mL DMSO)
$35.00
In stock
500mg
$28.00
In stock
1g
$39.00
In stock
5g
$69.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93μM, 0.82μM and 0.47μM for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics [1].

Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer’s disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine [2].

References:
[1] Bresink I, Benke T A, Collett V J, et al. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. British journal of pharmacology, 1996, 119(2): 195-204.
[2] Danysz W, Parsons C G. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections. British journal of pharmacology, 2012, 167(2): 324-352.

Chemical Properties

Cas No. 41100-52-1 SDF
Synonyms Akatinol, Axura, Ebix, Namenda, NSC 102290, SUN Y7017
Chemical Name 3,5-dimethyladamantan-1-amine;hydrochloride
Canonical SMILES CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
Formula C12H22ClN M.Wt 215.76
Solubility ≥ 12.6mg/mL in DMSO; ≥20 mg/mL in Water Storage Store at RT
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.6348 mL 23.1739 mL 46.3478 mL
5 mM 0.927 mL 4.6348 mL 9.2696 mL
10 mM 0.4635 mL 2.3174 mL 4.6348 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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