5-HT Receptor
5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.
Products for 5-HT Receptor
- Cat.No. Product Name Information
- GC11338 Org 37684 5-HT2 receptors agonist
- GC38828 Org-12962 Org-12962 is a potent, selective and orally active 5-HT2C?receptor agonist with a pEC50?value of 7.01.
- GC61401 Oxatomide Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity.
- GC60293 p-MPPI hydrochloride p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors.
- GC61167 Paliperidone palmitate Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone.
- GC36844 Palonosetron Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
- GC17917 Palonosetron HCl Palonosetron HCl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
- GC31022 Pancopride (LAS 30451) Pancopride (LAS 30451) is a new potent and selective 5-HT3 receptor antagonist.
- GC31069 Pardoprunox (SLV-308) Pardoprunox (SLV-308) (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively.
- GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride) Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively.
- GC18102 Paroxetine maleate 5-HT uptake inhibitor
- GC31767 Peptide 401 Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
- GC39237 Perospirone Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM).
- GC12293 Perphenazine dopamine antagonist
- GC36875 Perphenazine D8 Dihydrochloride Perphenazine D8 Dihydrochloride is the deuterium labeled Perphenazine, which is a typical antipsychotic drug(5-HT, Dopamine receptor ligand).
- GC50668 PF 04479745 PF 04479745 is a potent and selective 5-HT2C receptor agonist (EC50: 10 nM, ki: 15 nM). PF 04479745 can be used in the research of cardiovascular disease like hypertension.
- GC45791 PF-04995274 A partial 5-HT4 agonist
- GC30953 Phenylbiguanide (N-Phenylbiguanide) Phenylbiguanide (N-Phenylbiguanide) is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
- GC19294 Piboserod Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
- GC36912 Piboserod hydrochloride Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist.
-
GC11844
Pimavanserin
5-HT2A inverse agonist
- GC36919 Pimavanserin tartrate Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.
- GC30999 Pimethixene (Pimetixene) Pimethixene (Pimetixene) is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
- GC65296 Pimethixene maleate Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
-
GC17734
Pindolol
β-adrenoceptor antagonist with partial agonist activity
- GC36924 Pipamperone Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).
- GC25756 Pirenperone Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
- GC13053 Pizotifen Highly selective 5-HT receptor blocking agent
- GC13478 Pizotifen Malate 5-HT receptor antagonist
- GC15011 PNU 109291 5-HT1D receptor agonist
- GC17854 PNU 142633 5-HT1D receptor agonist
- GC17714 PNU 22394 hydrochloride 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist
- GC11714 Prucalopride 5-HT4A and 5-HT4B receptor agonist
- GC13291 Prucalopride Succinat Prucalopride Succinat is a selective, high affinity 5-HT4 receptor agonist with pKi of 8.6/8.1 for 5-HT4a/4b.
- GC50564 PRX 07034 PRX 07034 is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM.
- GC10450 PRX-08066 5-HT2BR antagonist
- GC16788 PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective
- GC32595 PRX933 hydrochloride (GW876167 hydrochloride) PRX933 hydrochloride (GW876167 hydrochloride) is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1.
- GC17857 PU 02 negative allosteric modulator of 5-HT3 receptors
- GN10680 Puerarin
- GC31393 Pumosetrag Hydrochloride (MKC-733) Pumosetrag Hydrochloride (MKC-733) (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
- GC14167 Quetiapine
- GC37055 Quetiapine D4 fumarate Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate.
- GC39724 Quetiapine D4 hemifumarate Quetiapine D4 hemifumarate is the deuterium labeled Quetiapine hemifumarate.
- GC16891 Quetiapine Fumarate Quetiapine Fumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor.
- GC16506 Quipazine dimaleate 5-HT3 receptor agonist
- GC13369 R 1485 dihydrochloride 5-HT6 antagonist,selective and high affinity
- GC14583 R 59-022 Diacylglycerol (DAG) kinase inhibitor
- GC17706 R-96544 hydrochloride 5-HT2 receptor antagonist
- GC15639 Ramosetron Hydrochloride 5-HT3 receptor antagonist
- GC63169 Relenopride hydrochloride Relenopride (YKP10811) hydrochloride is a specific and selective 5-HT4 receptor agonist (Ki=4.96 nM).
- GC67923 Renzapride
- GC64423 Repinotan hydrochloride Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors.
- GC30681 Revexepride Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.
- GC34158 RG-12915 RG-12915 is a selective 5-HT3 antagonist, with IC50 value of 0.16 nM.
-
GC12986
Risperidone
SR-2A inhibitor
- GC37539 Risperidone hydrochloride Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
- GC37540 Risperidone mesylate Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
- GC13883 Ritanserin long-acting 5-HT2 receptor antagonist
- GC10460 Rizatriptan Benzoate 5-HT Receptor agonist
- GC17260 Ro 04-6790 5-HT6 receptor antagonist
- GC15135 Ro 60-0175 fumarate 5-HT2 receptor agonist
- GC64606 Ro60-0175 Ro60-0175 is a potent and selective agonist of 5-HT2C receptor.
- GC63842 Rodatristat Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.
- GC62458 Rodatristat ethyl Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency.
- GC30206 Roluperidone (CYR-101) Roluperidone (CYR-101) (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).
- GC10614 Rotigotine A non-selective dopamine receptor agonist
- GC16017 Rotigotine hydrochloride A non-selective dopamine receptor agonist
- GC14657 Rotundine Dopamine D1 receptor antagonist,potent and selective
- GC50007 RS 102221 hydrochloride Selective 5-HT2C antagonist
- GC11729 RS 127445 A 5-HT2B receptor antagonist
- GC10670 RS 127445 HCl 5-HT2B receptor antagonist,high affinity
- GC50033 RS 127445 hydrochloride High affinity and selective 5-HT2B antagonist
-
GC15979
RS 16566 dihydrochloride
ligand for the (R)-zacopride binding site
- GC16861 RS 23597-190 hydrochloride 5-HT4 receptor antagonist
- GC14625 RS 39604 hydrochloride RS 39604 hydrochloride is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes.
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GC15137
RS 56812 hydrochloride
5-HT3 partial agonist
-
GC12340
RS 67333 hydrochloride
potent and highly selective 5-HT4 partial agonist
- GC14696 RS 67506 hydrochloride potent and selective 5-HT4 partial agonist
- GC37569 RU 24969 RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain.
- GC50006 RU 24969 hemisuccinate 5-HT1A and 5-HT1B agonist
- GC31827 Rupatadine (UR-12592) Rupatadine (UR-12592) (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively.
- GC11033 Rupatadine Fumarate Inhibitor of PAF and histamine (H1) receptor
- GC18013 S 14506 hydrochloride 5-HT1A receptor full agonist
- GC10535 S 32212 hydrochloride inverse agonist of 5-HT2C receptors
- GC64530 Sarizotan Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist.
- GC16202 Sarpogrelate hydrochloride 5-HT2A receptor inhibitor
- GC25898 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
- GC14052 SB 200646 hydrochloride 5-HT2C/2B receptor antagonist
- GC16439 SB 203186 hydrochloride Potent 5-HT4 receptor antagonist
- GC10401 SB 204070 Potent and selective 5-HT4 receptor antagonist
- GC12803 SB 204741 5-HT2B receptor antagonist
-
GC10310
SB 206553 hydrochloride
5-HT2B/5-HT2C receptor antagonist
- GC50014 SB 215505 5-HT2B/2C antagonist
- GC15551 SB 216641 hydrochloride h5-HT1B antagonist
- GC16556 SB 221284 5-HT2C/2B receptor antagonist
- GC13438 SB 224289 hydrochloride 5-HT1B receptor antagonist
- GC14347 SB 228357 5-HT2C/2B receptor antagonist
- GC14392 SB 242084 5-HT2C receptor antagonist
- GC61268 SB 243213 SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor.