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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Targets for  Endogenous Metabolite

Products for  Endogenous Metabolite

  1. Cat.No. Product Name Information
  2. GC13571 2-Deoxyuridine A pyrimidine nucleoside 2-Deoxyuridine Chemical Structure
  3. GC60472 2-Ethylpyrazine 2-Ethylpyrazine Chemical Structure
  4. GC33645 2-Guanidinoacetic acid 2-Guanidinoacetic acid (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. 2-Guanidinoacetic acid Chemical Structure
  5. GC31544 2-Hydroxy-2-methylbutanoic acid 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutanoic acid Chemical Structure
  6. GC38281 2-Hydroxy-2-phenylacetic acid 2-Hydroxy-2-phenylacetic acid ((±)-2-Hydroxy-2-phenylacetic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. 2-Hydroxy-2-phenylacetic acid Chemical Structure
  7. GC31222 2-Hydroxy-3-methylbutanoic acid 2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive drug. 2-Hydroxy-3-methylbutanoic acid Chemical Structure
  8. GC60475 2-Hydroxy-4-methylbenzaldehyde 2-Hydroxy-4-methylbenzaldehyde is an endogenous metabolite. 2-Hydroxy-4-methylbenzaldehyde Chemical Structure
  9. GC30612 2-Hydroxyadipic acid 2-Hydroxyadipic acid is an organic acid, formed by the reduction of 2-ketoadipic acid. 2-Hydroxyadipic acid Chemical Structure
  10. GC38190 2-Hydroxyhexanoic acid 2-Hydroxyhexanoic acid is an endogenous metabolite. 2-Hydroxyhexanoic acid Chemical Structure
  11. GC19715 2-hydroxyisobutyrate 2-hydroxyisobutyrate is an endogenous metabolite. 2-hydroxyisobutyrate Chemical Structure
  12. GC68519 2-Hydroxyisobutyric acid-d6

    2-Hydroxyisobutyric acid-d6 is the deuterated form of 2-Hydroxyisobutyric acid. 2-Hydroxyisobutyric acid is an endogenous metabolic product.

     2-Hydroxyisobutyric acid-d6 Chemical Structure
  13. GC60476 2-hydroxymethyl benzoic acid 2-Hydroxymethyl benzoic acid is an endogenous metabolite. 2-hydroxymethyl benzoic acid Chemical Structure
  14. GC33742 2-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid is a potential biomarker for the food products, and found to be associated with phenylketonuria (PKU). 2-Hydroxyphenylacetic acid Chemical Structure
  15. GC30136 2-Ketoglutaric acid An intermediate in the citric acid cycle 2-Ketoglutaric acid Chemical Structure
  16. GC39761 2-Mercaptobenzothiazole 2-Mercaptobenzothiazole Chemical Structure
  17. GC34179 2-Methoxybenzoic acid (NSC 3778) 2-Methoxybenzoic acid (NSC 3778) (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine. 2-Methoxybenzoic acid (NSC 3778) Chemical Structure
  18. GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me) is a HIF-1α inhibitor that inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can trigger p53-induced apoptosis and has potential antitumor activity.. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  19. GC33810 2-Methoxyestrone An active metabolite of estrone 2-Methoxyestrone Chemical Structure
  20. GC39776 2-Methylacetophenone 2-Methylacetophenone Chemical Structure
  21. GC60477 2-Methylbenzaldehyde 2-Methylbenzaldehyde is an endogenous metabolite. 2-Methylbenzaldehyde Chemical Structure
  22. GC60478 2-Methylbenzoxazole 2-Methylbenzoxazole Chemical Structure
  23. GC60479 2-Methylcitric acid An endogenous tricarboxylic acid 2-Methylcitric acid Chemical Structure
  24. GC60480 2-Methylcitric acid trisodium 2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium Chemical Structure
  25. GC62779 2-Methylcyclohexanone 2-Methylcyclohexanone Chemical Structure
  26. GC30671 2-Methylpentanedioic acid

    2-Methylpentanedioic acid is a metabolite of succinic acid, a citric acid cycle intermediate.

     2-Methylpentanedioic acid Chemical Structure
  27. GC31435 2-Methylsuccinic acid

    2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.

     2-Methylsuccinic acid Chemical Structure
  28. GC60481 2-Methylvaleric acid 2-Methylvaleric acid (2-Methylpentanoic acid) is a short-chain fatty acid isolated from Campomanesia adamantium and dairy products. 2-Methylvaleric acid Chemical Structure
  29. GC30720 2-Naphthol 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2). 2-Naphthol Chemical Structure
  30. GC39845 2-Naphthoxyacetic acid 2-Naphthoxyacetic acid is an endogenous metabolite. 2-Naphthoxyacetic acid Chemical Structure
  31. GC39527 2-O-Methylcytosine 2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase. 2-O-Methylcytosine Chemical Structure
  32. GC30622 2-Oxo-3-phenylpropanoic acid 2-Oxo-3-phenylpropanoic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. 2-Oxo-3-phenylpropanoic acid Chemical Structure
  33. GC30629 2-Oxobutanoic acid

    2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

     2-Oxobutanoic acid Chemical Structure
  34. GC38276 2-Oxosuccinic acid 2-Oxosuccinic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. 2-Oxosuccinic acid Chemical Structure
  35. GC30713 2-Oxovaleric acid

    2-Oxovaleric acid is a keto acid that is found in human blood.

     2-Oxovaleric acid Chemical Structure
  36. GC60018 2-Phenylacetaldehyde 2-Phenylacetaldehyde is an endogenous metabolite. 2-Phenylacetaldehyde Chemical Structure
  37. GC60483 2-Phenylacetamide 2-Phenylacetamide Chemical Structure
  38. GC62784 2-Phenylbutanoic acid 2-Phenylbutanoic acid is an endogenous metabolite. 2-Phenylbutanoic acid Chemical Structure
  39. GC60485 2-Phenylglycine 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period. 2-Phenylglycine Chemical Structure
  40. GC31611 2-Phenylpropionic acid 2-Phenylpropionic acid is an intermediate in alpha-Methylstyrene metabolism. 2-Phenylpropionic acid Chemical Structure
  41. GC35095 2-Phospho-L-ascorbic acid trisodium salt 2-Phospho-L-ascorbic acid trisodium salt (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. 2-Phospho-L-ascorbic acid trisodium salt Chemical Structure
  42. GC60486 2-Piperidone 2-Piperidone is an endogenous metabolite. 2-Piperidone Chemical Structure
  43. GC19539 2-Pyrrolidinone

    2-Pyrrolidinone

     2-Pyrrolidinone Chemical Structure
  44. GC60487 2-Thiophenecarboxaldehyde 2-Thiophenecarboxaldehyde Chemical Structure
  45. GC35075 20-HETE A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications 20-HETE Chemical Structure
  46. GC33798 21-Hydroxypregnenolone 21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis. 21-Hydroxypregnenolone Chemical Structure
  47. GC62767 23,25-Dihydroxy-24-oxovitamin D3 23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 Chemical Structure
  48. GC17566 24, 25-Dihydroxy VD3 24, 25-Dihydroxy VD3 Chemical Structure
  49. GC13887 25(R)-27-hydroxy Cholesterol 25(R)-27-hydroxy Cholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. 25(R)-27-hydroxy Cholesterol Chemical Structure
  50. GC35081 25,26-Dihydroxyvitamin D3 25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. 25,26-Dihydroxyvitamin D3 Chemical Structure
  51. GC33860 25-Hydroxycholesterol

    25-hydroxycholesterol is a metabolite of cholesterol that can selectively inhibit the production of IgA by B cells, with an EC50 of approximately 65 nM.

     25-Hydroxycholesterol Chemical Structure
  52. GC64985 3'-O-Methylguanosine 3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator. 3'-O-Methylguanosine Chemical Structure
  53. GC60023 3'-Deoxyuridine-5'-triphosphate 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate Chemical Structure
  54. GC61862 3'-Deoxyuridine-5'-triphosphate trisodium 3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium Chemical Structure
  55. GC42201 3,3'-Diiodo-L-thyronine 3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3'-T2. 3,3'-Diiodo-L-thyronine Chemical Structure
  56. GC60491 3,3-Dimethylglutaric acid 3,3-Dimethylglutaric acid, a member of methyl-branched fatty acids, is a endogenous metabolite occasionally found in human urine. 3,3-Dimethylglutaric acid Chemical Structure
  57. GC33703 3,4,5-Trimethoxycinnamic acid 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid Chemical Structure
  58. GC33649 3,4-Dihydroxybenzeneacetic acid A dopamine metabolite 3,4-Dihydroxybenzeneacetic acid Chemical Structure
  59. GC30146 3,4-Dihydroxymandelic acid 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine. 3,4-Dihydroxymandelic acid Chemical Structure
  60. GC39777 3,4-Dimethoxyphenethylamine 3,4-Dimethoxyphenethylamine Chemical Structure
  61. GC33615 3,4-Dimethoxyphenylacetic acid 3,4-Dimethoxyphenylacetic acid is a building block in the chemical synthesis. 3,4-Dimethoxyphenylacetic acid Chemical Structure
  62. GC60497 3,5-Dihydroxyacetophenone 3,5-Dihydroxyacetophenone is an endogenous metabolite. 3,5-Dihydroxyacetophenone Chemical Structure
  63. GC33817 3,5-Dihydroxybenzoic acid 3,5-Dihydroxybenzoic acid Chemical Structure
  64. GC61716 3,5-Dimethylbenzaldehyde 3,5-Dimethylbenzaldehyde is a building block in the chemical synthesis. 3,5-Dimethylbenzaldehyde Chemical Structure
  65. GC62789 3-(2-Hydroxyphenyl)propanoic acid 3-(2-Hydroxyphenyl)propanoic acid is an endogenous metabolite. 3-(2-Hydroxyphenyl)propanoic acid Chemical Structure
  66. GC33618 3-(3,4,5-Trimethoxyphenyl)propanoic acid 3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid Chemical Structure
  67. GC60488 3-(3-Hydroxyphenyl)propionic acid 3-(3-Hydroxyphenyl)propionic acid is a flavonoid metabolite formed by human microflora. 3-(3-Hydroxyphenyl)propionic acid Chemical Structure
  68. GC31625 3-(3-Methoxyphenyl)propionic acid 3-(3-Methoxyphenyl)propionic acid is an organic acid, naturally occurring human metabolite and excreted in human urine. 3-(3-Methoxyphenyl)propionic acid Chemical Structure
  69. GC32943 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) is an intermediate in the methionine metabolism. 3-(Methylthio)propionic acid (3-Methylsulfanylpropionic acid) Chemical Structure
  70. GC31569 3-Amino-2-methylpropanoic acid 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. 3-Amino-2-methylpropanoic acid Chemical Structure
  71. GC62793 3-Amino-2-oxazolidinone 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone. 3-Amino-2-oxazolidinone Chemical Structure
  72. GC39688 3-Amino-2-piperidinone 3-aminopiperidine-2-one is a metabolite from all living organisms. 3-Amino-2-piperidinone Chemical Structure
  73. GC38293 3-Amino-4-hydroxybenzoic acid 3-Amino-4-hydroxybenzoic acid is an endogenous metabolite. 3-Amino-4-hydroxybenzoic acid Chemical Structure
  74. GC30719 3-Amino-4-methylpentanoic acid

    3-Amino-4-methylpentanoic acid is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase.

     3-Amino-4-methylpentanoic acid Chemical Structure
  75. GC33631 3-Chloro-L-tyrosine 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. 3-Chloro-L-tyrosine Chemical Structure
  76. GC40743 3-deoxy Galactosone 3-deoxy Galactosone is a 1,2-dicarbonyl compound originating from the degradation of galactose. 3-deoxy Galactosone Chemical Structure
  77. GC38257 3-Ethoxy-3-oxopropanoic acid 3-Ethoxy-3-oxopropanoic acid is an endogenous metabolite. 3-Ethoxy-3-oxopropanoic acid Chemical Structure
  78. GC38368 3-Furanoic acid 3-Furanoic acid is an endogenous metabolite. 3-Furanoic acid Chemical Structure
  79. GC13377 3-hydroxy Anthranilic Acid co-antioxidant 3-hydroxy Anthranilic Acid Chemical Structure
  80. GC60501 3-Hydroxy-4-aminopyridine 3-Hydroxy-4-aminopyridine Chemical Structure
  81. GC38669 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid Chemical Structure
  82. GC30616 3-Hydroxybutyric acid

    3-Hydroxybutyric acid is a class of histone deacetylase (HDAC) inhibitors with IC50s of 5.3, 2.4 and 4.5 mM for HDAC1, HDAC3 and HDAC4 inhibition respectively.

     3-Hydroxybutyric acid Chemical Structure
  83. GC60502 3-Hydroxybutyric acid sodium 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium Chemical Structure
  84. GC33383 3-Hydroxycapric acid 3-Hydroxycapric acid is an inhibitor for mitotic progression. 3-Hydroxycapric acid Chemical Structure
  85. GC30642 3-Hydroxydodecanoic acid

    A hydroxy fatty acid

     3-Hydroxydodecanoic acid Chemical Structure
  86. GC41477 3-Hydroxyglutaric Acid Glutaryl-CoA dehydrogenase (GCDH) is a mitochondrial matrix protein that catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolic pathways of lysine, hydroxylysine, and tryptophan metabolism. 3-Hydroxyglutaric Acid Chemical Structure
  87. GC66424 3-Hydroxyglutaric acid-d5 3-Hydroxyglutaric acid-d5 is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative. 3-Hydroxyglutaric acid-d5 Chemical Structure
  88. GC30603 3-Hydroxyhippuric acid 3-Hydroxyhippuric acid is an acyl glycine. 3-Hydroxyhippuric acid Chemical Structure
  89. GC30660 3-Hydroxyisovaleric acid An active metabolite of L-leucine 3-Hydroxyisovaleric acid Chemical Structure
  90. GC30638 3-Hydroxymandelic Acid 3-Hydroxymandelic Acid, a metabolite of Phenylephrine, Phenylephrine is a α-receptor agonist. 3-Hydroxymandelic Acid Chemical Structure
  91. GC38269 3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid Chemical Structure
  92. GC14549 3-Hydroxyphenylacetic acid NULL 3-Hydroxyphenylacetic acid Chemical Structure
  93. GC30636 3-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI)) 3-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI)) is a picolinic acid derivative, and belongs to the pyridine family. 3-Hydroxypicolinic acid (Picolinic acid, 3-hydroxy- (6CI,7CI,8CI)) Chemical Structure
  94. GC30729 3-Hydroxyvaleric acid

    3-Hydroxyvaleric acid is a 5-carbon ketone body.

     3-Hydroxyvaleric acid Chemical Structure
  95. GC33436 3-Indoleacetic acid (Indole-3-acetic acid) 3-Indoleacetic acid (Indole-3-acetic acid) (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. 3-Indoleacetic acid (Indole-3-acetic acid) Chemical Structure
  96. GC39778 3-Indoleacetonitrile 3-Indoleacetonitrile is an endogenous metabolite. 3-Indoleacetonitrile Chemical Structure
  97. GC31290 3-Indolepropionic acid A bacterial metabolite with antioxidant and neuroprotective activities 3-Indolepropionic acid Chemical Structure
  98. GC33653 3-Methoxybenzoic acid (3-Anisic acid) 3-Methoxybenzoic acid (3-Anisic acid) can be used in the synthesis of 3-methoxybenzoates of europium (III) and gadolinium (III). 3-Methoxybenzoic acid (3-Anisic acid) Chemical Structure
  99. GC33739 3-Methoxytyramine (3-O-methyl Dopamine) 3-Methoxytyramine (3-O-methyl Dopamine), a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator. 3-Methoxytyramine (3-O-methyl Dopamine) Chemical Structure
  100. GC33738 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) Chemical Structure
  101. GC39690 3-Methyl-2-buten-1-ol 3-Methyl-2-buten-1-ol is an endogenous metabolite. 3-Methyl-2-buten-1-ol Chemical Structure

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