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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Targets for  Endogenous Metabolite

Products for  Endogenous Metabolite

  1. Cat.No. Product Name Information
  2. GC39846 3-Methyl-2-cyclopenten-1-one 3-Methyl-2-cyclopenten-1-one Chemical Structure
  3. GC19716 3-methyl-2-oxobutyrate 3-methyl-2-oxobutyrate is a precursor of pantothenic acid in Escherichia coli. 3-methyl-2-oxobutyrate Chemical Structure
  4. GC30593 3-Methyl-2-oxovaleric acid 3-Methyl-2-oxovaleric acid is a neurotoxin, an acidogen, and a metabotoxin, and also an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. 3-Methyl-2-oxovaleric acid Chemical Structure
  5. GC31535 3-Methyl-L-histidine An amino acid 3-Methyl-L-histidine Chemical Structure
  6. GC10710 3-Methyladenine

    3-Methyladenine is a classic autophagy inhibitor.

     3-Methyladenine Chemical Structure
  7. GC31546 3-Methyladipic acid 3-Methyladipic acid is the final metabolite in the ω-oxidation pathway. 3-Methyladipic acid Chemical Structure
  8. GC38360 3-Methylbut-2-enoic acid 3-Methylbut-2-enoic acid is an endogenous metabolite. 3-Methylbut-2-enoic acid Chemical Structure
  9. GC31595 3-Methylbutanoic acid 3-Methylbutanoic acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human. 3-Methylbutanoic acid Chemical Structure
  10. GC18628 3-Methylcrotonyl Glycine

    3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities.

     3-Methylcrotonyl Glycine Chemical Structure
  11. GC16812 3-Methylglutaric acid A metabolite of L-leucine 3-Methylglutaric acid Chemical Structure
  12. GC62795 3-Methylhistamine dihydrochloride 3-Methylhistamine dihydrochloride is a degradation product of histamine. 3-Methylhistamine dihydrochloride Chemical Structure
  13. GC38297 3-Methylindolin-2-one 3-Methylindolin-2-one Chemical Structure
  14. GC33525 3-Methyluridine 3-Methyluridine (N3-Methyluridine) is a modified RNA nucleoside. 3-Methyluridine Chemical Structure
  15. GC62796 3-Methylvaleric Acid 3-Methylvaleric Acid is a flavouring ingredient. 3-Methylvaleric Acid Chemical Structure
  16. GC30635 3-Methylxanthine A cGMP PDE inhibitor and metabolite of theophylline and caffeine 3-Methylxanthine Chemical Structure
  17. GC60505 3-O-Methyldopa 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa Chemical Structure
  18. GC60506 3-O-Methyldopa D3 3-O-Methyldopa D3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa D3 Chemical Structure
  19. GC62797 3-Oxo-4,6-choladien-24-oic acid 3-Oxo-4,6-choladien-24-oic acid is an endogenous metabolite. 3-Oxo-4,6-choladien-24-oic acid Chemical Structure
  20. GC64220 3-Oxo-7-hydroxychol-4-enoic acid 3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid Chemical Structure
  21. GC45339 3-Oxocholic Acid A secondary bile acid 3-Oxocholic Acid Chemical Structure
  22. GC30353 3-Oxopentanedioic acid 3-Oxopentanedioic acid is a simple dicarboxylic acid, which is well-known to be used in the tropinone synthesis. 3-Oxopentanedioic acid Chemical Structure
  23. GC62798 3-Phenylbutyric acid 3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid Chemical Structure
  24. GC33604 3-Pyridineacetic acid 3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids). 3-Pyridineacetic acid Chemical Structure
  25. GC31553 3b-Hydroxy-5-cholenoic acid A bile acid 3b-Hydroxy-5-cholenoic acid Chemical Structure
  26. GC33976 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity. 4',7-Dimethoxyisoflavone (Dimethoxydaidzein) Chemical Structure
  27. GC41003 4'-O-methyl Quercetin 4'-O-methyl Quercetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. 4'-O-methyl Quercetin Chemical Structure
  28. GC62800 4,4’-Disulfanediylbis(2-aminobutanoic acid) 4,4’-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite. 4,4’-Disulfanediylbis(2-aminobutanoic acid) Chemical Structure
  29. GC60510 4,4-Dimethoxy-2-butanone 4,4-Dimethoxy-2-butanone is an endogenous metabolite. 4,4-Dimethoxy-2-butanone Chemical Structure
  30. GC32483 4,6-Dioxoheptanoic acid 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis. 4,6-Dioxoheptanoic acid Chemical Structure
  31. GC31640 4-(1,2-Dihydroxyethyl)benzene-1,2-diol 4-(1,2-Dihydroxyethyl)benzene-1,2-diol, a normal norepinephrine metabolite, is found to be associated with Menkes syndrome. 4-(1,2-Dihydroxyethyl)benzene-1,2-diol Chemical Structure
  32. GC33504 4-Acetamidobutanoic acid (N-acetyl GABA) 4-Acetamidobutanoic acid (N-acetyl GABA) (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities. 4-Acetamidobutanoic acid (N-acetyl GABA) Chemical Structure
  33. GC66484 4-Amino-L-phenylalanine hydrochloride 4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) hydrochloride is an endogenous metabolite. 4-Amino-L-phenylalanine hydrochloride Chemical Structure
  34. GC10996 4-Aminobenzoic acid NULL 4-Aminobenzoic acid Chemical Structure
  35. GC16443 4-Aminohippuric Acid typical substrate of organic anion transport systems 4-Aminohippuric Acid Chemical Structure
  36. GC39473 4-Bromo-3-hydroxybenzoic acid 4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid Chemical Structure
  37. GC60512 4-Carboxypyrazole 4-Carboxypyrazole is an endogenous metabolite. 4-Carboxypyrazole Chemical Structure
  38. GC60514 4-Ethoxyphenol 4-Ethoxyphenol is an endogenous metabolite. 4-Ethoxyphenol Chemical Structure
  39. GC60515 4-Ethylbenzaldehyde 4-Ethylbenzaldehyde Chemical Structure
  40. GC30600 4-Ethylphenol 4-Ethylphenol is a volatile phenolic compound associated with off-odour in wine. 4-Ethylphenol Chemical Structure
  41. GC62803 4-Formylaminoantipyrine 4-Formylaminoantipyrine?is an excreted metabolite of?aminophenazone. 4-Formylaminoantipyrine Chemical Structure
  42. GC30630 4-Guanidinobutanoic acid

    4-Guanidinobutanoic acid is a normal metabolite present in low concentrations.

     4-Guanidinobutanoic acid Chemical Structure
  43. GC40097 4-HOBA 4-HOBA is an endogenous metabolite. 4-HOBA Chemical Structure
  44. GC42410 4-hydroxy Nonenal

    A lipid peroxidation product

     4-hydroxy Nonenal Chemical Structure
  45. GC33656 4-Hydroxy-3-methylbenzoic acid 4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population. 4-Hydroxy-3-methylbenzoic acid Chemical Structure
  46. GC11270 4-Hydroxybenzoic acid A phenolic acid 4-Hydroxybenzoic acid Chemical Structure
  47. GC60518 4-Hydroxybenzyl cyanide 4-Hydroxybenzyl cyanide Chemical Structure
  48. GC35131 4-Hydroxycoumarin A coumarin 4-Hydroxycoumarin Chemical Structure
  49. GC33610 4-Hydroxycyclohexanecarboxylic acid 4-Hydroxycyclohexanecarboxylic acid belongs to the class of organic compounds known as cyclohexanols. 4-Hydroxycyclohexanecarboxylic acid Chemical Structure
  50. GC39691 4-Hydroxymethylpyrazole 4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole. 4-Hydroxymethylpyrazole Chemical Structure
  51. GC68055 4-Hydroxyphenyl acetate 4-Hydroxyphenyl acetate Chemical Structure
  52. GC33815 4-Hydroxyphenylacetic acid A phenolic acid with anti-inflammatory activity 4-Hydroxyphenylacetic acid Chemical Structure
  53. GC35134 4-Methoxybenzaldehyde 4-Methoxybenzaldehyde is a naturally occurring fragrant phenolic compound. 4-Methoxybenzaldehyde Chemical Structure
  54. GC35135 4-Methoxycinnamic acid 4-Methoxycinnamic acid is detected as natural phenylpropanoid in A. 4-Methoxycinnamic acid Chemical Structure
  55. GC60521 4-Methyl-1-phenyl-2-pentanone 4-Methyl-1-phenyl-2-pentanone is an endogenous metabolite. 4-Methyl-1-phenyl-2-pentanone Chemical Structure
  56. GC31307 4-Methyl-2-oxopentanoic acid 4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid), an abnormal metabolite, is both a neurotoxin and a metabotoxin. 4-Methyl-2-oxopentanoic acid Chemical Structure
  57. GC39780 4-Methylbiphenyl 4-Methylbiphenyl Chemical Structure
  58. GC30658 4-Methylcatechol 4-Methylcatechol, a metabolite of p-toluate, is a substrate as well as a suicide inhibitor of Catechol 2,3-Dioxygenase. 4-Methylcatechol Chemical Structure
  59. GC60524 4-Pentenoic acid 4-Pentenoic acid is an endogenous metabolite. 4-Pentenoic acid Chemical Structure
  60. GC30670 4-Pyridoxic acid A pyridoxine metabolite 4-Pyridoxic acid Chemical Structure
  61. GC60525 4-Vinylphenol (10%w/w in propylene glycol)

    4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.

     4-Vinylphenol (10%w/w in propylene glycol) Chemical Structure
  62. GC35126 4-​Hydroxyphenylpyruvic acid 4-Hydroxyphenylpyruvic acid is an intermediate in the metabolism of the amino acid phenylalanine. 4-​Hydroxyphenylpyruvic acid Chemical Structure
  63. GC60531 5α-Cholestan-3-one 5α-Cholestan-3-one is an endogenous metabolite. 5α-Cholestan-3-one Chemical Structure
  64. GC30669 5α-Cholestan-3β-ol (5α-Cholestanol) 5α-Cholestan-3β-ol (5α-Cholestanol) is a derivitized steroid compound. 5α-Cholestan-3β-ol (5α-Cholestanol) Chemical Structure
  65. GC38358 5'-Cytidylic acid 5'-Cytidylic acid (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. 5'-Cytidylic acid Chemical Structure
  66. GC33636 5'-Deoxyadenosine An adenosine analog 5'-Deoxyadenosine Chemical Structure
  67. GC35157 5'-GTP trisodium salt 5'-GTP trisodium salt (5'-GTP trisodium salt) is an activator of the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. 5'-GTP trisodium salt Chemical Structure
  68. GC35159 5'-Guanylic acid disodium salt 5'-Guanylic acid disodium salt (5'-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. 5'-Guanylic acid disodium salt Chemical Structure
  69. GC35152 5,6-Dihydro-5-methyluracil 5,6-Dihydro-5-methyluracil (Dihydrothymine), an intermediate breakdown product of thymine, comes from animal or plants. 5,6-Dihydro-5-methyluracil Chemical Structure
  70. GC33650 5,6-Dihydrouracil 5,6-Dihydrouracil (5,6-5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient. 5,6-Dihydrouracil Chemical Structure
  71. GC33502 5,6-Dihydrouridine

    A pyrimidine nucleoside and derivative of uridine

     5,6-Dihydrouridine Chemical Structure
  72. GC42484 5,6-dihydroxy Indole 5,6-dihydroxy Indole is an intermediate in melanogenesis. 5,6-dihydroxy Indole Chemical Structure
  73. GC38286 5,6-Dimethyl-1H-benzo[d]imidazole 5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite. 5,6-Dimethyl-1H-benzo[d]imidazole Chemical Structure
  74. GC38882 5-ALA benzyl ester hydrochloride 5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines. 5-ALA benzyl ester hydrochloride Chemical Structure
  75. GC35156 5-Amino-3H-imidazole-4-Carboxamide

    5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular.

     5-Amino-3H-imidazole-4-Carboxamide Chemical Structure
  76. GC32608 5-Amino-4-oxopentanoic acid 5-Amino-4-oxopentanoic acid (5-ALA) is a non-protein amino acid that plays a rate-limiting role in heme biosynthesis. 5-Amino-4-oxopentanoic acid Chemical Structure
  77. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  78. GC12713 5-Aminovaleric acid hydrochloride 5-Aminovaleric acid hydrochloride is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist. 5-Aminovaleric acid hydrochloride Chemical Structure
  79. GN10062 5-HTP 5-HTP Chemical Structure
  80. GC12829 5-hydroxy Tryptophol metabolite of tryptophan 5-hydroxy Tryptophol Chemical Structure
  81. GC60529 5-Hydroxy-2'-deoxyuridine 5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine Chemical Structure
  82. GC30613 5-Hydroxydopamine hydrochloride

    5-Hydroxydopamine is a naturally occurring amine in human urine.

     5-Hydroxydopamine hydrochloride Chemical Structure
  83. GC33698 5-Hydroxyindole-3-acetic acid A serotonin metabolite 5-Hydroxyindole-3-acetic acid Chemical Structure
  84. GC30189 5-Hydroxymethyl-2-furancarboxylic acid A major metabolite of 5-hydroxymethyl-2-furfural 5-Hydroxymethyl-2-furancarboxylic acid Chemical Structure
  85. GC33613 5-Hydroxymethyluracil Product of oxidative damage to DNA 5-Hydroxymethyluracil Chemical Structure
  86. GC62810 5-Hydroxytryptamine creatinine sulfate monohydrate 5-Hydroxytryptamine creatinine sulfate monohydrate is an endogenous metabolite. 5-Hydroxytryptamine creatinine sulfate monohydrate Chemical Structure
  87. GC67951 5-Hydroxytryptophol-d4 5-Hydroxytryptophol-d4 Chemical Structure
  88. GC62811 5-Methoxy-5-oxopentanoic acid 5-Methoxy-5-oxopentanoic acid is an endogenous metabolite. 5-Methoxy-5-oxopentanoic acid Chemical Structure
  89. GC38058 5-Methoxy-DL-tryptophan An active metabolite of tryptophan 5-Methoxy-DL-tryptophan Chemical Structure
  90. GC46078 5-Methoxyindole-3-acetic acid A methoxyindole 5-Methoxyindole-3-acetic acid Chemical Structure
  91. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  92. GC30712 5-Methoxytryptophol A natural indole 5-Methoxytryptophol Chemical Structure
  93. GC42562 5-Methyl-2'-deoxycytidine 5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  94. GC33526 5-Methylcytidine A modified nucleoside 5-Methylcytidine Chemical Structure
  95. GC35166 5-Methylcytosine 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine Chemical Structure
  96. GC34881 5-Methyltetrahydrofolic acid 5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid Chemical Structure
  97. GC33514 5-Methyluridine A pyrimidine nucleoside 5-Methyluridine Chemical Structure
  98. GC68228 5-Nitro-1,10-phenanthroline 5-Nitro-1,10-phenanthroline Chemical Structure
  99. GC62814 5-Phenylvaleric acid 5-Phenylvaleric acid (5-Phenylpentanoic acid) is a pentanoic acid of bacterial origin, occasionally found in human biofluids. 5-Phenylvaleric acid Chemical Structure
  100. GC32410 5a-Pregnane-3,20-dione A progesterone receptor agonist and progesterone metabolite 5a-Pregnane-3,20-dione Chemical Structure
  101. GC68374 5a-Pregnane-3,20-dione-d6 5a-Pregnane-3,20-dione-d6 Chemical Structure

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