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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Targets for  Endogenous Metabolite

Products for  Endogenous Metabolite

  1. Cat.No. Product Name Information
  2. GC33704 6-Hydroxymelatonin 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2. 6-Hydroxymelatonin Chemical Structure
  3. GC38278 6-Hydroxynicotinic acid 6-Hydroxynicotinic acid Chemical Structure
  4. GC10067 6-Hydroxynicotinic acid NULL 6-Hydroxynicotinic acid Chemical Structure
  5. GC62816 6-Hydroxypyridin-2(1H)-one hydrochloride 6-Hydroxypyridin-2(1H)-one hydrochloride is an endogenous metabolite. 6-Hydroxypyridin-2(1H)-one hydrochloride Chemical Structure
  6. GC64741 6-Methylnicotinamide 6-Methylnicotinamide, a derivate of nicotinamide, is an endogenous metabolite. 6-Methylnicotinamide Chemical Structure
  7. GC65015 6-Phosphogluconic acid trisodium 6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium Chemical Structure
  8. GC40087 7α-hydroxy-4-Cholesten-3-one

    7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids.

     7α-hydroxy-4-Cholesten-3-one Chemical Structure
  9. GC10533 7,8-dihydro-L-Biopterin A precursor in the synthesis of BH4 7,8-dihydro-L-Biopterin Chemical Structure
  10. GC45673 7,8-Dihydroneopterin An antioxidant 7,8-Dihydroneopterin Chemical Structure
  11. GC33450 7-Dehydrocholesterol An immediate precursor to cholesterol 7-Dehydrocholesterol Chemical Structure
  12. GC39474 7-Ketolithocholic acid 7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid) is a kind of bile acid, 7-Ketolithocholic acid can be absorbed, 7-ketolithocholic acid inhibits the production of endogenous bile acid, and can affect the secretion of biliary cholestero. 7-Ketolithocholic acid Chemical Structure
  13. GC33616 7-Methylguanine 7-Methylguanine is a metabolite of DNA methylation. 7-Methylguanine Chemical Structure
  14. GC62817 7-Methylguanosine 5’-diphosphate sodium 7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues. 7-Methylguanosine 5’-diphosphate sodium Chemical Structure
  15. GC31617 7-Methylxanthine 7-Methylxanthine, a methyl derivative of xanthine, is one of the purine components in urinary calculi. 7-Methylxanthine Chemical Structure
  16. GC14433 7α,25-dihydroxy Cholesterol A GPR183 agonist 7α,25-dihydroxy Cholesterol Chemical Structure
  17. GC18544 8-dehydro Cholesterol

    8-dehydro Cholesterol (8-DHC) is an isomer of the cholesterol precursor 7-DHC .

     8-dehydro Cholesterol Chemical Structure
  18. GC40926 8-Hydroxy-2'-deoxyguanosine 8-Hydroxy-2'-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. 8-Hydroxy-2'-deoxyguanosine Chemical Structure
  19. GC35204 8-Hydroxyguanine 8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. 8-Hydroxyguanine Chemical Structure
  20. GC31219 8-Hydroxyguanosine Product of oxidative damage to RNA 8-Hydroxyguanosine Chemical Structure
  21. GC18515 8-iso Prostaglandin F2α 8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-iso Prostaglandin F2α Chemical Structure
  22. GC18994 8-iso Prostaglandin F2β 8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. 8-iso Prostaglandin F2β Chemical Structure
  23. GC18389 9-cis Retinal 9-cis Retinal is a natural retinoid that is produced by oxidation of 9-cis retinol by cis-retinol dehydrogenase (cRDH). 9-cis Retinal Chemical Structure
  24. GC38883 9-Ethyladenine 9-Ethyladenine is a partially effective inhibitor of APRT (adenine phosphoribosyltransferase). 9-Ethyladenine Chemical Structure
  25. GC38264 Ac-Ala-OH Ac-Ala-OH Chemical Structure
  26. GA11174 Ac-Arg-OH.2H2O Ac-Arg-OH.2H2O Chemical Structure
  27. GA20489 Ac-Asn-OH Ac-Asn-OH is an endogenous metabolite. Ac-Asn-OH Chemical Structure
  28. GA10446 Ac-DL-Trp-OH Ac-DL-Trp-OH Chemical Structure
  29. GA10356 Ac-Gly-OH Ac-Gly-OH Chemical Structure
  30. GA10825 Ac-His-OH Ac-His-OH Ac-His-OH Chemical Structure
  31. GA20612 Ac-Lys-OH Ac-Lys-OH is an endogenous metabolite. Ac-Lys-OH Chemical Structure
  32. GA20680 Ac-Val-OH Ac-Val-OH Chemical Structure
  33. GC35228 Aceglutamide Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration. Aceglutamide Chemical Structure
  34. GC38317 Acetamide Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide Chemical Structure
  35. GC12917 Acetaminophen

    A COX inhibitor

     Acetaminophen Chemical Structure
  36. GC64137 Acetaminophen-d3 Acetaminophen-d3 Chemical Structure
  37. GC42697 Acetyl Coenzyme A (sodium salt) Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl Coenzyme A (sodium salt) Chemical Structure
  38. GC60555 Acetyl phosphate(lithium potassium) Acetyl phosphate(lithium potassium) is an endogenous metabolite. Acetyl phosphate(lithium potassium) Chemical Structure
  39. GC46789 Acetyl-L-carnitine-d3 (chloride) An internal standard for the quantification of L-acetylcarnitine Acetyl-L-carnitine-d3 (chloride) Chemical Structure
  40. GC68097 Acetyl-L-carnitine-d3 hydrochloride Acetyl-L-carnitine-d3 hydrochloride Chemical Structure
  41. GC14142 Acetylcholine Chloride Major transmitter at many nervous sites Acetylcholine Chloride Chemical Structure
  42. GC11786 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. Acetylcysteine Chemical Structure
  43. GC13432 Adenine High affinity adenine receptor agonist Adenine Chemical Structure
  44. GC62828 Adenine monohydrochloride hemihydrate Adenine monohydrochloride hemihydrate is an endogenous metabolite. Adenine monohydrochloride hemihydrate Chemical Structure
  45. GC17278 Adenine sulfate Adenine sulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine sulfate acts as a chemical component of DNA and RNA. Adenine sulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis. Adenine sulfate Chemical Structure
  46. GC14106 Adenosine nucleoside Adenosine Chemical Structure
  47. GC19630 Adenosine 2′-monophosphate Adenosine 2′-monophosphate (2'-AMP) is converted by extracellular 2',3'-CAMP. Adenosine 2′-monophosphate Chemical Structure
  48. GC10880 Adenosine 3-5-cyclic monophosphate A second messenger Adenosine 3-5-cyclic monophosphate Chemical Structure
  49. GC17558 Adenosine 5'-triphosphate disodium salt hydrate Adenosine 5'-triphosphate disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate disodium salt hydrate Chemical Structure
  50. GC13172 Adenosine 5-monophosphate Adenosine 5-monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction. Adenosine 5-monophosphate Chemical Structure
  51. GC11969 Adenosine-5'-diphosphate Agonist of purinergic receptors Adenosine-5'-diphosphate Chemical Structure
  52. GC64916 Adenylosuccinic acid tetraammonium Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium Chemical Structure
  53. GC33805 Adipic acid Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. Adipic acid Chemical Structure
  54. GC31602 Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) Chemical Structure
  55. GC35261 Aflatoxin B1 Aflatoxin B1, as a class of carcinogenic mycotoxins produced by Aspergillus fungi, always lead to the development of hepatocellular carcinoma (HCC) in humans and animals. Aflatoxin B1 Chemical Structure
  56. GC16831 Agmatine sulfate α2-adrenergic receptor ligand Agmatine sulfate Chemical Structure
  57. GC41390 Aldosterone

    Aldosterone is a steroid hormone secreted by the adrenal cortex and is the principle mineralocorticoid controlling sodium and potassium balance

     Aldosterone Chemical Structure
  58. GC19584 Alkaline Phosphatase

    10-50units/mg protein(37℃,pH 9.8)

     Alkaline Phosphatase Chemical Structure
  59. GC14511 all-trans Retinal converted to retinoic acid in vivo all-trans Retinal Chemical Structure
  60. GC31420 all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid), an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) Chemical Structure
  61. GC61487 all-trans-Anhydro Retinol all-trans-Anhydro Retinol (Anhydrovitamin A) is a metabolite of Vitamin A. all-trans-Anhydro Retinol Chemical Structure
  62. GC60574 Allantoic acid Allantoic acid is a degradative product of uric acid and associated with purine metabolism. Allantoic acid Chemical Structure
  63. GN10492 Allantoin Allantoin Chemical Structure
  64. GC33807 Alloepipregnanolone An Analytical Reference Standard Alloepipregnanolone Chemical Structure
  65. GC35295 Allopurinol riboside A ribonucleoside Allopurinol riboside Chemical Structure
  66. GC38734 Allotetrahydrocortisol Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Allotetrahydrocortisol Chemical Structure
  67. GC38885 alpha-D-glucose alpha-D-glucose is an endogenous metabolite. alpha-D-glucose Chemical Structure
  68. GC19750 alpha-L-Rhamnose alpha-L-Rhamnose Chemical Structure
  69. GC17347 Alprostadil Alprostadil (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Alprostadil Chemical Structure
  70. GC35320 Aminoadipic acid Aminoadipic acid is an intermediate in the metabolism of lysine and saccharopine. Aminoadipic acid Chemical Structure
  71. GC35321 Aminomalonic acid Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis. Aminomalonic acid Chemical Structure
  72. GC35339 Anandamide An immune modulator in the central nervous system Anandamide Chemical Structure
  73. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  74. GC61496 Angiotensin (1-7) (acetate) Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin (1-7) (acetate) Chemical Structure
  75. GC35355 Angiotensin III Angiotensin III Chemical Structure
  76. GC35356 Angiotensin III TFA Angiotensin III TFA Chemical Structure
  77. GC32604 Angiotensinogen (1-14), human Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen (1-14), human Chemical Structure
  78. GC30722 Anserine Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine Chemical Structure
  79. GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Antineoplaston A10 Chemical Structure
  80. GC61691 Arabinose Arabinose is an endogenous metabolite. Arabinose Chemical Structure
  81. GC35379 Arachidic acid A longchain saturated fatty acid Arachidic acid Chemical Structure
  82. GC31725 Arachidonic acid (Immunocytophyt) Arachidonic acid (Immunocytophyt) is an essential fatty acid and a major constituent of biomembranes. Arachidonic acid (Immunocytophyt) Chemical Structure
  83. GC67243 Arachidonoyl coenzyme A lithium Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid. Arachidonoyl coenzyme A lithium Chemical Structure
  84. GC42846 Arachidonoyl-L-carnitine (chloride)

    Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism.

     Arachidonoyl-L-carnitine (chloride) Chemical Structure
  85. GC30675 Argininic acid Argininic acid is an α-amino acid that is used in the biosynthesis of proteins. Argininic acid Chemical Structure
  86. GC32457 Asymmetric dimethylarginine An endogenous NOS inhibitor Asymmetric dimethylarginine Chemical Structure
  87. GC35420 ATP

    ATP, as a phosphate-group donor for substrate activation in metabolic reactions.

     ATP Chemical Structure
  88. GC61448 ATP disodium trihydrate ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate Chemical Structure
  89. GC46893 Atranorin A depside lichen metabolite with diverse biological activities Atranorin Chemical Structure
  90. GC11843 Azaguanine-8 Azaguanine-8 is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth. Azaguanine-8 Chemical Structure
  91. GC30219 Azelaic acid (Nonanedioic acid) Azelaic acid (Nonanedioic acid) is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners. Azelaic acid (Nonanedioic acid) Chemical Structure
  92. GC38143 Batilol 3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite. Batilol Chemical Structure
  93. GC50134 Bengamide B Potent inhibitor of NF-κB activation Bengamide B Chemical Structure
  94. GC63577 Benzamide-15N Benzamide-15N (Benzenecarboxamide-15N) is a 15N-labeled Benzamide. Benzamide-15N Chemical Structure
  95. GC65332 Benzoic acid-13C6 Benzoic acid-13C6 Chemical Structure
  96. GC60633 Benzophenone Benzophenone is an endogenous metabolite. Benzophenone Chemical Structure
  97. GC60640 Benzylideneacetone Benzylideneacetone is an endogenous metabolite. Benzylideneacetone Chemical Structure
  98. GC30727 Beta-Cortol An endogenous metabolite of cortisol Beta-Cortol Chemical Structure
  99. GC19134 beta-D-(-)-Arabinose beta-D-(-)-Arabinose Chemical Structure
  100. GC10582 Betacarotene Betacarotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. Betacarotene Chemical Structure
  101. GN10555 Bilirubin Bilirubin Chemical Structure

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