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Home >> Lipids >> P450

P450

Products for  P450

  1. Cat.No. Product Name Information
  2. GC41128 5(S),6(R)-11-trans DiHETE 5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE Chemical Structure
  3. GC61814 5,7-Dimethoxyflavone 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone Chemical Structure
  4. GC42546 5-hydroxy Diclofenac 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. 5-hydroxy Diclofenac Chemical Structure
  5. GC41312 5-hydroxy Omeprazole

    5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.

     5-hydroxy Omeprazole Chemical Structure
  6. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. 5-hydroxy-6-methoxy (S)-Duloxetine Chemical Structure
  7. GC42551 5-hydroxymethyl Tolterodine (formate) 5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine. 5-hydroxymethyl Tolterodine (formate) Chemical Structure
  8. GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8. 6α-hydroxy Paclitaxel Chemical Structure
  9. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone 6β-hydroxy Eplerenone Chemical Structure
  10. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone Chemical Structure
  11. GC41302 6',7'-Epoxybergamottin 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. 6',7'-Epoxybergamottin Chemical Structure
  12. GC42580 6-hydroxy Chlorzoxazone

    6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.

     6-hydroxy Chlorzoxazone Chemical Structure
  13. GC18219 6-hydroxy Warfarin 6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin . 6-hydroxy Warfarin Chemical Structure
  14. GC49429 6-keto Lithocholic Acid A metabolite of lithocholic acid 6-keto Lithocholic Acid Chemical Structure
  15. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil Chemical Structure
  16. GC18335 6β-hydroxy Dexamethasone 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. 6β-hydroxy Dexamethasone Chemical Structure
  17. GC52062 7-Benzyloxy-4-(trifluoromethyl)coumarin A fluorogenic substrate for CYP1A2 and CYP3A 7-Benzyloxy-4-(trifluoromethyl)coumarin Chemical Structure
  18. GC49320 7-Ethoxy-4-(trifluoromethyl)coumarin A fluorogenic substrate for CYPs 7-Ethoxy-4-(trifluoromethyl)coumarin Chemical Structure
  19. GC49030 7-Ethoxycoumarin A CYP450 substrate 7-Ethoxycoumarin Chemical Structure
  20. GC40572 7-keto Cholesterol A bioactive sterol and a major oxysterol component of oxidized LDL 7-keto Cholesterol Chemical Structure
  21. GC46241 7-keto Cholesterol-d7

    7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL

     7-keto Cholesterol-d7 Chemical Structure
  22. GC35201 8-Geranyloxypsoralen 8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM. 8-Geranyloxypsoralen Chemical Structure
  23. GC42626 8-hydroxy Efavirenz 8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz. 8-hydroxy Efavirenz Chemical Structure
  24. GC18654 8-hydroxy Loxapine 8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. 8-hydroxy Loxapine Chemical Structure
  25. GC49544 8-hydroxy Mirtazapine A metabolite of mirtazapine 8-hydroxy Mirtazapine Chemical Structure
  26. GC40464 9(R)-HETE 9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(R)-HETE Chemical Structure
  27. GC40465 9(S)-HETE 9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE. 9(S)-HETE Chemical Structure
  28. GC63469 Abiraterone-D4 Abiraterone-D4 (CB-7598-D4) is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively. Abiraterone-D4 Chemical Structure
  29. GC14781 ABT (1-Aminobenzotriazole) ABT (1-Aminobenzotriazole) is a nonspecific and irreversible inhibitor of cytochrome P450 (P450). ABT (1-Aminobenzotriazole) Chemical Structure
  30. GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin Chemical Structure
  31. GC40638 Alclometasone Dipropionate Alclometasone dipropionate (ACM) is a corticosteroid. Alclometasone Dipropionate Chemical Structure
  32. GC18539 all-trans-4-hydroxy Retinoic Acid all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1. all-trans-4-hydroxy Retinoic Acid Chemical Structure
  33. GC46835 Alyssin An isothiocyanate with diverse biological activities Alyssin Chemical Structure
  34. GC46842 Amiodarone-d4 (hydrochloride) An internal standard for the quantification of amiodarone Amiodarone-d4 (hydrochloride) Chemical Structure
  35. GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Antihistamine-1 Chemical Structure
  36. GC52024 Aripiprazole N-oxide A metabolite of aripiprazole Aripiprazole N-oxide Chemical Structure
  37. GC61574 AS1810722 AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 Chemical Structure
  38. GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone Atorvastatin lactone-d5 Chemical Structure
  39. GC65088 Atovaquone-d5 Atovaquone-d5 Chemical Structure
  40. GC42878 Avanafil metabolite M16 Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil metabolite M16 Chemical Structure
  41. GC42879 Avanafil metabolite M4 Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil metabolite M4 Chemical Structure
  42. GC42887 Axitinib Sulfoxide Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib. Axitinib Sulfoxide Chemical Structure
  43. GC42888 Azamulin

    Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources).

     Azamulin Chemical Structure
  44. GC49403 Benzarone An active metabolite of benzbromarone Benzarone Chemical Structure
  45. GC34132 Bergamottin (5-Geranoxypsoralen) Bergamottin (5-Geranoxypsoralen) is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM. Bergamottin (5-Geranoxypsoralen) Chemical Structure
  46. GC33909 Bergaptol (5-Hydroxypsoralen) Bergaptol (5-Hydroxypsoralen) is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Bergaptol (5-Hydroxypsoralen) Chemical Structure
  47. GC65345 BI 653048 BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM. BI 653048 Chemical Structure
  48. GC32419 BI 689648 BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively. BI 689648 Chemical Structure
  49. GC46933 Bitertanol A triazole fungicide Bitertanol Chemical Structure
  50. GC31479 BMS-819881 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 Chemical Structure
  51. GC62491 BMS-986202 BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 of 0.19 nM and a Ki of 0.02 nM. BMS-986202 Chemical Structure
  52. GC45887 Bufuralol-d9 (hydrochloride) An internal standard for the quantification of bufuralol Bufuralol-d9 (hydrochloride) Chemical Structure
  53. GC32257 Carbosulfan Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan Chemical Structure
  54. GC47040 Carebastine-d5 An internal standard for the quantification of carebastine Carebastine-d5 Chemical Structure
  55. GC41264 CAY10434 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10434 Chemical Structure
  56. GC43158 CAY10462 20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. CAY10462 Chemical Structure
  57. GC18879 CAY10662 17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM). CAY10662 Chemical Structure
  58. GC18698 CAY10665 Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA). CAY10665 Chemical Structure
  59. GC47064 CAY10770 An inhibitor of CYP4Z1 CAY10770 Chemical Structure
  60. GC31464 CDD3505 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. CDD3505 Chemical Structure
  61. GC31460 CDD3506 CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. CDD3506 Chemical Structure
  62. GC32991 Cecropin B Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic. Cecropin B Chemical Structure
  63. GC38681 Cedrol A sesquiterpene alcohol Cedrol Chemical Structure
  64. GC16751 Chlorzoxazone Muscle-relaxing drug Chlorzoxazone Chemical Structure
  65. GC35692 Chrysosplenetin A flavonoid with diverse biological activities Chrysosplenetin Chemical Structure
  66. GC43278 Clindamycin Sulfoxide Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin. Clindamycin Sulfoxide Chemical Structure
  67. GC38758 Clomethiazole Chlormethiazole is an potent and orally active GABAA?agonist. Clomethiazole Chemical Structure
  68. GC49096 Cobaltic Protoporphyrin IX (chloride) An inducer of HO-1 activity Cobaltic Protoporphyrin IX (chloride) Chemical Structure
  69. GC47118 Colchicoside A glycoside form of 3-demethylcolchicine Colchicoside Chemical Structure
  70. GC49146 Colupulone A β-acid with diverse biological activities Colupulone Chemical Structure
  71. GC41611 Curcumenol Curcumenol is a sesquiterpene that has been found in Curcuma species. Curcumenol Chemical Structure
  72. GC49410 CVT-2738 An active metabolite of ranolazine CVT-2738 Chemical Structure
  73. GC35788 CYP17-IN-1 CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. CYP17-IN-1 Chemical Structure
  74. GC35803 Dafadine-A Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). Dafadine-A Chemical Structure
  75. GC62304 Dapaconazole Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM. Dapaconazole Chemical Structure
  76. GC43400 Dehydro Aripiprazole (hydrochloride) Dehydro aripiprazole is the primary, active metabolite of aripiprazole, an atypical antipsychotic. Dehydro Aripiprazole (hydrochloride) Chemical Structure
  77. GC43401 Dehydro Nifedipine Dehydro nifedipine is an active metabolite of nifedipine, a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro Nifedipine Chemical Structure
  78. GC45650 Des(benzylpyridyl) Atazanavir A metabolite of atazanavir Des(benzylpyridyl) Atazanavir Chemical Structure
  79. GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine Desethyl Hydroxychloroquine-d4 Chemical Structure
  80. GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine Desethylchloroquine-d4 Chemical Structure
  81. GC49202 Desmethyl Mirtazapine (hydrochloride) A metabolite of mirtazapine Desmethyl Mirtazapine (hydrochloride) Chemical Structure
  82. GC49409 Desmethyl Ranolazine A metabolite of ranolazine Desmethyl Ranolazine Chemical Structure
  83. GC52038 Desthiazolylmethyl Ritonavir A ritonavir degradation product Desthiazolylmethyl Ritonavir Chemical Structure
  84. GC18252 Diallyl Sulfide An organosulfur compound Diallyl Sulfide Chemical Structure
  85. GC43440 Dibenzylfluorescein

    Dibenzylfluorescein is a fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19).

     Dibenzylfluorescein Chemical Structure
  86. GC30479 Dihydromethysticin ((+)-Dihydromethysticin) Dihydromethysticin ((+)-Dihydromethysticin) is one of the six major kavalactones found in the kava plant; has marked activity on the induction of CYP3A23. Dihydromethysticin ((+)-Dihydromethysticin) Chemical Structure
  87. GC16550 Diosmetin CYP1A1 inhibitor Diosmetin Chemical Structure
  88. GC47234 Diosmetin-d3 An internal standard for the quantification of diosmetin Diosmetin-d3 Chemical Structure
  89. GC19415 DMU2105 DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. DMU2105 Chemical Structure
  90. GC19416 DMU2139 DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. DMU2139 Chemical Structure
  91. GC49288 Dolutegravir M1 A metabolite of dolutegravir Dolutegravir M1 Chemical Structure
  92. GC12892 Doxepin (hydrochloride) histamine, serotonin, adrenergic, and muscarinic receptors antagonist Doxepin (hydrochloride) Chemical Structure
  93. GC60791 Doxepin D3 Hydrochloride Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin D3 Hydrochloride Chemical Structure
  94. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 Chemical Structure
  95. GC35981 EMT inhibitor-2 EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 Chemical Structure
  96. GC43621 Epoxy Fluor 7 Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity. Epoxy Fluor 7 Chemical Structure
  97. GC43626 Erythromycin A N-oxide Erythromycin A N-oxide is a potential impurity found in commercial preparations of erythromycin. Erythromycin A N-oxide Chemical Structure
  98. GC43627 Erythromycin lactobionate A macrolide antibiotic Erythromycin lactobionate Chemical Structure
  99. GC12250 Fenofibrate

    PPARα agonist

     Fenofibrate Chemical Structure
  100. GC49230 Ferroprotoporphyrin Ferroprotoporphyrin, a complex of ferrous iron and a porphyrin, is an isosteric inhibitor of fatty acid binding to rat liver fatty acid binding protein. Ferroprotoporphyrin Chemical Structure
  101. GC60167 Fipronil An insecticide Fipronil Chemical Structure

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