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Home >> Lipids >> P450

P450

Products for  P450

  1. Cat.No. Product Name Information
  2. GC47367 Fluvastatin (sodium salt hydrate) An HMG-CoA reductase inhibitor Fluvastatin (sodium salt hydrate) Chemical Structure
  3. GC38623 Fraxinol Fraxinol is isolated from Lobelia chinensis. Fraxinol Chemical Structure
  4. GC60169 Friedelin Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin Chemical Structure
  5. GC32855 Furafylline

    Furafylline, as a long-acting replacement for theophylline in the treatment of asthma, is a methylxanthine derivative[1].

     Furafylline Chemical Structure
  6. GC14915 Gemfibrozil PPARα activator Gemfibrozil Chemical Structure
  7. GC43743 Gemfibrozil 1-O-β-Glucuronide Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-Glucuronide Chemical Structure
  8. GC39168 GSK2945 hydrochloride GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride Chemical Structure
  9. GC11540 HET0016 inhibitor of 20-HETE formation HET0016 Chemical Structure
  10. GC43879 Hydroxy Ebastine Hydroxy Ebastine is an ebastine metabolite. Hydroxy Ebastine Chemical Structure
  11. GC49559 Hydroxymethyl Tolperisone (hydrochloride) A metabolite of tolperisone Hydroxymethyl Tolperisone (hydrochloride) Chemical Structure
  12. GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide Indapamide-13C-d3 Chemical Structure
  13. GC60202 Inz-1 Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 Chemical Structure
  14. GC16707 Isavuconazole triazole antifungal drug Isavuconazole Chemical Structure
  15. GC36335 Isoglycycoumarin Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin Chemical Structure
  16. GC60212 K777 A cysteine protease inhibitor K777 Chemical Structure
  17. GC44033 Lansoprazole sulfone Lansoprazole sulfone is a phase I metabolite of lansoprazole. Lansoprazole sulfone Chemical Structure
  18. GC38554 Liarozole dihydrochloride Liarozole dihydrochloride is a P-450 inhibitor and retinoic acid (RA) metabolizing blocking agent inhibits RA metabolism and thereby increases intracellular RA levels in cells that actively produce RA. Liarozole dihydrochloride Chemical Structure
  19. GC67933 LKY-047 LKY-047 Chemical Structure
  20. GC31422 MCH-1 antagonist 1

    MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM.

     MCH-1 antagonist 1 Chemical Structure
  21. GC45508 MEGX (hydrochloride)   MEGX (hydrochloride) Chemical Structure
  22. GC10198 Memantine hydrochloride NMDA receptor antagonist Memantine hydrochloride Chemical Structure
  23. GC50038 Mephenytoin CYP2C19 substrate. Anticonvulsant Mephenytoin Chemical Structure
  24. GC41373 Methysticin Methysticin is a kavalactone isolated from the kava roots. Methysticin Chemical Structure
  25. GC30985 Methysticin (DL-Methysticin) Methysticin (DL-Methysticin) Chemical Structure
  26. GC17411 Metyrapone 11-β hydroxylase (CYP11B1) inhibitor Metyrapone Chemical Structure
  27. GC49185 Mirtazapine N-oxide A metabolite of mirtazapine Mirtazapine N-oxide Chemical Structure
  28. GC16423 Monoacetylphloroglucinol Monoacetylphloroglucinol (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Monoacetylphloroglucinol Chemical Structure
  29. GC19483 MS-PPOH Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway. MS-PPOH Chemical Structure
  30. GC44299 N-Acetyl-4-benzoquinone imine N-Acetyl-4-benzoquinone imine is the toxic metabolite of Acetaminophen. N-Acetyl-4-benzoquinone imine Chemical Structure
  31. GC49399 N-Desbutyl Dronedarone (hydrochloride) Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. N-Desbutyl Dronedarone (hydrochloride) Chemical Structure
  32. GC44345 N-Desethyl Vardenafil N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5. N-Desethyl Vardenafil Chemical Structure
  33. GC52045 N-desmethyl Azelastine N-desmethyl Azelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. N-desmethyl Azelastine Chemical Structure
  34. GC44348 N-desmethyl Bendamustine N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine. N-desmethyl Bendamustine Chemical Structure
  35. GC52132 N-desmethyl Diltiazem (hydrochloride) N-desmethyl Diltiazem (hydrochloride) Chemical Structure
  36. GC48804 N-desmethyl Olanzapine A major metabolite of olanzapine N-desmethyl Olanzapine Chemical Structure
  37. GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib N-desmethyl Regorafenib N-oxide Chemical Structure
  38. GC41380 N-desmethyl Rosiglitazone N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone, a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. N-desmethyl Rosiglitazone Chemical Structure
  39. GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin N-desmethyl Rosuvastatin (sodium salt hydrate) Chemical Structure
  40. GC49583 N-desmethyl Sertraline (hydrochloride) A metabolite of sertraline N-desmethyl Sertraline (hydrochloride) Chemical Structure
  41. GC44350 N-Desmethyl Sildenafil N-Desmethyl sildenafil is a major metabolite of sildenafil. N-Desmethyl Sildenafil Chemical Structure
  42. GC44351 N-Desmethyl Sildenafil (citrate) N-Desmethyl sildenafil is a major metabolite of sildenafil. N-Desmethyl Sildenafil (citrate) Chemical Structure
  43. GC49133 N-hydroxy Riluzole A metabolite of riluzole N-hydroxy Riluzole Chemical Structure
  44. GC52007 N-hydroxylamine Dapsone An active metabolite of dapsone N-hydroxylamine Dapsone Chemical Structure
  45. GC36754 N-Nornuciferine N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. N-Nornuciferine Chemical Structure
  46. GC62476 Nampt-IN-5 Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 Chemical Structure
  47. GC49501 Nirvanol An active metabolite of mephenytoin Nirvanol Chemical Structure
  48. GC44451 Norfluoxetine (hydrochloride)

    Norfluoxetine is an active metabolite of the antidepressant fluoxetine that inhibits serotonin uptake with a pKi value of 7.35.

     Norfluoxetine (hydrochloride) Chemical Structure
  49. GC49355 Norfluoxetine-d5 (hydrochloride) An internal standard for the quantification of norfluoxetine Norfluoxetine-d5 (hydrochloride) Chemical Structure
  50. GC52019 Norpropranolol (hydrochloride) An active metabolite of propranolol Norpropranolol (hydrochloride) Chemical Structure
  51. GC44492 O-Desmethyl Metoprolol O-Desmethyl metoprolol is the major active metabolite of the β1-adrenergic receptor blocker metoprolol. O-Desmethyl Metoprolol Chemical Structure
  52. GC69602 Obtusifoliol

    Obtusifoliol is a specific CYP51 inhibitor, with Kd values of 1.2 μM and 1.4 μM for the affinity to Brucella melitensis (TB) and human CYP51, respectively.

     Obtusifoliol Chemical Structure
  53. GC30966 Olivetol Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol Chemical Structure
  54. GC11155 Omeprazole sulfone Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor. Omeprazole sulfone Chemical Structure
  55. GC36822 Oteseconazole Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51. Oteseconazole Chemical Structure
  56. GC44554 Pantoprazole Sulfide Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole. Pantoprazole Sulfide Chemical Structure
  57. GC44555 Pantoprazole sulfone Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole. Pantoprazole sulfone Chemical Structure
  58. GC47923 Paraxanthine-d6 An internal standard for the quantification of paraxanthine Paraxanthine-d6 Chemical Structure
  59. GC48493 PCI 45227 PCI 45227 (PCI-45227) is a dihydrodiolactive metabolite of Ibrutinib, has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib. PCI 45227 Chemical Structure
  60. GC38421 Phillyrin (Forsythin) Phillyrin (Forsythin) is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin (Forsythin) Chemical Structure
  61. GC41339 Pioglitazone Ketone Pioglitazone ketone is an active metabolite of the PPARγ agonist pioglitazone. Pioglitazone Ketone Chemical Structure
  62. GC61191 Piperonylic acid Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid Chemical Structure
  63. GC19301 Pradefovir mesylate Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir mesylate Chemical Structure
  64. GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole Propiconazole-d7 Chemical Structure
  65. GC18791 Prostaglandin H1 Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes. Prostaglandin H1 Chemical Structure
  66. GC33862 Pyributicarb (TSH-888) Pyributicarb (TSH-888), a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb (TSH-888) Chemical Structure
  67. GC37061 Quilseconazole Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes. Quilseconazole Chemical Structure
  68. GC44799 Quinidine N-oxide Quinidine N-oxide is a pharmacologically inactive quinidine metabolite. Quinidine N-oxide Chemical Structure
  69. GC49627 Rabeprazole sulfone A metabolite of rabeprazole Rabeprazole sulfone Chemical Structure
  70. GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine rac-N-desmethyl Ivabradine-d6 (hydrochloride) Chemical Structure
  71. GC48461 rac-trans-4-hydroxy Glyburide An active metabolite of glyburide rac-trans-4-hydroxy Glyburide Chemical Structure
  72. GC44819 Resorufin benzyl ether Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. Resorufin benzyl ether Chemical Structure
  73. GC30681 Revexepride Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease. Revexepride Chemical Structure
  74. GC33780 RG-12525 (NID 525) RG-12525 (NID 525) is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 (NID 525) is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 μM. RG-12525 (NID 525) Chemical Structure
  75. GC13470 Rhapontigenin inactivator of cytochrome P450 1A1 with antioxidant and anti-cancer activity Rhapontigenin Chemical Structure
  76. GC18460 Roquefortine C Roquefortine C is a mycotoxin that was first isolated from a strain of P. Roquefortine C Chemical Structure
  77. GC49107 Rosuvastatin lactone The lactone form of rosuvastatin Rosuvastatin lactone Chemical Structure
  78. GC44907 S-NEPC Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. S-NEPC Chemical Structure
  79. GC61465 SDZ285428 SDZ285428 is a CYP51 inhibitor. SDZ285428 Chemical Structure
  80. GC30459 Senecionine (Senecionan-11,16-dione, 12-hydroxy-) Senecionine (Senecionan-11,16-dione, 12-hydroxy-) (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) Chemical Structure
  81. GC44882 Seneciphylline Seneciphylline is an alkaloid that has been found F. Seneciphylline Chemical Structure
  82. GC37631 Seviteronel Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. Seviteronel Chemical Structure
  83. GC37632 Seviteronel racemate Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition. Seviteronel racemate Chemical Structure
  84. GC16259 SKF 525A (hydrochloride) SKF 525A (hydrochloride) is a Cytochrome P450 inhibitor (IC50 = 19μM). SKF 525A (hydrochloride) Chemical Structure
  85. GC44917 Sorafenib N-oxide Sorafenib N-oxide is an active metabolite of sorafenib, an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide Chemical Structure
  86. GC63199 Soticlestat Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat Chemical Structure
  87. GC49281 SPA70 A PXR antagonist SPA70 Chemical Structure
  88. GC18706 SR 9186 A selective inhibitor of CYP3A4 SR 9186 Chemical Structure
  89. GC16951 Stiripentol An LDH inhibitor Stiripentol Chemical Structure
  90. GC11638 Sulfaphenazole CYP2C9 inhibitor Sulfaphenazole Chemical Structure
  91. GC44975 SW203668 (trifluoroacetate salt) SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). SW203668 (trifluoroacetate salt) Chemical Structure
  92. GC37727 Talarozole R enantiomer Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Talarozole R enantiomer Chemical Structure
  93. GC40301 Tamoxifen N-oxide Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide Chemical Structure
  94. GC32160 Tebuconazole A triazole fungicide Tebuconazole Chemical Structure
  95. GC49055 Tebuconazole-d9 An internal standard for the quantification of tebuconazole Tebuconazole-d9 Chemical Structure
  96. GC40341 Tetrahydro-11-deoxy Cortisol Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Tetrahydro-11-deoxy Cortisol Chemical Structure
  97. GC33833 Tetrahydrocurcumin (HZIV 81-2) Tetrahydrocurcumin (HZIV 81-2) is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin (HZIV 81-2) Chemical Structure
  98. GC40258 Tetrahydropiperine Tetrahydropiperine is a derivative of piperine and an arylpentanamide originally isolated from P. Tetrahydropiperine Chemical Structure
  99. GC45023 tetranor-12(R)-HETE Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through β-oxidation from C-1. tetranor-12(R)-HETE Chemical Structure
  100. GC15244 Thienyldecyl Isothiocyanate cytochrome P450 inhibitor Thienyldecyl Isothiocyanate Chemical Structure
  101. GC49503 Thujopsene A sesquiterpene with diverse biological activities Thujopsene Chemical Structure

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