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Home >> Signaling Pathways >> Apoptosis >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for  Caspase

  1. Cat.No. Product Name Information
  2. GC66048 δ-Secretase inhibitor 11 δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research. δ-Secretase inhibitor 11 Chemical Structure
  3. GC73585 (Rac)-M826 (Rac)-M826 is the racemate of M826. (Rac)-M826 Chemical Structure
  4. GC11988 15-acetoxy Scirpenol

    4-Deacetylanguidin,NSC 267030

     mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol Chemical Structure
  5. GC12545 2-HBA

    Bis(2-hydroxybenzylidene)acetone

     indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. 2-HBA Chemical Structure
  6. GC74668 3-Methoxy-9H-Carbazole 3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species. 3-Methoxy-9H-Carbazole Chemical Structure
  7. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone Chemical Structure
  8. GC17602 Ac-DEVD-AFC

    N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Trifluoromethylcoumarin,Caspase-3 Substrate (Fluorogenic)

     fluorogenic substrate for activated caspase-3 Ac-DEVD-AFC Chemical Structure
  9. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO is a Caspase-3 inhibitor with an IC50 value of 0.016μM. Ac-DEVD-CHO Chemical Structure
  10. GC10951 Ac-DEVD-CMK

    Ac-Asp-Glu-Val-Asp-CMK,Caspase-3 Inhibitor III

     cell-permeable, and irreversible inhibitor of caspase Ac-DEVD-CMK Chemical Structure
  11. GC68600 Ac-DEVD-CMK TFA

    Caspase-3 Inhibitor III TFA

    Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA is a selective and irreversible inhibitor of caspase-3. Ac-DEVD-CMK TFA significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate (IDB; 5). Ac-DEVD-CMK TFA can be used in various experimental methods to inhibit cell apoptosis.

     Ac-DEVD-CMK TFA Chemical Structure
  12. GC70289 AC-VEID-CHO TFA AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively. AC-VEID-CHO TFA Chemical Structure
  13. GC74380 Ac-VRPR-AMC TFA Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. Ac-VRPR-AMC TFA Chemical Structure
  14. GC68621 Ac-WEHD-AFC TFA

    Ac-WEHD-AFC TFA is a fluorescent substrate for caspase-1. It can detect the fluorescence activity of caspase-1 and is used in research on tumors and inflammation.

     Ac-WEHD-AFC TFA Chemical Structure
  15. GC73642 ALK-IN-26 ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 Chemical Structure
  16. GC35388 Aristolactam I Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristolactam I Chemical Structure
  17. GC35395 Arnicolide D

    ARD

     Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  18. GC72803 Aspidin BB Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB Chemical Structure
  19. GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK . Biotin-VAD-FMK Chemical Structure
  20. GC68787 Boc-Asp(OMe)-fluoromethyl ketone

    Boc-Asp(OMe)-FMK

    Boc-Asp(OME)-Fluoromethyl Keton is a widely used caspase inhibitor that can inhibit Fas-mediated phagocytosis and oxidative burst inhibition, but does not affect the chemotactic activity of IL-8.

     Boc-Asp(OMe)-fluoromethyl ketone Chemical Structure
  21. GC73417 CASP8-IN-1 CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 (CASP8), with an IC50 of 0.7 μM. CASP8-IN-1 Chemical Structure
  22. GC31886 Chelidonic acid

    NSC 3979

     A pyran with diverse biological activities Chelidonic acid Chemical Structure
  23. GC11908 Cisplatin

    CDDP

     Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers. Cisplatin Chemical Structure
  24. GC71214 CZL55 CZL55 is a caspase-1 inhibitor with an IC50 value of 24 nM. CZL55 Chemical Structure
  25. GC38452 Dehydrotrametenolic acid Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid Chemical Structure
  26. GC10661 Destruxin B

    SB 242536,NSC 236580

     insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  27. GC35908 Duocarmycin A Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels. Duocarmycin A Chemical Structure
  28. GC35980 Emricasan

    IDN-6556, PF-03491390

     A pan-caspase inhibitor Emricasan Chemical Structure
  29. GC31390 EP1013 (F1013)

    F1013

     EP1013 (F1013) (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. EP1013 (F1013) Chemical Structure
  30. GC74252 Euphornin Euphornin is a anticaner agent, that can be isolated from E. helioscopia. Euphornin Chemical Structure
  31. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 Chemical Structure
  32. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  33. GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine Chemical Structure
  34. GC73619 M190S

    M190S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo.

     M190S Chemical Structure
  35. GC72147 Mca-YVADAP-Lys(Dnp)-OH TFA Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2). Mca-YVADAP-Lys(Dnp)-OH TFA Chemical Structure
  36. GC33309 ML132 (NCGC 00185682)

    NCGC-00183434

     ML132 (NCGC 00185682) (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM. ML132 (NCGC 00185682) Chemical Structure
  37. GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. MPT0B392 Chemical Structure
  38. GC73137 Nenocorilant Nenocorilantis a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant Chemical Structure
  39. GC44409 Nivalenol

    NSC 269143

     Nivalenol is a type B trichothecene mycotoxin produced by Fusarium that is commonly found in contaminated foods. Nivalenol Chemical Structure
  40. GC12639 NS3694

    Apoptosis Inhibitor II

     inhibits apoptosome formation and caspase activation NS3694 Chemical Structure
  41. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  42. GC73272 PARP-1-IN-3 PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 Chemical Structure
  43. GC15880 Penicillic Acid

    NSC 402844

     mycotoxin Penicillic Acid Chemical Structure
  44. GC38064 PETCM PETCM Chemical Structure
  45. GC36895 Phenoxodiol

    Haginin E, Phenoxodiol

     Phenoxodiol is an isoflavone derivative with antitumor activity. Phenoxodiol Chemical Structure
  46. GC65474 QM31

    SVT016426

     QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. QM31 Chemical Structure
  47. GC72994 RAPTA-C

    Ru(Η6-p-cymene)Cl2(pta

     RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C Chemical Structure
  48. GC63914 Raptinal Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9. Raptinal Chemical Structure
  49. GC15267 Se-Aspirin

    Selenium-acetylsalicylic Acid

     nonsteroidal anti-inflammatory drug Se-Aspirin Chemical Structure
  50. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  51. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)

    Taurochenodeoxycholate, TCDCA

     Taurochenodeoxycholic acid (12-Deoxycholyltaurine) (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Chemical Structure
  52. GC37745 Taurodeoxycholic acid sodium hydrate

    Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

     Taurodeoxycholic acid sodium hydrate Chemical Structure
  53. GC34181 Tauroursodeoxycholate (TUDCA)

    3α,7β-dihydroxy-5β-cholanoyl Taurine, TUDCA, UR-906

     Tauroursodeoxycholate (TUDCA) is a cytoprotective agent in a variety of cells including hepatocytes as well as an inducer of apoptosis in cancer cells[1]. Tauroursodeoxycholate (TUDCA) Chemical Structure
  54. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate Chemical Structure
  55. GC73374 TD1092 TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 Chemical Structure
  56. GC10978 Terfenadine

    MDL 9918, NSC 665802, (±)-Terfenadine, DL-Terfenadine

     Histamine H1-receptor antagonist Terfenadine Chemical Structure
  57. GC37780 Thevetiaflavone Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. Thevetiaflavone Chemical Structure
  58. GC73760 Trilexium

    TRX-E-009-1

     Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1. Trilexium Chemical Structure
  59. GC12223 Z-Asp-CH2-DCB

    Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone

     caspase inhibitor Z-Asp-CH2-DCB Chemical Structure
  60. GC66403 Z-DEVD-AMC Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates. Z-DEVD-AMC Chemical Structure
  61. GC12407 Z-IETD-FMK

    Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone, Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

     Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell-permeable inhibitor of caspase-8. Z-IETD-FMK Chemical Structure
  62. GC16990 Z-LEHD-FMK Irreversible Caspase-9 inhibitor. Z-LEHD-FMK Chemical Structure
  63. GC26092 Z-LEHD-FMK TFA

    Caspase-9 Inhibitor

     Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. Z-LEHD-FMK TFA Chemical Structure
  64. GC72985 Z-LEVD-FMK Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK Chemical Structure
  65. GC12861 Z-VAD-FMK

    Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK

     Z-VAD-FMK (Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone), an ICE-like protease inhibitor, inhibits apoptosis by preventing the processing of CPP32 to its active form. [3] Z-VAD-FMK Chemical Structure
  66. GC14188 Z-YVAD-FMK Caspase-1 inhibitor Z-YVAD-FMK Chemical Structure
  67. GC37974 ZYZ-488 ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3. ZYZ-488 Chemical Structure

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