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Home >> Signaling Pathways >> Apoptosis >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for  Caspase

  1. Cat.No. Product Name Information
  2. GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol Chemical Structure
  3. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. 2-HBA Chemical Structure
  4. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist 5,7-dihydroxychromone Chemical Structure
  5. GC17602 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3 Ac-DEVD-AFC Chemical Structure
  6. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO Chemical Structure
  7. GC10951 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase Ac-DEVD-CMK Chemical Structure
  8. GC10258 Ac-IEPD-AFC Recognition motif for serine protease granzyme B Ac-IEPD-AFC Chemical Structure
  9. GC10968 Ac-LEHD-AFC Fluorogenic caspase substrate Ac-LEHD-AFC Chemical Structure
  10. GC14209 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable Apoptosis Activator 2 Chemical Structure
  11. GC10160 Apoptosis Inhibitor

    Associate with caspase-3 inhibition

     Apoptosis Inhibitor Chemical Structure
  12. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide AZ 10417808 Chemical Structure
  13. GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK . Biotin-VAD-FMK Chemical Structure
  14. GC16774 Boc-D-FMK Pan-caspase inhibitor Boc-D-FMK Chemical Structure
  15. GC11718 Caspase-3/7 Inhibitor I Caspase-3/7 inhibitor Caspase-3/7 Inhibitor I Chemical Structure
  16. GC31886 Chelidonic acid Chelidonic acid Chemical Structure
  17. GC11908 Cisplatin

    Inhibits DNA synthesis,chemotherapy drug

     Cisplatin Chemical Structure
  18. GN10040 Dehydrocorydaline Extracted from Corydalis yanhusuo W.T. Wang dried rhizome;Store the product in sealed, cool and dry condition Dehydrocorydaline Chemical Structure
  19. GC38452 Dehydrotrametenolic acid Dehydrotrametenolic acid Chemical Structure
  20. GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  21. GN10564 Ecdysterone Ecdysteroid hormone,naturally occurring Ecdysterone Chemical Structure
  22. GC35980 Emricasan Emricasan Chemical Structure
  23. GC31390 EP1013 (F1013) EP1013 (F1013) Chemical Structure
  24. GC12139 Gambogic Acid Caspase activator and apoptosis inducer Gambogic Acid Chemical Structure
  25. GN10686 Ginsenoside Rh2 Extracted from Panax ginseng C. A. Mey.;Store the product in sealed,cool and dry condition Ginsenoside Rh2 Chemical Structure
  26. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 Chemical Structure
  27. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  28. GC18137 Ivachtin Caspase-3 inhibitor Ivachtin Chemical Structure
  29. GC33309 ML132 (NCGC 00185682) ML132 (NCGC 00185682) Chemical Structure
  30. GC44409 Nivalenol Nivalenol is a type B trichothecene mycotoxin produced by Fusarium that is commonly found in contaminated foods. Nivalenol Chemical Structure
  31. GC12639 NS3694 inhibits apoptosome formation and caspase activation NS3694 Chemical Structure
  32. GC11993 PAC-1

    Procaspase-3 activator

     PAC-1 Chemical Structure
  33. GC15880 Penicillic Acid mycotoxin Penicillic Acid Chemical Structure
  34. GC38064 PETCM PETCM Chemical Structure
  35. GC14886 PETCM Caspase-3 activator PETCM Chemical Structure
  36. GC36895 Phenoxodiol Phenoxodiol Chemical Structure
  37. GC11713 Q-VD(OMe)-OPh Pan-caspase inhibitor Q-VD(OMe)-OPh Chemical Structure
  38. GC16316 Q-VD-OPh hydrate Cell-permeable, irreversible pan-caspase inhibitor Q-VD-OPh hydrate Chemical Structure
  39. GC63914 Raptinal Raptinal Chemical Structure
  40. GC15267 Se-Aspirin nonsteroidal anti-inflammatory drug Se-Aspirin Chemical Structure
  41. GN10801 Senkyunolide I Extracted from Ligusticumchuanxiong Hort. rhizome;Store the product in sealed, cool and dry condition Senkyunolide I Chemical Structure
  42. GC17425 Sodium Tauroursodeoxycholate (TUDC) water soluble bile salt Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  43. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) One of main bioactive substances of animals' bile acid Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Chemical Structure
  44. GC37745 Taurodeoxychloic Acid sodium hydrate Taurodeoxychloic Acid sodium hydrate Chemical Structure
  45. GC34181 Tauroursodeoxycholate (TUDCA) An endoplasmic reticulum (ER) stress inhibitor Tauroursodeoxycholate (TUDCA) Chemical Structure
  46. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate dihydrate Chemical Structure
  47. GC10978 Terfenadine Histamine H1-receptor antagonist Terfenadine Chemical Structure
  48. GC37780 Thevetiaflavone Thevetiaflavone Chemical Structure
  49. GC12725 VX-765

    A potent and selective caspase-1 inhibitor

     VX-765 Chemical Structure
  50. GN10269 Wedelolactone IKK inhibitor Wedelolactone Chemical Structure
  51. GC12223 Z-Asp-CH2-DCB caspase inhibitor Z-Asp-CH2-DCB Chemical Structure
  52. GC12287 Z-DEVD-FMK Caspase-3 inhibitor Z-DEVD-FMK Chemical Structure
  53. GC16744 Z-DQMD-FMK Caspase-3 inhibitor,cell-permeable Z-DQMD-FMK Chemical Structure
  54. GC15066 Z-FA-FMK Cysteine proteases inhibitor Z-FA-FMK Chemical Structure
  55. GC12407 Z-IETD-FMK Caspase-8 inhibitor Z-IETD-FMK Chemical Structure
  56. GC16990 Z-LEHD-FMK Irreversible Caspase-9 inhibitor. Z-LEHD-FMK Chemical Structure
  57. GC12861 Z-VAD-FMK

    Cell-permeable, irreversible pan-caspase inhibitor

     Z-VAD-FMK Chemical Structure
  58. GC11218 Z-VDVAD-FMK Caspase-2 inhibitor Z-VDVAD-FMK Chemical Structure
  59. GC13413 Z-VEID-FMK Caspase-6 inhibitor Z-VEID-FMK Chemical Structure
  60. GC12190 Z-WEHD-FMK

    Caspase 5 inhibitor,potent,cell-permeable and irreversible

     Z-WEHD-FMK Chemical Structure
  61. GC14188 Z-YVAD-FMK Caspase-1 inhibitor Z-YVAD-FMK Chemical Structure
  62. GC37974 ZYZ-488 ZYZ-488 Chemical Structure

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