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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis

Products for  Other Apoptosis

  1. Cat.No. Product Name Information
  2. GC11837 MI-136 menin-MLL interaction inhibitor MI-136 Chemical Structure
  3. GC11418 MI-2 An inhibitor of menin-MLL fusion protein interactions MI-2 Chemical Structure
  4. GC12199 MI-3 An inhibitor of menin-MLL fusion protein interactions MI-3 Chemical Structure
  5. GC38817 Minerval Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect. Minerval Chemical Structure
  6. GC36612 Minnelide Minnelide is a prodrug of triptolide that shows potent antitumor activity in a number of tumor types, particularly in pancreatic cancer. Minnelide promotes apoptosis. Minnelide Chemical Structure
  7. GC36613 Minodronic acid Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain. Minodronic acid Chemical Structure
  8. GC32929 MIR96-IN-1 MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively. MIR96-IN-1 Chemical Structure
  9. GC36619 MitoTam bromide, hydrobromide MitoTam bromide, hydrobromide, a Tamoxifen derivative, is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology. MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells. MitoTam bromide, hydrobromide Chemical Structure
  10. GC36620 MitoTam iodide, hydriodide MitoTam iodide, hydriodide is a Tamoxifen derivative, an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology.MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells. MitoTam iodide, hydriodide causes apoptosis. MitoTam iodide, hydriodide Chemical Structure
  11. GC16976 Mitotane (Lsodren) Mitotane (Lsodren) (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane (Lsodren) exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane (Lsodren) can have direct pituitary effects on corticotroph cells. Mitotane (Lsodren) can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has drug-drug interactions. Mitotane (Lsodren) Chemical Structure
  12. GC19248 Mivebresib Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib Chemical Structure
  13. GC13630 MK-4101 Hedgehog (Hh) signaling pathway inhibitor MK-4101 Chemical Structure
  14. GC17802 MK-4827 An orally bioavailable PARP1/2 inhibitor MK-4827 Chemical Structure
  15. GC12756 MK-4827 hydrochloride MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. MK-4827 hydrochloride Chemical Structure
  16. GC11537 MK-4827 tosylate MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity. MK-4827 tosylate Chemical Structure
  17. GC10442 MK-8745 Aurora A inhibitor,potent and selective MK-8745 Chemical Structure
  18. GC14800 ML 141 Cdc42 GTPase inhibitor ML 141 Chemical Structure
  19. GC12690 MLN8237 (Alisertib)

    An Aurora A kinase inhibitor

     MLN8237 (Alisertib) Chemical Structure
  20. GC38406 MN58b MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity. MN58b Chemical Structure
  21. GC13055 Mocetinostat (MGCD0103, MG0103) An orally available HDAC inhibitor Mocetinostat (MGCD0103, MG0103) Chemical Structure
  22. GC11655 Moexipril HCl Moexipril HCl (RS-10085) is an orally active inhibitor of angiotensin-converting enzyme (ACE), and becomes effective by being hydrolyzed to moexiprila (hydrochloride). Moexipril HCl Chemical Structure
  23. GC14929 Monastrol

    Eg5 inhibitor

     Monastrol Chemical Structure
  24. GC17276 Monomethyl auristatin E

    A potent antimitotic compound

     Monomethyl auristatin E Chemical Structure
  25. GN10360 Morroniside Morroniside Chemical Structure
  26. GC10083 MPI-0479605 Mps1 inhibitor,selective and ATP competitive MPI-0479605 Chemical Structure
  27. GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. MPT0B392 Chemical Structure
  28. GC11097 MPTP hydrochloride

    MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxic agent that is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.

     MPTP hydrochloride Chemical Structure
  29. GC11078 MRS 2578 P2Y6 receptor antagonist,potent and selective MRS 2578 Chemical Structure
  30. GC50223 MSC 2032964A Potent and selective ASK1 inhibitor; orally bioavailable MSC 2032964A Chemical Structure
  31. GC13614 Mycophenolate Mofetil A prodrug form of mycophenolic acid Mycophenolate Mofetil Chemical Structure
  32. GC17121 Mycophenolic acid Dehydrogenase inhibitor Mycophenolic acid Chemical Structure
  33. GN10634 Myricetin Myricetin Chemical Structure
  34. GC10613 Nafamostat Mesylate(FUT-175) A serine protease inhibitor Nafamostat Mesylate(FUT-175) Chemical Structure
  35. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3 Chemical Structure
  36. GC50112 NCL 00017509 NCL 00017509 (compound 6) is a potent and irreversible Nek2 ((Never in mitosis gene a)-related kinase 2) inhibitior. NCL 00017509 Chemical Structure
  37. GC13906 Nebivolol hydrochloride Highly selective β1-adrenoceptor antagonist Nebivolol hydrochloride Chemical Structure
  38. GC10150 Necrosulfonamide

    Necrosulfonamide (NSA) is a specific inhibitor of MLKL (mixed lineage kinase domain-like protein)[1].

     Necrosulfonamide Chemical Structure
  39. GN10103 Neferine Neferine Chemical Structure
  40. GC10591 Nelarabine Prodrug of ara-G for T-LBL/T-ALL Nelarabine Chemical Structure
  41. GC30085 Neobavaisoflavone A natural isoflavone Neobavaisoflavone Chemical Structure
  42. GC40669 Nerol Nerol is a monoterpene and isomer of geraniol that has been found in a variety of plants, including Cannabis. Nerol Chemical Structure
  43. GC36743 Nimustine hydrochloride Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas. Nimustine hydrochloride Chemical Structure
  44. GC36747 Nitroaspirin Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins. Nitroaspirin Chemical Structure
  45. GC44409 Nivalenol Nivalenol is a type B trichothecene mycotoxin produced by Fusarium that is commonly found in contaminated foods. Nivalenol Chemical Structure
  46. GC19263 NKP-1339 NKP-1339(IT-139) is a ruthenium(iii) coordination anticancer compound based on target to transferrin. NKP-1339 Chemical Structure
  47. GC12515 NMS-1286937 NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM. NMS-1286937 Chemical Structure
  48. GN10325 Nobiletin Nobiletin Chemical Structure
  49. GC14075 Nocodazole A tubulin production inhibitor,anti-neoplastic agent Nocodazole Chemical Structure
  50. GC12090 Nonactin

    Monovalent cation ionophore that displays selectivity for K+ and NH4+

     Nonactin Chemical Structure
  51. GC10628 nor-NOHA (acetate) nor-NOHA (acetate) (alpha-amino acid N(omega) -Hydroxy-Nor-L-arginine) is a potent and reversible selective arginase inhibitor, nor-NOHA (acetate) Chemical Structure
  52. GC11989 Nortriptyline (hydrochloride) norepinephrine and serotonin transporters blocker Nortriptyline (hydrochloride) Chemical Structure
  53. GC14488 NPS-1034 MET inhibitor NPS-1034 Chemical Structure
  54. GC17577 NQDI 1 A selective inhibitor of ASK1 NQDI 1 Chemical Structure
  55. GC10069 NSC 23766 trihydrochloride Selective inhibitor of Rac1-GEF interaction. NSC 23766 trihydrochloride Chemical Structure
  56. GC11561 NSC 95397 Cdc25 dual specificity phosphatases inhibitor NSC 95397 Chemical Structure
  57. GC16151 NSC348884 nucleophosmin inhibitor NSC348884 Chemical Structure
  58. GC12332 NU 7026 DNPK inhibitor,ATP-competitive and potent NU 7026 Chemical Structure
  59. GC10470 Nutlin-3a chiral An inhibitor of the p53-Mdm2 interaction Nutlin-3a chiral Chemical Structure
  60. GC16145 NVP-BGT226 BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. NVP-BGT226 Chemical Structure
  61. GC17555 NVP-TNKS656 TNKS2 inhibitor NVP-TNKS656 Chemical Structure
  62. GN10776 Obacunone Obacunone Chemical Structure
  63. GN10144 Oleandrin Oleandrin Chemical Structure
  64. GC30110 Oleic acid (9-cis-Octadecenoic acid) Oleic acid (9-cis-Octadecenoic acid) (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid (9-cis-Octadecenoic acid) Chemical Structure
  65. GN10457 Oleuropein

    A polyphenol

     Oleuropein Chemical Structure
  66. GC16409 Oligomycin B mitochondrial F1FO ATP synthase inhibitor Oligomycin B Chemical Structure
  67. GC13693 Omaveloxolone (RTA-408) Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone (RTA-408) Chemical Structure
  68. GC34095 ONC212 A GPR132 agonist ONC212 Chemical Structure
  69. GC14860 Oncrasin 1 An anticancer agent Oncrasin 1 Chemical Structure
  70. GC13219 ONO-4059 ONO-4059 is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor. ONO-4059 Chemical Structure
  71. GC17318 Orlistat Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach. Orlistat Chemical Structure
  72. GC11528 Orotic acid Pyrimidinecarboxylic acid Orotic acid Chemical Structure
  73. GN10732 Oroxin B Oroxin B Chemical Structure
  74. GC31596 Osajin (CID 95168) Osajin (CID 95168) is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities. Osajin (CID 95168) Chemical Structure
  75. GC14957 OSI-930 Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck OSI-930 Chemical Structure
  76. GN10333 Osthole Osthole Chemical Structure
  77. GC36821 OSU-T315 OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner. OSU-T315 causes cell death through apoptosis and autophagy. OSU-T315 Chemical Structure
  78. GC25691 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis. OTS514 hydrochloride Chemical Structure
  79. GC16511 OTS964 OTS964 is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM. OTS964 Chemical Structure
  80. GC12011 P276-00 P276-00 (P276-00) is a potent cyclin-dependent kinase (CDK) inhibitor, which inhibits CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively.P276-00 (P276-00) shows antitumor activity on cisplatin-resistant cells. P276-00 Chemical Structure
  81. GC11993 PAC-1 An in vitro procaspase-3 activator PAC-1 Chemical Structure
  82. GC12773 Palomid 529

    PI3K/Akt/mTOR inhibitor

     Palomid 529 Chemical Structure
  83. GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor Panobinostat (LBH589) Chemical Structure
  84. GC12718 Pantoprazole H+/K+-ATPase inhibitor Pantoprazole Chemical Structure
  85. GC36847 Pantoprazole sodium Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium Chemical Structure
  86. GC36848 Pantoprazole sodium hydrate Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate Chemical Structure
  87. GN10357 Parthenolide Parthenolide Chemical Structure
  88. GC40483 Patulin

    Patulin is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.

     Patulin Chemical Structure
  89. GC33002 PBOX 6 PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. PBOX 6 Chemical Structure
  90. GC18008 PCI-34051 A potent, selective HDAC8 inhibitor PCI-34051 Chemical Structure
  91. GC15142 PD-1/PD-L1 inhibitor 1 (BMS-1) PD-1/PD-L1 inhibitor 1 (BMS-1) is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM). PD-1/PD-L1 inhibitor 1 (BMS-1) Chemical Structure
  92. GC16762 PD-1/PD-L1 inhibitor 2 PD-1/PD-L1 inhibitor 2 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. PD-1/PD-L1 inhibitor 2 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. PD-1/PD-L1 inhibitor 2 has antitumor activity. PD-1/PD-L1 inhibitor 2 Chemical Structure
  93. GC32853 PD0166285 PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1. PD0166285 Chemical Structure
  94. GC10397 PD0325901

    A MEK inhibitor that sustains stem cell renewal

     PD0325901 Chemical Structure
  95. GC11015 PD168393 EGFR inhibitor PD168393 Chemical Structure
  96. GC13592 PD173955 Dual Src/Abl kinase inhibitor, ATP-competitive, PD173955 Chemical Structure
  97. GC12989 PD184352 (CI-1040) PD184352 (CI-1040) (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. PD184352 (CI-1040) Chemical Structure
  98. GC36865 PEAQX tetrasodium hydrate PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate Chemical Structure
  99. GC11610 Pemetrexed An antifolate with anticancer activity Pemetrexed Chemical Structure
  100. GC17694 Pemetrexed disodium hemipenta hydrate Pemetrexed disodium hemipenta hydrate Chemical Structure
  101. GC15880 Penicillic Acid mycotoxin Penicillic Acid Chemical Structure

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