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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis

Products for  Other Apoptosis

  1. Cat.No. Product Name Information
  2. GC14503 IC261 CK1 inhibitor IC261 Chemical Structure
  3. GC38096 Icaritin Icaritin is a prenylflavonoid derivative obtained from the Epimedium genus. Icaritin Chemical Structure
  4. GC19198 iCRT3 iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. iCRT3 Chemical Structure
  5. GC19411 IITZ-01 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. IITZ-01 Chemical Structure
  6. GC38566 Ilexsaponin A Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A Chemical Structure
  7. GC19199 Importazole Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β. Importazole Chemical Structure
  8. GC19200 INCB-057643 INCB-057643 is a novel, orally bioavailable BET inhibitor. INCB-057643 Chemical Structure
  9. GC17866 INCB28060 INCB28060 (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). INCB28060 can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. INCB28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. INCB28060 is largely metabolized by CYP3A4 and aldehyde oxidase. INCB28060 Chemical Structure
  10. GC38213 Incensole Acetate Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole Acetate Chemical Structure
  11. GC36308 Indibulin An inhibitor of microtubule assembly Indibulin Chemical Structure
  12. GC12975 Indirubin A cyclin-dependent kinases and GSK-3β inhibitor Indirubin Chemical Structure
  13. GC10334 INH6 Hec1/Nek2 inhibitor, potent INH6 Chemical Structure
  14. GC15148 Ionomycin calcium salt

    Lonomycin is a selective calcium ionophore derived from S. conglobatus that mobilizes intracellular calcium stores.

     Ionomycin calcium salt Chemical Structure
  15. GC15446 Ionomycin free acid Ionomycin free acid (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin free acid Chemical Structure
  16. GC46027 IP7e An activator of Nurr1 signaling IP7e Chemical Structure
  17. GC10467 Irbesartan Angiotensin II inhibitor Irbesartan Chemical Structure
  18. GC12962 Isatin endogenous monoamine oxidase inhibitor Isatin Chemical Structure
  19. GN10666 Isoalantolactone Isoalantolactone Chemical Structure
  20. GC13795 Isobavachalcone A chalcone and flavonoid with diverse biological activities Isobavachalcone Chemical Structure
  21. GC38220 Isoliensinine Isoliensinine Chemical Structure
  22. GN10088 Isoliquiritigenin Isoliquiritigenin Chemical Structure
  23. GC36343 Isosilybin A Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis. Isosilybin A Chemical Structure
  24. GC36344 Isosilybin B Isosilybin B, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation. Isosilybin B Chemical Structure
  25. GC13394 Ispinesib (SB-715992) Ispinesib (SB-715992) is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM. Ispinesib (SB-715992) Chemical Structure
  26. GC16869 Ixabepilone A broad-spectrum anticancer agent Ixabepilone Chemical Structure
  27. GN10645 Jaceosidin Jaceosidin Chemical Structure
  28. GC34634 JG-98 JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. JG-98 Chemical Structure
  29. GC15603 JIB-04 Jumonji histone demethylase inihibitor JIB-04 Chemical Structure
  30. GC12117 JNJ-26854165 (Serdemetan) An antagonist of MDM2 action JNJ-26854165 (Serdemetan) Chemical Structure
  31. GC12612 JNJ-7706621 A dual inhibitor of CDKs and Aurora kinases JNJ-7706621 Chemical Structure
  32. GC38082 JTE-013 A selective S1P2 receptor antagonist JTE-013 Chemical Structure
  33. GC16167 K 858 K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM. K 858 Chemical Structure
  34. GC15281 K-252c Protein kinase inhibitor K-252c Chemical Structure
  35. GC12247 K-Ras(G12C) inhibitor 12 allosteric inhibitor of K-Ras(G12C) K-Ras(G12C) inhibitor 12 Chemical Structure
  36. GC38209 Kahweol A natural diterpene with antiinflammatory and antiangiogenic properties Kahweol Chemical Structure
  37. GC13339 Ketoprofen Dual COX1/2 inhibitor Ketoprofen Chemical Structure
  38. GC36393 Kinetin riboside Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM. Kinetin riboside Chemical Structure
  39. GC16922 Kobe0065 Ras inhibitor Kobe0065 Chemical Structure
  40. GC19215 KRIBB11 KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 uM. KRIBB11 Chemical Structure
  41. GC17346 KT 5823 A protein kinase G inhibitor KT 5823 Chemical Structure
  42. GC14592 KW 2449 A multi-kinase inhibitor KW 2449 Chemical Structure
  43. GC15364 L-685,458 A γ-secretase inhibitor L-685,458 Chemical Structure
  44. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid monosodium salt (Monosodium glutamate) Chemical Structure
  45. GC30266 L-SelenoMethionine A naturally occurring amino acid with antioxidant properties L-SelenoMethionine Chemical Structure
  46. GN10456 L-Theanine L-Theanine Chemical Structure
  47. GC15550 Lacidipine L-type calcium channel blocker Lacidipine Chemical Structure
  48. GC10474 Laquinimod (ABR-215062) Laquinimod (ABR-215062) (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod (ABR-215062) Chemical Structure
  49. GC36424 Larotaxel Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel. Larotaxel Chemical Structure
  50. GC11784 LCZ696 LCZ696 (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure. LCZ696 Chemical Structure
  51. GC17067 LDC000067 CDK9 inhibitor, novel and highly specific LDC000067 Chemical Structure
  52. GC10510 LDN 57444 An inhibitor of UCH-L1 LDN 57444 Chemical Structure
  53. GC36434 Leachianone A Leachianone A, isolated from Radix Sophorae, has anti-malarial, anti-inflammatory, and cytotoxic potent. Leachianone A Chemical Structure
  54. GC14976 Lenalidomide (CC-5013) An analog of thalidomide Lenalidomide (CC-5013) Chemical Structure
  55. GC38196 Licofelone A dual inhibitor of COX1/COX2 and 5LO Licofelone Chemical Structure
  56. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin Chemical Structure
  57. GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride) Lidocaine hydrochloride (Lignocaine hydrochloride) (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride (Lignocaine hydrochloride) Chemical Structure
  58. GC16589 Limonin

    A limonoid

     Limonin Chemical Structure
  59. GN10122 Linalool Linalool Chemical Structure
  60. GC38086 Linderalactone Linderalactone Chemical Structure
  61. GC17958 Linifanib (ABT-869) Linifanib (ABT-869) (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (ABT-869) shows prominent antitumor activity. Linifanib (ABT-869) has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib (ABT-869) is a specific miR-10b inhibitor that blocks miR-10b biogenesis. Linifanib (ABT-869) Chemical Structure
  62. GC17057 Lithocholic Acid Activator of vitamin D receptor,PXR and FXR Lithocholic Acid Chemical Structure
  63. GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor LJH685 Chemical Structure
  64. GN10405 Loganin Loganin Chemical Structure
  65. GC18404 Lometrexol Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol Chemical Structure
  66. GC17865 Lomustine Antineoplastic drug Lomustine Chemical Structure
  67. GC11532 Lonidamine hexokinase inactivator Lonidamine Chemical Structure
  68. GC15282 LOXO-101 (Larotrectinib) sulfate LOXO-101 (Larotrectinib) sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). LOXO-101 (Larotrectinib) sulfate Chemical Structure
  69. GC10809 LRRK2-IN-1 A selective LRRK2 inhibitor LRRK2-IN-1 Chemical Structure
  70. GC36488 Lucidenic acid B Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells. Lucidenic acid B Chemical Structure
  71. GN10142 Lupeol Lupeol Chemical Structure
  72. GN10370 Luteolin Luteolin Chemical Structure
  73. GC32724 LW6 (HIF-1α inhibitor) LW6 (HIF-1α inhibitor) (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 of 4.4 μM. LW6 (HIF-1α inhibitor) decreases HIF-1α protein expression without affecting HIF-1β expression. LW6 (HIF-1α inhibitor) Chemical Structure
  74. GC12191 LY-411575 A γ-secretase inhibitor LY-411575 Chemical Structure
  75. GC16835 LY2228820 LY2228820 (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. LY2228820 Chemical Structure
  76. GC10093 LY2409881 LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM. LY2409881 Chemical Structure
  77. GC11971 LY2857785 CDK9 inhibitor LY2857785 Chemical Structure
  78. GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine Chemical Structure
  79. GC17785 Macitentan Endothelin (ET)(A) and ET(B) receptor antagonist Macitentan Chemical Structure
  80. GC45723 Macitentan-d4 An internal standard for the quantification of macitentan Macitentan-d4 Chemical Structure
  81. GN10173 Madecassoside Madecassoside Chemical Structure
  82. GN10491 Mangiferin Mangiferin Chemical Structure
  83. GC10265 Manumycin A

    farnesyltransferase inhibitor

     Manumycin A Chemical Structure
  84. GC36542 MARK4 inhibitor 1 MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 Chemical Structure
  85. GC36546 Masitinib mesylate Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity. Masitinib mesylate Chemical Structure
  86. GC32895 Maytansinol (Ansamitocin P-0) Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and induces microtubule disassembly in vitro. Maytansinol (Ansamitocin P-0) Chemical Structure
  87. GC36552 MBM-17 MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice. MBM-17 Chemical Structure
  88. GC36553 MBM-55 MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice. MBM-55 Chemical Structure
  89. GC10200 Mdivi 1

    A mitochondrial division inhibitor

     Mdivi 1 Chemical Structure
  90. GC17649 Mebendazole broad-spectrum anthelmintic that inhibits intestinal microtubule synthesis Mebendazole Chemical Structure
  91. GC14312 Meisoindigo Apoptosis inducer;potential agent for AML Meisoindigo Chemical Structure
  92. GC11762 Meloxicam (Mobic) Meloxicam (Mobic) is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively. Meloxicam (Mobic) Chemical Structure
  93. GC12393 Melphalan DNA alkylating agent Melphalan Chemical Structure
  94. GC10405 Methotrexate

    Methotrexate, a folate antagonist, is a potent anti-inflammatory agent when used weekly in low concentrations, the anti-phlogistic action of which is due to increased adenosine release at inflamed sites. 

     Methotrexate Chemical Structure
  95. GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Chemical Structure
  96. GN10639 Methyl protodioscin Methyl protodioscin Chemical Structure
  97. GC15775 Metronidazole

    nitroimidazole antibiotic

     Metronidazole Chemical Structure
  98. GC11895 Mevastatin HMG-CoA reductase inhibitor Mevastatin Chemical Structure
  99. GC11439 MG 149 HAT inhibitor MG 149 Chemical Structure
  100. GC13598 MGCD-265 MGCD-265 is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50s of 29 nM and 10 nM, respectively. MGCD-265 has significant antitumor activity. MGCD-265 Chemical Structure
  101. GC36605 MI-1061 MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. MI-1061 Chemical Structure

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