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Home >> Signaling Pathways >> Apoptosis >> Other Apoptosis

Other Apoptosis

Products for  Other Apoptosis

  1. Cat.No. Product Name Information
  2. GC14644 SBE 13 HCl SBE 13 HCl is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE 13 HCl poorly inhibits Plk2 (IC50>66μM) or Plk3 (IC50=875nM). SBE 13 HCl Chemical Structure
  3. GC15654 SBI-0206965 ULK1 inhibitor SBI-0206965 Chemical Structure
  4. GC11985 SC 66

    Akt inhibitor

     SC 66 Chemical Structure
  5. GC14561 SCH 529074

    restores mutant p53 activity

     SCH 529074 Chemical Structure
  6. GC10291 SCH 79797 dihydrochloride PAR1 receptor antagonist SCH 79797 dihydrochloride Chemical Structure
  7. GN10005 Schisandrin C Schisandrin C Chemical Structure
  8. GC31699 Scopoletin (Gelseminic acid) Scopoletin (Gelseminic acid) is an inhibitor of acetylcholinesterase (AChE). Scopoletin (Gelseminic acid) Chemical Structure
  9. GC15315 Scriptaid HDAC inhibitor Scriptaid Chemical Structure
  10. GC38848 Se-Methylselenocysteine Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis. Se-Methylselenocysteine Chemical Structure
  11. GC13568 SecinH3

    Sec7-specific GEF inhibitor

     SecinH3 Chemical Structure
  12. GC12124 Selonsertib (GS-4997) Selonsertib (GS-4997) (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) Chemical Structure
  13. GC38653 Selumetinib sulfate Selumetinib (AZD6244) is selective, non-ATP-competitive oral?MEK1/2?inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib sulfate Chemical Structure
  14. GC34177 Sesamol A lignan with diverse biological activities Sesamol Chemical Structure
  15. GC37633 SF1126 SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor, has antitumor and anti-angiogenic activity. SF1126 is an RGDS-conjugated LY294002 prodrug, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment. SF1126 induces cell apoptosis. SF1126 Chemical Structure
  16. GC14364 SGI-1027 DNMT inhibitor SGI-1027 Chemical Structure
  17. GC16497 SGI-1776 free base A potent inhibitor of Pim kinases SGI-1776 free base Chemical Structure
  18. GC32973 SID 3712249 (MiR-544 Inhibitor 1) SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 (MiR-544 Inhibitor 1) binds directly to the precursor miRNA. SID 3712249 (MiR-544 Inhibitor 1) blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 (MiR-544 Inhibitor 1) can be used in the research of cancers, such as breast cancer. SID 3712249 (MiR-544 Inhibitor 1) Chemical Structure
  19. GC17685 Sildenafil Citrate A PDE5 inhibitor Sildenafil Citrate Chemical Structure
  20. GC11455 Silvestrol Silvestrol Chemical Structure
  21. GC10585 Simvastatin (Zocor) Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Simvastatin (Zocor) Chemical Structure
  22. GC31511 Sinapinic acid (Sinapic acid) Sinapinic acid (Sinapic acid) (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Sinapinic acid (Sinapic acid) Chemical Structure
  23. GN10213 Sinomenine Hydrochloride Sinomenine Hydrochloride Chemical Structure
  24. GC44892 Siomycin A The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A Chemical Structure
  25. GC11716 SIRT1/2 Inhibitor IV SIRT1/2 Inhibitor IV is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. SIRT1/2 Inhibitor IV is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). SIRT1/2 Inhibitor IV Chemical Structure
  26. GC14945 Sirtinol Inhibitor of sirtuin deacetylases Sirtinol Chemical Structure
  27. GC50372 SK 216 Plasminogen activator inhibitor-1 (PAI-1) inhibitor SK 216 Chemical Structure
  28. GC37646 SKF-86002 SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 Chemical Structure
  29. GC16701 SKI II Sphingosine kinase(SK) inhibitor SKI II Chemical Structure
  30. GC50141 SMBA 1 High affinity and selective activator of Bax SMBA 1 Chemical Structure
  31. GC16055 SMIP004 SMIP004 Chemical Structure
  32. GC11396 SNS-032 (BMS-387032) SNS-032 (BMS-387032) (BMS-387032) is a potent and selective inhibitor ofCDK2, CDK7, and CDK9 withIC50sof 38 nM, 62 nM and 4 nM, respectively. SNS-032 (BMS-387032) has antitumor effect. SNS-032 (BMS-387032) Chemical Structure
  33. GC13616 Sodium ascorbate Sodium ascorbate (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. Sodium ascorbate inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. Sodium ascorbate is also a collagen deposition enhancer and an elastogenesis inhibitor. Sodium ascorbate Chemical Structure
  34. GC15857 Sodium butyrate

    Histone deacetylase inhibitor

     Sodium butyrate Chemical Structure
  35. GC15002 Sodium Phenylbutyrate A chemical chaperone Sodium Phenylbutyrate Chemical Structure
  36. GC12013 Sodium salicylate

    NF-κB inhibitor

     Sodium salicylate Chemical Structure
  37. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  38. GN10681 Sophocarpine Sophocarpine Chemical Structure
  39. GC38425 Sophoridine A quinolizidine alkaloid with diverse biological activities Sophoridine Chemical Structure
  40. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

     Sorafenib Chemical Structure
  41. GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib Sorafenib (D3) Chemical Structure
  42. GC37665 Sorafenib (D4) Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4) Chemical Structure
  43. GC37668 Soyasapogenol A Soyasapogenol A, a triterpene compound, isolated from the roots of Abrus cantoniensis. Soyasapogenol A Chemical Structure
  44. GC37669 Soyasapogenol B Soyasapogenol B, an ingredient of soybean, exerts anti-proliferative, anti-metastatic activities. Soyasapogenol B triggers endoplasmic reticulum stress, which mediates apoptosis and autophagy in colorectal cancer. Soyasapogenol B Chemical Structure
  45. GC39182 Soyasaponin III Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells. Soyasaponin III Chemical Structure
  46. GC14631 SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific SP2509 Chemical Structure
  47. GC13526 Spautin-1 Novel autophagy inhibitor Spautin-1 Chemical Structure
  48. GC39175 SR-4835 SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death. SR-4835 Chemical Structure
  49. GC37678 SS28 SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin. SS28 Chemical Structure
  50. GC33074 SSE15206 SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. SSE15206 Chemical Structure
  51. GC37688 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. STAT3-IN-1 Chemical Structure
  52. GC17886 Stattic Stattic is the first non-peptide small molecule inhibitor of STAT3, which effectively inhibits STAT3 activation and nuclear translocation. Stattic Chemical Structure
  53. GC12830 Stavudine (d4T) Stavudine (d4T) (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine (d4T) Chemical Structure
  54. GC44953 Sterigmatocystin

    Sterigmatocystin is a mycotoxin produced by fungi of the genus Aspergillus[1].

     Sterigmatocystin Chemical Structure
  55. GC17096 STF-118804 NAMPT inhibitor STF-118804 Chemical Structure
  56. GC19771 STM2457

    A first-in-class, highly potent, selective and orally active METTL3 inhibitor

     STM2457 Chemical Structure
  57. GC15571 SU 9516 A pro-apoptotic Cdk2/cyclin A inhibitor SU 9516 Chemical Structure
  58. GC11089 SU11274 C-Met inhibitor,potent and selective SU11274 Chemical Structure
  59. GC16868 Sulfasalazine NF-κB activation inhibitor Sulfasalazine Chemical Structure
  60. GC17651 Sunitinib RTK inhibitor Sunitinib Chemical Structure
  61. GC11869 SZL P1-41 Skp2 inhibitor SZL P1-41 Chemical Structure
  62. GC44981 T-2 Toxin T-2 toxin is a common trichothecene mycotoxin produced by Fusarium species, which can infect grain crops causing alimentary toxic aleukia in humans and animals. T-2 Toxin Chemical Structure
  63. GC37715 Taccalonolide A Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells. Taccalonolide A Chemical Structure
  64. GC17074 Tadalafil A PDE5 inhibitor Tadalafil Chemical Structure
  65. GC16821 TAE226(NVP-TAE226) TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226) Chemical Structure
  66. GC32737 TAK-243 (MLN7243) TAK-243 (MLN7243) (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis. TAK-243 (MLN7243) Chemical Structure
  67. GC32687 Takinib A TAK1 inhibitor Takinib Chemical Structure
  68. GC19346 Talampanel Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Talampanel Chemical Structure
  69. GC32753 Taltobulin (HTI-286) Taltobulin (HTI-286) (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin (HTI-286) inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis. Taltobulin (HTI-286) Chemical Structure
  70. GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) Taltobulin hydrochloride (HTI-286 hydrochloride) Chemical Structure
  71. GC13984 Tamibarotene A selective RARα agonist Tamibarotene Chemical Structure
  72. GC17901 Tamoxifen Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues. Tamoxifen Chemical Structure
  73. GC11669 Tamoxifen Citrate Antiestrogen drug Tamoxifen Citrate Chemical Structure
  74. GC15254 Tandutinib (MLN518) Tandutinib (MLN518) (MLN518) is a potent and selective inhibitor of the FLT3 with an IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50s of 0.17 μM and 0.20 μM, respectively. Tandutinib (MLN518) can be used for acute myelogenous leukemia (AML). Tandutinib (MLN518) has the ability to cross the blood-brain barrier. Tandutinib (MLN518) Chemical Structure
  75. GC38853 Tandutinib hydrochloride Tandutinib hydrochloride (MLN518 hydrochloride) is a potent and selective inhibitor of the FLT3 with an IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50s of 0.17 μM and 0.20 μM, respectively. Tandutinib hydrochloride can be used for acute myelogenous leukemia (AML). Tandutinib hydrochloride has the ability to cross the blood-brain barrier. Tandutinib hydrochloride Chemical Structure
  76. GN10797 Tangeretin Tangeretin Chemical Structure
  77. GC10294 Tasisulam antitumor agent Tasisulam Chemical Structure
  78. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Taurochenodeoxycholic acid (12-Deoxycholyltaurine) (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Chemical Structure
  79. GC37745 Taurodeoxycholic acid sodium hydrate

    Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

     Taurodeoxycholic acid sodium hydrate Chemical Structure
  80. GC34181 Tauroursodeoxycholate (TUDCA) Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK. Tauroursodeoxycholate (TUDCA) Chemical Structure
  81. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate Chemical Structure
  82. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. TBHQ (tert-Butylhydroquinone) Chemical Structure
  83. GC14853 TC ASK 10 ASK1 inhibitor TC ASK 10 Chemical Structure
  84. GC11488 TCS JNK 5a JNK2 and JNK3 inhibitor TCS JNK 5a Chemical Structure
  85. GC11990 TCS-PIM-1-4a Pim inhibitor TCS-PIM-1-4a Chemical Structure
  86. GC13667 Temozolomide

    Temozolomide is an oral activity alkylating agent that induces the formation of O6-methylguanine in DNA

     Temozolomide Chemical Structure
  87. GC12573 Temsirolimus

    A MTOR inhibitor

     Temsirolimus Chemical Structure
  88. GC10978 Terfenadine Histamine H1-receptor antagonist Terfenadine Chemical Structure
  89. GC37765 Terrestrosin D Terrestrosin D, a steroidal saponin from Tribulus terrestris L., induces cell cycle arrest and cancer cells apoptosis. Terrestrosin D has antiangiogenic activities. Terrestrosin D Chemical Structure
  90. GN10740 Tetrahydropalmatine Tetrahydropalmatine Chemical Structure
  91. GN10585 Tetramethylpyrazine Tetramethylpyrazine Chemical Structure
  92. GC10035 TG101209 An inhibitor of JAK2, FLT3, RET, and JAK3 TG101209 Chemical Structure
  93. GC14324 TG101348 (SAR302503) A JAK2 inhibitor TG101348 (SAR302503) Chemical Structure
  94. GC11298 TH-302 A hypoxia-activated anticancer agent TH-302 Chemical Structure
  95. GC17054 Thalidomide An immunomodulatory compound with diverse biological activities Thalidomide Chemical Structure
  96. GC11482 Thapsigargin

    Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump.

     Thapsigargin Chemical Structure
  97. GC45031 Thiamine (hydrochloride) Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. Thiamine (hydrochloride) Chemical Structure
  98. GC14366 Thioguanine A thiopurine analog Thioguanine Chemical Structure
  99. GC12387 Tiplaxtinin(PAI-039) Tiplaxtinin(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM. Tiplaxtinin(PAI-039) Chemical Structure
  100. GC14256 Tivantinib (ARQ 197) Tivantinib (ARQ 197) is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM. Tivantinib (ARQ 197) Chemical Structure
  101. GC38863 TK216 TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity. TK216 Chemical Structure

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