Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Targets for  Reactive Oxygen Species

Products for  Reactive Oxygen Species

  1. Cat.No. Product Name Information
  2. GC91910 Ferroptosis Inhibitor D1 Ferroptosis inhibitor D1 is a free radical scavenger and an inhibitor of ferroptosis. Ferroptosis Inhibitor D1 Chemical Structure
  3. GC32439 Ferulic acid sodium (Sodium ferulate) Ferulic acid sodium (Sodium ferulate) is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. Ferulic acid sodium (Sodium ferulate) Chemical Structure
  4. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin Fisetin-d5 Chemical Structure
  5. GC47387 G6PDi-1

    Glucose-6-phosphate Dehydrogenase Inhibitor 1

     An inhibitor of G6PDH G6PDi-1 Chemical Structure
  6. GN10388 Gallic acid

    NSC 20103, NSC 674319, 3,4,5Trihydroxybenzoic Acid

     Gallic acid Chemical Structure
  7. GC61436 Gallic acid hydrate Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid hydrate Chemical Structure
  8. GC49420 Gallic Acid-d2

    3,4,5-Trihydroxybenzoic Acid-d2

     An internal standard for the quantification of gallic acid Gallic Acid-d2 Chemical Structure
  9. GN10741 Garcinone D Garcinone D Chemical Structure
  10. GC47397 Gemfibrozil-d6

    CI-719-d6

     An internal standard for the quantification of gemfibrozil Gemfibrozil-d6 Chemical Structure
  11. GC49106 Gentisein

    NSC 329491

     A xanthone with diverse biological activities Gentisein Chemical Structure
  12. GC45706 GHK-Cu (acetate)

    Gly-His-Lys-Cu(II)

     A tripeptide-copper(II) complex GHK-Cu (acetate) Chemical Structure
  13. GC20007 Ginsenoside CK

    Ginsenoside Compound K, Ginsenoside IH901; Compound K

     Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance. Ginsenoside CK Chemical Structure
  14. GN10098 Glabridin Glabridin Chemical Structure
  15. GC92088 GLP-1 (28-36) amide (trifluoroacetate salt)

    Glucagon-like Peptide 1 (28-36) amide; Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

     Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide. GLP-1 (28-36) amide (trifluoroacetate salt) Chemical Structure
  16. GC32999 Glucoraphanin Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects. Glucoraphanin Chemical Structure
  17. GC30263 Glucosamine (D-Glucosamine) Glucosamine (D-Glucosamine) (D-Glucosamine (D-Glucosamine)) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine (D-Glucosamine) Chemical Structure
  18. GN10669 Glucosamine sulfate Glucosamine sulfate Chemical Structure
  19. GC49271 Glufosinate-d3 (hydrochloride) An internal standard for the quantification of glufosinate Glufosinate-d3 (hydrochloride) Chemical Structure
  20. GC31353 Glutathione oxidized (L-Glutathione oxidized)

    Glutathione Disulfide, GSSG

     Glutathione oxidized (L-Glutathione oxidized), an oxidized form of the antioxidant L-glutathione, acts as a signaling molecule that trigger the activation of antioxidant genes. Glutathione oxidized (L-Glutathione oxidized) Chemical Structure
  21. GC71733 Glutathione oxidized-13C4,15N2

    Glutathione oxidized-13C4,15N2 is the 13C and 15N labeled Glutathione oxidized .

     Glutathione oxidized-13C4,15N2 Chemical Structure
  22. GC36176 Gomisin D A lignan with diverse biological activities Gomisin D Chemical Structure
  23. GC91598 GPX4 16

    Glutathione Peroxidase 4 16

     GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4). GPX4 16 Chemical Structure
  24. GC18788 Graphislactone A Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. Graphislactone A Chemical Structure
  25. GC32681 GSK2795039 GSK2795039 is a potent inhibitor of NADPH oxidase 2 (NOX2) enzyme with an IC50 value of 0.18μM. GSK2795039 Chemical Structure
  26. GA10800 H-Cys(Me)-OH

    S-Methylcysteine, NSC 15387, SMC, SMLC

     H-Cys(Me)-OH Chemical Structure
  27. GC30006 H2DCFDA (DCFH-DA)

    DCFH, DCFHDA

    H2DCFDA(DCFH-DA) is a redox-sensitive fluorescent probe, which could be used to measure intracellular reactive oxygen species levels.

     H2DCFDA (DCFH-DA) Chemical Structure
  28. GC49855 Harmalol (hydrochloride hydrate)

    11-hydroxy Harmalan, Harmidol

     A β-carboline alkaloid and an active metabolite of harmaline Harmalol (hydrochloride hydrate) Chemical Structure
  29. GN10613 Hesperidin

    Cirantin, Hesperidoside, NSC 44184

     Hesperidin, a flavonoid from the peel of navel orange, inhibits lipid peroxidation with an IC50 value of 179.1μM. Hesperidin Chemical Structure
  30. GC33479 Hexaconazole ((-)-Hexaconazol)

    (±)-Hexaconazole

     Hexaconazole ((-)-Hexaconazol) is a systemic fungicide used for the control of many fungi particularly Ascomycetes and Basidiomycetes. Hexaconazole ((-)-Hexaconazol) Chemical Structure
  31. GC34116 Hexahydrocurcumin Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities. Hexahydrocurcumin Chemical Structure
  32. GC64595 HKSOX-1 (5/6-mixture) HKSOX-1 is a fluorescent probe which is used for imaging and detection of endogenous superoxide in live cells and in vivo. HKSOX-1 (5/6-mixture) Chemical Structure
  33. GC34617 HO-1-IN-1 HO-1-IN-1 (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM. HO-1-IN-1 Chemical Structure
  34. GC34618 HO-1-IN-1 hydrochloride Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM. HO-1-IN-1 hydrochloride Chemical Structure
  35. GC43870 HPF

    Hydroxyphenyl Fluorescein

     Hydroxyphenyl fluorescein (HPF) is the reagent that can directly detect highly reactive oxygen species (hROS). HPF Chemical Structure
  36. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin HT-2 Toxin-13C22 Chemical Structure
  37. GC19193 HTHQ

    HTHQ

     HTHQ, which is a hydroquinone monoalkyl ether, is a potent anti-oxidative agent, even at low dose levels. HTHQ Chemical Structure
  38. GC36262 Huangjiangsu A Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. Huangjiangsu A Chemical Structure
  39. GC91099 HUP-55

    A prolyl endopeptidase inhibitor

     HUP-55 Chemical Structure
  40. GC47439 Hydralazine-d4 (hydrochloride)

    1-Hydrazinophthalazine-d4

     A neuropeptide with diverse biological activities Hydralazine-d4 (hydrochloride) Chemical Structure
  41. GC52190 Imidazole Ketone Erastin

    IKE

     Imidazole Ketone Erastin is an effective and metabolically stable system xc- inhibitor and ferroptosis inducer. Imidazole Ketone Erastin Chemical Structure
  42. GC49290 Indoxyl Sulfate-d5 (potassium salt)

    An internal standard for the quantification of indoxyl sulfate

     Indoxyl Sulfate-d5 (potassium salt) Chemical Structure
  43. GC61440 Iprodione Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione Chemical Structure
  44. GC39600 Iron sucrose Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose Chemical Structure
  45. GC13795 Isobavachalcone

    Corylifolinin, IBC

     A chalcone and flavonoid with diverse biological activities Isobavachalcone Chemical Structure
  46. GN10264 Isochlorogenic acid A

    3,5-DCQA, Isochlorogenic Acid A

     Isochlorogenic acid A Chemical Structure
  47. GC39109 Isodeoxyelephantopin Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer. Isodeoxyelephantopin Chemical Structure
  48. GC52027 Isolariciresinol

    (+)-Cyclolariciresinol, (+)-Isolariciresinol, (7′S,8′R,8R)-Isolariciresinol

     A lignan with diverse biological activities Isolariciresinol Chemical Structure
  49. GN10041 Isoquercitrin

    Quercetin 3-(β-D-glucofuranoside), Quercetin 3-O-β-D-glucofuranoside

     Isoquercitrin Chemical Structure
  50. GC71923 Isorabaichromone Isorabaichromone is a potent antioxidant agent. Isorabaichromone Chemical Structure
  51. GC31272 Isosteviol ((-)-Isosteviol) Isosteviol ((-)-Isosteviol) ((-)-Isosteviol ((-)-Isosteviol)) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol ((-)-Isosteviol) Chemical Structure
  52. GC38803 J14 J14 is a reversible sulfiredoxin inhibitor with an IC50 of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death. J14 Chemical Structure
  53. GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210 JKE-1674 Chemical Structure
  54. GC47478 JKE-1716 A GPX4 inhibitor JKE-1716 Chemical Structure
  55. GC61993 Kaempferol 3-O-β-D-glucuronide

    Kaempferol 3-O-β-glucuronide

     Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide Chemical Structure
  56. GC48507 Kaempferol 3-O-galactoside

    Trifolin

     Kaempferol 3-O-galactoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana. Kaempferol 3-O-galactoside Chemical Structure
  57. GC49372 Kaempferol 7-neohesperidoside

    Kaempferol 7-O-neohesperidoside

     A flavonoid glycoside with antioxidant and anticancer activities Kaempferol 7-neohesperidoside Chemical Structure
  58. GC11770 Ketone Ester

    (R)-3-Hydroxybutyl (R)-3-hydroxybutyrate, ketone ester

     A ketone ester with anti-obesity and anticonvulsant activities Ketone Ester Chemical Structure
  59. GC49436 L-3-n-Butylphthalide

    (-)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(-)-3-Butylphthalide, L-NBP

     A phthalide with antiplatelet and neuroprotective activities L-3-n-Butylphthalide Chemical Structure
  60. GC11707 L-Ascorbyl 6-palmitate

    Ascorbylpalmitic Acid, NSC 402451

     L-Ascorbyl 6-palmitate is an ester formed from ascorbic acid and palmitic acid creating an vitamin C, it is also used as an antioxidant food additive. L-Ascorbyl 6-palmitate Chemical Structure
  61. GC47549 L-Carnosine-d4

    β-Alanyl-L-histidine-d4

     A neuropeptide with diverse biological activities L-Carnosine-d4 Chemical Structure
  62. GC52283 L-Cysteine-15N-d3

    L-Cys-15N-d3, L-(+)-Cysteine-15N-d3, (R)-Cysteine-15N-d3

     An internal standard for the quantification of L-cysteine L-Cysteine-15N-d3 Chemical Structure
  63. GC12203 L-Glutathione Reduced

    GSH

     Used to elute GST from glutathione agarose L-Glutathione Reduced Chemical Structure
  64. GC49560 L6H21 L6H21, a Chalcone derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 Chemical Structure
  65. GC15550 Lacidipine

    GX 1048, GR 43659X

     L-type calcium channel blocker Lacidipine Chemical Structure
  66. GC18190 Lecanoric Acid

    NSC 249981

    Lecanoric acid is a naturally occurring depside polyphenol isolated from a variety of lichens.

     Lecanoric Acid Chemical Structure
  67. GC90655 Lentztrehalose B

    A disaccharide microbial metabolite with diverse biological activities

     Lentztrehalose B Chemical Structure
  68. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 Leucettine L41 Chemical Structure
  69. GC49597 Leukotriene B4-d5

    LTB4-d5

     An internal standard for the quantification of LTB4 Leukotriene B4-d5 Chemical Structure
  70. GC36443 Levomefolic acid Levomefolic acid is an orally available, bioactive form of folic acid that crosses the blood-brain barrier. Levomefolic acid Chemical Structure
  71. GC71918 Linocinnamarin Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin Chemical Structure
  72. GN10423 Lipoic acid Lipoic acid Chemical Structure
  73. GN10582 Liquiritin Liquiritin Chemical Structure
  74. GC18789 Lobaric Acid Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. Lobaric Acid Chemical Structure
  75. GN10569 Lobetyolin

    Lobetyolin is a derivative of lobetyol substituted with a glucopyranose.

     Lobetyolin Chemical Structure
  76. GC49177 Loliolide

    (-)-Loliolide, NSC 289632

     Loliolide is a monoterpene lactone with diverse biological activities. Loliolide Chemical Structure
  77. GC36492 Luciferase Luciferase is an enzyme capable of catalyzing bioluminescent reactions. Luciferase Chemical Structure
  78. GC63049 Luciferase-IN-1 Luciferase-IN-1 is a luciferase inhibitor. Luciferase-IN-1 Chemical Structure
  79. GC47582 Lupulone A beta-acid Lupulone Chemical Structure
  80. GC61015 Luteolin 5-O-glucoside Luteolin 5-O-glucoside, a major flavonoidfrom Cirsium maackii, possesses anti-inflammatory activity. Luteolin 5-O-glucoside Chemical Structure
  81. GN10448 Lycopene

    NSC 407322

     Lycopene is a fat-soluble carotenoid molecule that is found in high concentrations in red fruits and vegetables and has a strong antioxidant effect. Lycopene Chemical Structure
  82. GC46031 Malabaricone B

    NSC 287967, NSC 630196

     A diarylnonanoid with diverse biological activities Malabaricone B Chemical Structure
  83. GC46028 Malabaricone C

    NSC 287968

     A diarylnonanoid with diverse biological activities Malabaricone C Chemical Structure
  84. GC40979 Maresin 1

    7(R)MaR1, 7(R)Maresin 1

    A 7,14-dihydroxy DHA formed from 14(S)-hydroperoxy DHA

     Maresin 1 Chemical Structure
  85. GC49486 Meglutol-d3

    Dicrotalic Acid-d3, 3-hydroxy 3-methyl Glutaric Acid-d3, HMG-d3, 3-methyl-3-Hydroxyglutaric Acid-d3, Medroglutaric Acid-d3, 3-hydroxy-3-Methylglutaric Acid-d3

     An internal standard for the quantification of meglutol Meglutol-d3 Chemical Structure
  86. GC30500 Melittoside An iridoid glycoside Melittoside Chemical Structure
  87. GC19759 Mesotrione Mesotrione is a herbicide belongs to the benzoylcyclohexanedione family. Mesotrione Chemical Structure
  88. GC48889 Methazolamide-d6

    L584601-d6

     An internal standard for the quantification of methazolamide Methazolamide-d6 Chemical Structure
  89. GC30046 Methoxy-PMS (1-Methoxy PMS)

    1-Methoxyphenazine methosulfate, 1-methoxy PMS

     Methoxy-PMS (1-Methoxy PMS) is a synthetic electron transfer agent widely used in biochemical analyses, such as the detection of dehydrogenase activity. As a redox mediator, it promotes electron transfer between NAD(P)H and tetrazolium salts to generate detectable formazan products. Methoxy-PMS ( C₁₄H₁₃N₂O₄S) is a methoxy-substituted derivative of phenazine methosulfate (PMS). The methoxy group on its phenazine ring significantly enhances its stability and solubility, improves its photostability and water solubility, and makes it suitable for long-term enzyme reactions, high-throughput screening, and efficient redox cycling in vitro experiments. Methoxy-PMS (1-Methoxy PMS) Chemical Structure
  90. GC47659 Methyl 3,4-Dihydroxyphenylacetate

    Methyl 2-(3,4-dihydroxyphenyl)acetate, 3,4-Dihydroxyphenylacetic acid methyl ester

     A polyphenol with antioxidant and antiviral activities Methyl 3,4-Dihydroxyphenylacetate Chemical Structure
  91. GC32170 Methyl gallate (Gallincin)

    Gallic Acid methyl ester, NSC 363001

     Methyl gallate (Gallincin) is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate (Gallincin) Chemical Structure
  92. GC91887 Methyl Salicylate-d4

    Methyl 2-hydroxybenzoate-d4

     Methyl salicylate-d4 is intended for use as an internal standard for the quantification of methyl salicylate by GC- or LC-MS. Methyl Salicylate-d4 Chemical Structure
  93. GC31794 Methyl vanillate

    Methyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator.

     Methyl vanillate Chemical Structure
  94. GC45513 MGR1   MGR1 Chemical Structure
  95. GC44190 MGR2 MGR2 is a negative control compound for the activity of the reactive oxygen species-generating probe MGR1. MGR2 Chemical Structure
  96. GC49521 MHY553

    NSC 33005

     An agonist of PPARα MHY553 Chemical Structure
  97. GC44191 MHY908 MHY908 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ that increases transcriptional activity of PPARα and PPARγ in a luciferase reporter assay in AC2F rat liver cells when used at a concentration of 5 μM. MHY908 Chemical Structure
  98. GC62564 Mito-LND

    Mito-Lonidamine

     Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells. Mito-LND Chemical Structure
  99. GC44199 MitoB

    MitoBoronic Acid

     MitoB is a ratiometric mass spectrometry probe that can be used for assessing changes in H2O2 within mitochondria in vivo. MitoB Chemical Structure
  100. GC47683 MitoB-d15 A neuropeptide with diverse biological activities MitoB-d15 Chemical Structure
  101. GC44201 MitoP

    MitoPhenol

     MitoP is a phenol product produced by the reaction of H2O2 with the ratiometric mass spectrometry probe MitoB. MitoP Chemical Structure

Items 201 to 300 of 456 total

per page
  2. 1
  3. 2
  4. 3
  5. 4
  6. 5

Set Descending Direction