Signaling Pathways

SAR441255 is a peptide triple agonist of the glucagon-like peptide 1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR).

Glucose-dependent Insulinotropic Polypeptide (GIP) (1-42) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion.

Glucose-dependent Insulinotropic Polypeptide (GIP) (human) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion in response to glucose.

Azocasein is a useful tracer molecule for characterizing the permeability of the top coat of the multilayer-coated polyester threads.

3,3-Dimethyl-1-butanol is an oral inhibitor that inhibits the production of trimethylamine (TMA) by microorganisms and suppresses different microbial TMA lyases.

Diamide is a commonly used thiol oxidant, also recognized as a highly cell-permeable reagent that can oxidize reduced glutathione (GSH) to oxidized glutathione (GSSG) without generating reactive oxygen species (ROS).

DL-Ethionine, an antagonist of Methionine, is toxic and a carcinogen.

Gentisuric acid has the molecular formula C₉H₉NO₅, a molecular weight of 211.17, and its chemical name is N-(2,5-dihydroxybenzoyl) glycine . Gentisuric acid is a metabolite of salicylic acid or aspirin and serves as a substrate for α-amidomonooxygenase (PAM), Gentisuric acid has the ability to alleviate DNA damage induced by mitomycin C

β-Glucan is a polysaccharide composed of D-glucose monomers linked by β-glycosidic bonds. β-Glucan has the functions of hypocholesterolemic, hypoglycemic, immunomodulatory, antitumor, antioxidant, and anti-inflammatory.

1,7-Heptanediol serves as a PROTAC linker for connecting E3 ubiquitin ligase ligands and target protein ligands.

Potassium Hyaluronate from Cockscomb is a large molecule composed of repeated disaccharide units, which is used as a skin conditioner in cosmetics and can penetrate into the dermis layer.

Polyglycolide is a thermoplastic and highly crystalline biodegradable polymer derived from glycolic acid.

ROS fluorescent probe DHE is the commonly used fluorescent dyes to measure ROS in cells and tissues at 480nm wavelength excitation and 610nm wavelength emission.

(S,S)-(+)-2,3-Butanediol is an important platform chemical and chiral building block.

Sulfo-SANPAH is a water-soluble, heterobifunctional crosslinker; Sulfo-SANPAH contains a primary amine-reactive NHS ester and a photoactivatable nitrophenyl azide group.

Stigmastanol is a saturated form of natural phytosterols, belonging to the phytosterol class of compounds, with a chemical structure similar to cholesterol.

γ-Tocotrienol (γ-T3) is a subtype of tocotrienol and a major type of vitamin E with two substituted methyl groups.

Thiomorpholine-3-carboxylic acid ethyl ester hydrochloride is an organic synthesis intermediate, primarily used as a raw material for reducing agents and catalysts in organic synthesis.

JY-2 is a moderately selective FoxO1 inhibitor with IC 50 of 22μM, JY-2 has moderate inhibitory effect on FoxO3a and FoxO4 too.

RNase R is an E. coli exoribonuclease which exhibits 3’-to-5’ exonuclease activity, efficiently digesting nearly all linear RNA species.

PROTAC CDK9 degrader-4 is a PROTAC protein degrader that targets CDK9 (cyclin-dependent kinase 9).

Phosphocreatine di-tris salt is a phosphorylated creatine molecule that serves as a high-energy phosphate reservoir in the muscles of vertebrates and some invertebrates, providing phosphate for the conversion of ADP to ATP.

Peptidoglycan from Bacillus subtilis(Peptidoglycan) is a major component of the bacterial cell wall and is a polymer composed of sugars and amino acids. Peptidoglycan forms a mesh-like layer outside the bacterial cell membrane, providing structural strength and rigidity to the bacteria. Peptidoglycan also acts as a bioactive molecule to regulate the development, physiology, and pathology of eukaryotic cells.

PC DBCO-PEG4-NHS ester is a PEG based PROTAC linker that can be used as a linker in click chemistry for the synthesis of PROTAC molecules.