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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC70581 (R)-ML375 (R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 . (R)-ML375 Chemical Structure
  3. GC71036 (R)-MPH-220 (R)-MPH-220 is the R isomer of MPH-220 . (R)-MPH-220 Chemical Structure
  4. GC72915 (R)-MRT199665 (R)-MRT199665 is an isomer of MRT199665. (R)-MRT199665 Chemical Structure
  5. GC73092 (R)-Necrocide 1 (R)-Necrocide 1 (compound (R)-38) a potent anticancer agent. (R)-Necrocide 1 Chemical Structure
  6. GC68475 (R)-Nicardipine

    (R)-YC-93 free base

     (R)-Nicardipine Chemical Structure
  7. GC67767 (R)-Olacaftor

    (R)-VX-440

     (R)-Olacaftor Chemical Structure
  8. GC72961 (R)-OP-1074 (R)-OP-1074 is the isomer of OP-1074 , and can be used as an experimental control. (R)-OP-1074 Chemical Structure
  9. GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride Chemical Structure
  10. GC67717 (R)-PF-04991532 (R)-PF-04991532 Chemical Structure
  11. GC72807 (R)-PI3Kδ-IN-15 (R)-PI3Kδ-IN-15 is the R-enantiomer of PI3Kδ-IN-15. (R)-PI3Kδ-IN-15 Chemical Structure
  12. GC72939 (R)-PR-924 (R)-PR-924 is the isomer of PR-924 , and can be used as an experimental control. (R)-PR-924 Chemical Structure
  13. GC68408 (R)-Praziquantel-d11 (R)-Praziquantel-d11 Chemical Structure
  14. GC68383 (R)-Preclamol

    (+)-3-PPP

     (R)-Preclamol Chemical Structure
  15. GC72922 (R)-Prinomastat

    (R)-AG3340; (R)-KB-R9896

     (R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (a MMP Inhibitor). (R)-Prinomastat Chemical Structure
  16. GC70848 (R)-Safinamide (R)-Safinamide, the enantiomer of safinamide , can inhibit MAO-B with an IC50 value of 0.45 μM. (R)-Safinamide Chemical Structure
  17. GC72753 (R)-SCH 546738 (R)-SCH 546738 is the R-isomer of SCH 546738. (R)-SCH 546738 Chemical Structure
  18. GC73509 (R)-SKBG-1 (R)-SKBG-1 is an RNA-binding protein NONO inhibitor. (R)-SKBG-1 Chemical Structure
  19. GC73187 (R)-Sortilin antagonist 1 (R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 Chemical Structure
  20. GC73312 (R)-STU104 (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 Chemical Structure
  21. GC69839 (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

    (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole derivative and an effective inhibitor of gastric H+/K+-ATPase. Its IC50 for canine kidney Na+/K+-ATPase is 98 nM. (R)-Tegoprazan has potential in the research of gastrointestinal diseases.

     (R)-Tegoprazan Chemical Structure
  22. GC70204 (R)-TTA-P2 (R)-TTA-P2 is the isomer of TTA-P2 , and can be used as an experimental control. (R)-TTA-P2 Chemical Structure
  23. GC70934 (R)-Vanzacaftor (R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR). (R)-Vanzacaftor Chemical Structure
  24. GC69847 (R)-VT104

    (R)-VT104 is the R-enantiomer of VT104. The IC50 value of (R)-VT104 for firefly luciferase is 0.1-1 μμ. VT104 is an orally active pan-TEAD deacetylase inhibitor.

     (R)-VT104 Chemical Structure
  25. GC73082 (R)-VX-11e (R)-VX-11e (Compound 1) is an ERK2 inhibitor. (R)-VX-11e Chemical Structure
  26. GC65884 (R,1R)-Tenofovir amibufenamide

    (R,1R)-HS-10234

     (R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) can be used for the purifying a tenofovir prodrug. Tynofovir (tenofovir) is a nucleoside acids reverse transcriptase inhibitors. (R,1R)-Tenofovir amibufenamide Chemical Structure
  27. GC73054 (R,R)-CPI-1612 (R,R)-CPI-1612 is the isomer of CPI-1612 , and can be used as an experimental control. (R,R)-CPI-1612 Chemical Structure
  28. GC14145 (R,R)-Formoterol

    (-)-Formoterol;Arformoterol;Formoterol

     β2-selective adrenergic agonist (R,R)-Formoterol Chemical Structure
  29. GC72759 (R,R)-S63845 (R,R)-S63845 is the isomer of S63845 , and can be used as an experimental control. (R,R)-S63845 Chemical Structure
  30. GC69836 (R,R)-VVD-118313

    (R,R)-VVD-118313 is an isomer of VVD-118313. VVD-118313 is a selective JAK1 inhibitor that can block JAK1-dependent phosphorylation and cytokine signaling. VVD-118313 can be used for cancer research.

     (R,R)-VVD-118313 Chemical Structure
  31. GC52185 (R,S)-Anatabine-d4

    (±)-Anatabine-d4

     (R,S)-Anatabine-d4 Chemical Structure
  32. GC72820 (R,S,R)-ML334

    (R,S,R)-LH601A

     (R,S,R)-ML334 is the isomer of ML334 , and can be used as an experimental control. (R,S,R)-ML334 Chemical Structure
  33. GC74173 (R,S,S,R,S)-Boc-Dap-NE (R,S,S,R,S)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE , and can be used as an experimental control. (R,S,S,R,S)-Boc-Dap-NE Chemical Structure
  34. GC69837 (R/S)-Alicaforsen

    (R/S)-ISIS-2302

    (R/S)-Alicaforsen is the racemic form of Alicaforsen, which consists of both R and S configurations. Alicaforsen is a 20-base length antisense oligonucleotide that inhibits the production of ICAM-1, an important adhesion molecule involved in the migration and transport process of white blood cells to inflammatory sites.

     (R/S)-Alicaforsen Chemical Structure
  35. GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride Chemical Structure
  36. GC70292 (Rac)-AMG8379 (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. (Rac)-AMG8379 Chemical Structure
  37. GC71831 (Rac)-Anemonin (Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin . (Rac)-Anemonin Chemical Structure
  38. GC74234 (Rac)-Apremilast

    (Rac)-CC-10004

     (Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast Chemical Structure
  39. GC69794 (Rac)-Arnebin 1

    (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-?Dimethylacrylshikonin

    (Rac)-Arnebin 1 is the racemic form of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. These compounds are naphthoquinones isolated from plants in the Lithospermum genus, with β,β-Dimethylacrylshikonin exhibiting anti-tumor activity.

     (Rac)-Arnebin 1 Chemical Structure
  40. GC68414 (Rac)-Atropine-d3

    (Rac)-Tropine tropate-d3; (Rac)-Hyoscyamine-d3

     (Rac)-Atropine-d3 Chemical Structure
  41. GC73029 (Rac)-Baxdrostat

    (Rac)-CIN-107

     (Rac)-Baxdrostat is the isomer of Baxdrostat , and can be used as an experimental control. (Rac)-Baxdrostat Chemical Structure
  42. GC71593 (Rac)-Bepotastine besilate (Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) , and can be used as an experimental control. (Rac)-Bepotastine besilate Chemical Structure
  43. GC69795 (Rac)-BIO8898

    (Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits the binding of CD154 to CD40-Ig, with an IC50 of 25 μM.

     (Rac)-BIO8898 Chemical Structure
  44. GC67993 (Rac)-Cotinine-d4

    (±)-Cotinine-d4; (Rac)-NIH-10498-d4

     (Rac)-Cotinine-d4 Chemical Structure
  45. GC69796 (Rac)-Etavopivat

    (Rac)-FT-4202

    (Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat. Etavopivat is an orally active activator of red blood cell pyruvate kinase-R (PKR), which can be used for research on sickle cell disease and other hemoglobin disorders.

     (Rac)-Etavopivat Chemical Structure
  46. GC70206 (Rac)-Golgicide A (Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. (Rac)-Golgicide A Chemical Structure
  47. GC73045 (Rac)-GSK-3484862 (Rac)-GSK-3484862 is the isomer of GSK-3484862 , and can be used as an experimental control. (Rac)-GSK-3484862 Chemical Structure
  48. GC72502 (Rac)-H-Thr-OMe hydrochloride (Rac)-H-Thr-OMe hydrochloride is the isomer of H-Thr-OMe hydrochloride , and can be used as an experimental control. (Rac)-H-Thr-OMe hydrochloride Chemical Structure
  49. GC73049 (Rac)-JBJ-04-125-02 acetate (Rac)-JBJ-04-125-02 acetate is the racemate of JBJ-04-125-02. (Rac)-JBJ-04-125-02 acetate Chemical Structure
  50. GC72991 (Rac)-Lisaftoclax

    (Rac)-APG-2575

     (Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research (CN112898295A). (Rac)-Lisaftoclax Chemical Structure
  51. GC71577 (Rac)-LY341495 (Rac)-LY341495 is the isomer of LY341495 , and can be used as an experimental control. (Rac)-LY341495 Chemical Structure
  52. GC73585 (Rac)-M826 (Rac)-M826 is the racemate of M826. (Rac)-M826 Chemical Structure
  53. GC71576 (Rac)-Moxifloxacin (Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is the isoform of Moxifloxacin Hydrochloride , which is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. (Rac)-Moxifloxacin Chemical Structure
  54. GC71574 (Rac)-NNC 55-0396 (Rac)-NNC 55-0396 is the racemate of NNC 55-0396 . (Rac)-NNC 55-0396 Chemical Structure
  55. GC66334 (Rac)-PF-184 hydrate (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects. (Rac)-PF-184 hydrate Chemical Structure
  56. GC71205 (Rac)-Reparixin (Rac)-Reparixin is the isomer of Reparixin , and can be used as an experimental control. (Rac)-Reparixin Chemical Structure
  57. GC71283 (Rac)-Rotigotine (Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. (Rac)-Rotigotine Chemical Structure
  58. GC69797 (Rac)-SHIN2

    (Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor with a 1,4-dihydropyran[2,3-c]pyrazole structure. It is involved in folate or one-carbon metabolism pathways and prevents viral infections. SHMT1 and SHMT2 are cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase respectively.

     (Rac)-SHIN2 Chemical Structure
  59. GC69798 (Rac)-SNC80

    (Rac)-NIH 10815

    (Rac)-SNC80 is the racemic form of SNC80. SNC80 (NIH 10815) is an effective and highly selective non-peptide delta-opioid receptor agonist with a Ki of 1.78 nM and IC50 of 2.73 nM. SNC80 has anti-nociceptive, anti-hyperalgesic, and antidepressant-like effects, and can be used in research on various types of headaches.

     (Rac)-SNC80 Chemical Structure
  60. GC74162 (Rac)-Tivantinib

    (Rac)-ARQ 197; (Rac)-ARQ 198

     (Rac)-Tivantinib is the isomer of Tivantinib , and can be used as an experimental control. (Rac)-Tivantinib Chemical Structure
  61. GC69799 (Rac)-ZLc-002

    (Rac)-ZLc-002 is an inhibitor that interacts with the binding protein between nNOS and nitric oxide synthase 1 (NOS1AP). It inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergistically reduces tumor cell viability with Paclitaxel.

     (Rac)-ZLc-002 Chemical Structure
  62. GC71532 (rel)-Eglumegad (rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad . (rel)-Eglumegad Chemical Structure
  63. GC73075 (rel)-ML-SI3

    trans-ML-SI3

     (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 Chemical Structure
  64. GC74166 (rel)-Tivantinib

    (rel)-ARQ 197; (rel)-(3R,4R)-ARQ 198

     (rel)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (rel)-Tivantinib Chemical Structure
  65. GC72543 (S)-(+)-N-3-Benzylnirvanol (S)-(+)-N-3-Benzylnirvanol is a drug used formetabolic regulation. (S)-(+)-N-3-Benzylnirvanol Chemical Structure
  66. GC25002 (S)-(-)-α-Methylbenzylamine (S)-(-)-α-Methylbenzylamine is a chiral auxiliary in the enantiodivergent synthesis of simple isoquinoline alkaloids. (S)-(-)-α-Methylbenzylamine Chemical Structure
  67. GC74262 (S)-(-)-O-Demethylbuchenavianine (S)-(-)-O-Demetlbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine Chemical Structure
  68. GC66076 (S)-1-Benzylpyrrolidin-3-ol (S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive drug Barnidipine hydrochloride (HY-107322). (S)-1-Benzylpyrrolidin-3-ol Chemical Structure
  69. GC52192 (S)-4'-nitro-Blebbistatin

    (-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin

     (S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. (S)-4'-nitro-Blebbistatin Chemical Structure
  70. GC70334 (S)-ar-Curcumene (S)-ar-Curcumene ((+)-alpha-Curcumene) is a natural compound. (S)-ar-Curcumene Chemical Structure
  71. GC70821 (S)-ARI-1 (S)-ARI-1 is an S-enantiomer of ARI-1. (S)-ARI-1 Chemical Structure
  72. GC73433 (S)-BAY 2965501 (S)-BAY 2965501 is the left-handed isomer of BAY 2965501. (S)-BAY 2965501 Chemical Structure
  73. GC70237 (S)-BAY 73-6691 (S)-BAY 73-6691 is the isomer of BAY 73-6691 , and can be used as an experimental control. (S)-BAY 73-6691 Chemical Structure
  74. GC73666 (S)-Bexicaserin (S)-Bexcaserin (compound 2) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases. (S)-Bexicaserin Chemical Structure
  75. GC73058 (S)-BRD9500 (S)-BRD9500 is the isomer of BRD9500 , and can be used as an experimental control. (S)-BRD9500 Chemical Structure
  76. GC71271 (S)-FTY720-phosphonate FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. (S)-FTY720-phosphonate Chemical Structure
  77. GC65877 (S)-GFB-12811 (S)-GFB-12811 (compound 596) is a potent and selective CDK5 inhibitor, with an IC50 value less than 10 nM. (S)-GFB-12811 can be used in the research of cell cycle progression, neuronal development, tumorigenesis. (S)-GFB-12811 Chemical Structure
  78. GC70624 (S)-GLPG0974 (S)-GLPG0974 is the isomer of GLPG0974 , and can be used as an experimental control. (S)-GLPG0974 Chemical Structure
  79. GC73078 (S)-GSK-3685032 (S)-GSK-3685032 is the isomer of GSK-3685032 , and can be used as an experimental control. (S)-GSK-3685032 Chemical Structure
  80. GC72866 (S)-GSK852 (S)-GSK852 is a diastereomer of GSK852. (S)-GSK852 Chemical Structure
  81. GC72836 (S)-Ibuprofen acyl-β-D-glucuronide

    (S)-Ibuprofen glucuronide

     (S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) is a compound used to study the metabolism and pharmacokinetics of S-ibuprofen, a non-steroidal anti-inflammatory drug. (S)-Ibuprofen acyl-β-D-glucuronide Chemical Structure
  82. GC69890 (S)-Imlunestrant tosylate

    (S)-LY-3484356 tosylate

    (S)-Imlunestrant tosylate ((S)-LY-3484356) is the (S)-enantiomer of Imlunestrant. It can be used for cancer research.

     (S)-Imlunestrant tosylate Chemical Structure
  83. GC69891 (S)-Indoximod-d3

    1-Methyl-L-tryptophan-d3; (S)-NLG-8189-d3

    (S)-Indoximod-d3 is the deuterated form of (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for cancer research.

     (S)-Indoximod-d3 Chemical Structure
  84. GC69904 (S)-JDQ-443

    (S)-NVP-JDQ443

    (S)-JDQ-443 is an isomer of JDQ-443. JDQ-443 is an orally effective and selective covalent KRAS G12C inhibitor. JDQ-443 has anti-tumor activity.

     (S)-JDQ-443 Chemical Structure
  85. GC73762 (S)-LTGO-33 (S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 Chemical Structure
  86. GC65997 (S)-LY3177833 hydrate (S)-LY3177833 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor. (S)-LY3177833 hydrate shows broad in vitro anticancer activity. (S)-LY3177833 hydrate Chemical Structure
  87. GC69914 (S)-Malic acid-d3

    (S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3

    (S)-Malic acid-d3 is the deuterated form of (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a naturally occurring dicarboxylic acid and a source of fruity sour taste, commonly used as a food additive.

     (S)-Malic acid-d3 Chemical Structure
  88. GC71218 (S)-mchm5U (S)-mchm5U is a hydroxylated form of mcm5U, may be present in tRNA from the silkworm Bombyx mori. (S)-mchm5U Chemical Structure
  89. GC67989 (S)-Mirtazapine

    (S)-Org3770; (S)-6-Azamianserin

     (S)-Mirtazapine Chemical Structure
  90. GC68410 (S)-Mirtazapine-d3

    (S)-Org3770 D3; (S)-6-Azamianserin D3

     (S)-Mirtazapine-d3 Chemical Structure
  91. GC68476 (S)-Nicardipine

    (S)-YC-93 free base

     (S)-Nicardipine Chemical Structure
  92. GC70340 (S)-NIK SMI1 (S)-NIK SMI1 is the isomer of NIK SMI1 , and can be used as an experimental control. (S)-NIK SMI1 Chemical Structure
  93. GC71642 (S)-Ofloxacin-d3 (S)-Ofloxacin-d3 is the deuterium labeled Levofloxacin. (S)-Ofloxacin-d3 Chemical Structure
  94. GC70925 (S)-Osanetant (S)-Osanetant is the S-enantiomer of Osanetant. (S)-Osanetant Chemical Structure
  95. GC70606 (S)-PF-04449613 (S)-PF-04449613 is the left-handed isomer of PF-04449613 . (S)-PF-04449613 Chemical Structure
  96. GC69941 (S)-Renzapride

    (S)-BRL 24924

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  97. GC71007 (S)-Retosiban (S)-Retosiban is the isomer of Retosiban , and can be used as an experimental control. (S)-Retosiban Chemical Structure
  98. GC70295 (S)-Ro 32-0432 (S)-Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. (S)-Ro 32-0432 Chemical Structure
  99. GC73372 (S)-Sabutoclax

    (S)-BI-97C1

     (S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax Chemical Structure
  100. GC73527 (S)-SAR131675 (S)-SAR131675 is the S-enantiomer of SAR131675 , a potent and selective VEGFR3 inhibitor and a click chemistry reagent. (S)-SAR131675 Chemical Structure
  101. GC72905 (S)-Setastine

    (S)-EGIS-2062 free acid; (S)-EGYT-2062 free acid

     (S)-Setastine ((S)-EGIS-2062 free acid) is a non-sedating, highly potent antagonist of H1 receptor-mediated responses. (S)-Setastine Chemical Structure

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