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Home >> Signaling Pathways

Signaling Pathways

The antibody-drug conjugate (ADC), a humanized or human monoclonal antibody conjugated with highly cytotoxic small molecules (payloads) through chemical linkers, is a novel therapeutic format and has great potential to make a paradigm shift in cancer chemotherapy. The three components of the ADC together give rise to a powerful oncolytic agent capable of delivering normally intolerable cytotoxins directly to cancer cells, which then internalize and release the cell-destroying drugs. At present, two ADCs, Adcetris and Kadcyla, have received regulatory approval with >40 others in clinical development.

ADCs are administered intravenously in order to prevent the mAb from being destroyed by gastric acids and proteolytic enzymes. The mAb component of the ADC enables it to circulate in the bloodstream until it finds and binds to tumor-specific cell surface antigens present on target cancer cells. Linker chemistry is an important determinant of the safety, specificity, potency and activity of ADCs. Linkers are designed to be stable in the blood stream (to conform to the increased circulation time of mAbs) and labile at the cancer site to allow rapid release of the cytotoxic drug. First generation ADCs made use of early cytotoxins such as the anthracycline, doxorubicin or the anti-metabolite/antifolate agent, methotrexate. Current cytotoxins have far greater potency and can be divided into three main groups: auristatins, maytansines and calicheamicins.

The development of site-specific conjugation methodologies for constructing homogeneous ADCs is an especially promising path to improving ADC design, which will open the way for novel cancer therapeutics.

References:

[1] Tsuchikama K, et al. Protein Cell. 2016 Oct 14. DOI:10.1007/s13238-016-0323-0.

[2] Peters C, et al. Biosci Rep. 2015 Jun 12;35(4). pii: e00225. doi: 10.1042/BSR20150089.

Targets for  Signaling Pathways

Products for  Signaling Pathways

  1. Cat.No. Product Name Information
  2. GC79783 (R)-Liquiritigenin

    (R)-4',7-Dihydroxyflavanone

     (R)-Liquiritigenin ((R)-4',7-Dihydroxyflavanone) is a MAO inhibitor that acts as an inhibitor of recombinant human MAO-A ( IC50 9.97 μM) and recombinant human MAO-B ( IC50 3.91 μM). (R)-Liquiritigenin Chemical Structure
  3. GC73528 (R)-M3913

    (R)-M3913(compound C-155) is a enantiomer of M3913.

     (R)-M3913 Chemical Structure
  4. GC71217 (R)-mchm5U (R)-mchm5U is a diastereomer of (S)-mchm5U . (R)-mchm5U Chemical Structure
  5. GC70839 (R)-Merimepodib (R)-Merimepodib is the isomer of Merimepodib , and can be used as an experimental control. (R)-Merimepodib Chemical Structure
  6. GC80315 (R)-Mevalonic acid sodium

    (R)-MVA sodium

     (R) -Mevalonic acid ( (R) -MVA) sodium is an isomer of Mevalonic acid. (R)-Mevalonic acid sodium Chemical Structure
  7. GC70870 (R)-MK-5046 (R)-MK-5046 is the isomer of MK-5046 , and can be used as an experimental control. (R)-MK-5046 Chemical Structure
  8. GC70581 (R)-ML375 (R)-ML375 ((R)-VU0483253) is an enantiomer of ML375 . (R)-ML375 Chemical Structure
  9. GC71036 (R)-MPH-220 (R)-MPH-220 is the R isomer of MPH-220 . (R)-MPH-220 Chemical Structure
  10. GC72915 (R)-MRT199665 (R)-MRT199665 is an isomer of MRT199665. (R)-MRT199665 Chemical Structure
  11. GC73092 (R)-Necrocide 1 (R)-Necrocide 1 (compound (R)-38) a potent anticancer agent. (R)-Necrocide 1 Chemical Structure
  12. GC68475 (R)-Nicardipine

    (R)-YC-93 free base

     (R)-Nicardipine Chemical Structure
  13. GC79263 (R)-Octopamine (R)-Octopamine is a Gs-coupled receptor agonist. (R)-Octopamine Chemical Structure
  14. GC72961 (R)-OP-1074 (R)-OP-1074 is the isomer of OP-1074 , and can be used as an experimental control. (R)-OP-1074 Chemical Structure
  15. GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride Chemical Structure
  16. GC80328 (R)-PAD-PF2 (R)-PAD-PF2 is an isomer of PAD-PF2. (R)-PAD-PF2 Chemical Structure
  17. GC72807 (R)-PI3Kδ-IN-15 (R)-PI3Kδ-IN-15 is the R-enantiomer of PI3Kδ-IN-15. (R)-PI3Kδ-IN-15 Chemical Structure
  18. GC72939 (R)-PR-924 (R)-PR-924 is the isomer of PR-924 , and can be used as an experimental control. (R)-PR-924 Chemical Structure
  19. GC68408 (R)-Praziquantel-d11 (R)-Praziquantel-d11 Chemical Structure
  20. GC68383 (R)-Preclamol

    (+)-3-PPP

     (R)-Preclamol Chemical Structure
  21. GC72922 (R)-Prinomastat

    (R)-AG3340; (R)-KB-R9896

     (R)-Prinomastat ((R)-AG3340) is the R-isomer of Prinomastat (a MMP Inhibitor). (R)-Prinomastat Chemical Structure
  22. GC70848 (R)-Safinamide (R)-Safinamide, the enantiomer of safinamide , can inhibit MAO-B with an IC50 value of 0.45 μM. (R)-Safinamide Chemical Structure
  23. GC79434 (R)-SARM1-IN-5 (R)-SARM1-IN-5 is the (R)-enantiomer of SARM1-IN-5. (R)-SARM1-IN-5 Chemical Structure
  24. GC72753 (R)-SCH 546738 (R)-SCH 546738 is the R-isomer of SCH 546738. (R)-SCH 546738 Chemical Structure
  25. GC73509 (R)-SKBG-1 (R)-SKBG-1 is an RNA-binding protein NONO inhibitor. (R)-SKBG-1 Chemical Structure
  26. GC73187 (R)-Sortilin antagonist 1 (R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 Chemical Structure
  27. GC73312 (R)-STU104 (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 Chemical Structure
  28. GC69839 (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

    (R)-Tegoprazan ((R)-CJ-12420; example 3) is a benzimidazole derivative and an effective inhibitor of gastric H+/K+-ATPase. Its IC50 for canine kidney Na+/K+-ATPase is 98 nM. (R)-Tegoprazan has potential in the research of gastrointestinal diseases.

     (R)-Tegoprazan Chemical Structure
  29. GC70204 (R)-TTA-P2 (R)-TTA-P2 is the isomer of TTA-P2 , and can be used as an experimental control. (R)-TTA-P2 Chemical Structure
  30. GC70934 (R)-Vanzacaftor (R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR). (R)-Vanzacaftor Chemical Structure
  31. GC79504 (R)-Verapamil

    Dexverapamil

     (R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil. (R)-Verapamil Chemical Structure
  32. GC69847 (R)-VT104

    (R)-VT104 is the R-enantiomer of VT104. The IC50 value of (R)-VT104 for firefly luciferase is 0.1-1 μμ. VT104 is an orally active pan-TEAD deacetylase inhibitor.

     (R)-VT104 Chemical Structure
  33. GC73082 (R)-VX-11e (R)-VX-11e (Compound 1) is an ERK2 inhibitor. (R)-VX-11e Chemical Structure
  34. GC80322 (R,R)-Alnodesertib

    (R,R)-ART0380

     (R,R)-ART0380 (Compound 38) is the enantiomer of ART0380. (R,R)-Alnodesertib Chemical Structure
  35. GC78916 (R,R)-ATV2301 (R,R)-ATV2301 is the R,R isomer of ATV2301. (R,R)-ATV2301 Chemical Structure
  36. GC80856 (R,R)-Bexobrutideg

    (R,R)-NX-5948; (R,R)-BTK-IN-24

     (R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg. (R,R)-Bexobrutideg Chemical Structure
  37. GC73054 (R,R)-CPI-1612 (R,R)-CPI-1612 is the isomer of CPI-1612 , and can be used as an experimental control. (R,R)-CPI-1612 Chemical Structure
  38. GC80012 (R,R)-Cyclo(Pro-Val) (R,R)-Cyclo(Pro-Val) is a trans (D-L) diastereoisomer of valyl-prolyl diketopiperazine (cyclic dipeptide) [1]. (R,R)-Cyclo(Pro-Val) Chemical Structure
  39. GC14145 (R,R)-Formoterol

    (-)-Formoterol;Arformoterol;Formoterol

     β2-selective adrenergic agonist (R,R)-Formoterol Chemical Structure
  40. GC80321 (R,R)-MMP-1-IN-1 (R,R)-MMP-1-IN-1 is the R,R-enantiomer of MMP-1-IN-1. (R,R)-MMP-1-IN-1 Chemical Structure
  41. GC72759 (R,R)-S63845 (R,R)-S63845 is the isomer of S63845 , and can be used as an experimental control. (R,R)-S63845 Chemical Structure
  42. GC69836 (R,R)-VVD-118313

    (R,R)-VVD-118313 is an isomer of VVD-118313. VVD-118313 is a selective JAK1 inhibitor that can block JAK1-dependent phosphorylation and cytokine signaling. VVD-118313 can be used for cancer research.

     (R,R)-VVD-118313 Chemical Structure
  43. GC79852 (R,S)-STT3A/B-IN-1 (R,S)-STT3A/B-IN-1 (compound 32), the racemate of STT3A/B-IN-1, is a STT3A/B inhibitor. (R,S)-STT3A/B-IN-1 Chemical Structure
  44. GC81349 (R,S)-YAP-TEAD-IN-2 (R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2. (R,S)-YAP-TEAD-IN-2 Chemical Structure
  45. GC72820 (R,S,R)-ML334

    (R,S,R)-LH601A

     (R,S,R)-ML334 is the isomer of ML334 , and can be used as an experimental control. (R,S,R)-ML334 Chemical Structure
  46. GC74173 (R,S,S,R,S)-Boc-Dap-NE (R,S,S,R,S)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE , and can be used as an experimental control. (R,S,S,R,S)-Boc-Dap-NE Chemical Structure
  47. GC69837 (R/S)-Alicaforsen

    (R/S)-ISIS-2302

    (R/S)-Alicaforsen is the racemic form of Alicaforsen, which consists of both R and S configurations. Alicaforsen is a 20-base length antisense oligonucleotide that inhibits the production of ICAM-1, an important adhesion molecule involved in the migration and transport process of white blood cells to inflammatory sites.

     (R/S)-Alicaforsen Chemical Structure
  48. GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride Chemical Structure
  49. GC70292 (Rac)-AMG8379 (Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. (Rac)-AMG8379 Chemical Structure
  50. GC71831 (Rac)-Anemonin (Rac)-Anemonin ((Rac)-Pulsatilla camphor) is the diastereoisomer of Anemonin . (Rac)-Anemonin Chemical Structure
  51. GC74234 (Rac)-Apremilast

    (Rac)-CC-10004

     (Rac)-Apremilast ((Rac)-CC-10004) is the racemic mixture of Apremilast. (Rac)-Apremilast Chemical Structure
  52. GC69794 (Rac)-Arnebin 1

    (Rac)-β,β-Dimethylacrylalkannin; (Rac)-β,β-?Dimethylacrylshikonin

    (Rac)-Arnebin 1 is the racemic form of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. These compounds are naphthoquinones isolated from plants in the Lithospermum genus, with β,β-Dimethylacrylshikonin exhibiting anti-tumor activity.

     (Rac)-Arnebin 1 Chemical Structure
  53. GC68414 (Rac)-Atropine-d3

    (Rac)-Tropine tropate-d3; (Rac)-Hyoscyamine-d3

     (Rac)-Atropine-d3 Chemical Structure
  54. GC73029 (Rac)-Baxdrostat

    (Rac)-CIN-107

     (Rac)-Baxdrostat is the isomer of Baxdrostat , and can be used as an experimental control. (Rac)-Baxdrostat Chemical Structure
  55. GC79563 (rac)-BDM88951 (rac)-BDM88951 is the racemate of BDM88951. (rac)-BDM88951 Chemical Structure
  56. GC71593 (Rac)-Bepotastine besilate (Rac)-Bepotastine (besilate) is the isomer of Bepotastine (besilate) , and can be used as an experimental control. (Rac)-Bepotastine besilate Chemical Structure
  57. GC69795 (Rac)-BIO8898

    (Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits the binding of CD154 to CD40-Ig, with an IC50 of 25 μM.

     (Rac)-BIO8898 Chemical Structure
  58. GC79104 (Rac)-Chem-0199 (Rac)-Chem-0199 is the racemic mixture of Chem-0199. (Rac)-Chem-0199 Chemical Structure
  59. GC80037 (Rac)-Dihydrokaempferol (Rac)-Dihydrokaempferol is a flavonoid compound. (Rac)-Dihydrokaempferol Chemical Structure
  60. GC78896 (Rac)-Emtricitabine S-oxide

    (Rac)-Emtricitabine sulfoxide; (Rac)-Emtricitabine Degradant-III

     (Rac)-Emtricitabine S-oxide ((Rac)-Emtricitabine sulfoxide; (Rac)-Emtricitabine Degradant-III) is Emtricitabine S-oxide racemic modification. (Rac)-Emtricitabine S-oxide Chemical Structure
  61. GC69796 (Rac)-Etavopivat

    (Rac)-FT-4202

    (Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat. Etavopivat is an orally active activator of red blood cell pyruvate kinase-R (PKR), which can be used for research on sickle cell disease and other hemoglobin disorders.

     (Rac)-Etavopivat Chemical Structure
  62. GC70206 (Rac)-Golgicide A (Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. (Rac)-Golgicide A Chemical Structure
  63. GC73045 (Rac)-GSK-3484862 (Rac)-GSK-3484862 is the isomer of GSK-3484862 , and can be used as an experimental control. (Rac)-GSK-3484862 Chemical Structure
  64. GC72502 (Rac)-H-Thr-OMe hydrochloride (Rac)-H-Thr-OMe hydrochloride is the isomer of H-Thr-OMe hydrochloride , and can be used as an experimental control. (Rac)-H-Thr-OMe hydrochloride Chemical Structure
  65. GC73049 (Rac)-JBJ-04-125-02 acetate (Rac)-JBJ-04-125-02 acetate is the racemate of JBJ-04-125-02. (Rac)-JBJ-04-125-02 acetate Chemical Structure
  66. GC72991 (Rac)-Lisaftoclax

    (Rac)-APG-2575

     (Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research (CN112898295A). (Rac)-Lisaftoclax Chemical Structure
  67. GC80490 (Rac)-LRK-4189 (Rac)-LRK-4189 is the racemate of LRK-4189. (Rac)-LRK-4189 Chemical Structure
  68. GC71577 (Rac)-LY341495 (Rac)-LY341495 is the isomer of LY341495 , and can be used as an experimental control. (Rac)-LY341495 Chemical Structure
  69. GC73585 (Rac)-M826 (Rac)-M826 is the racemate of M826. (Rac)-M826 Chemical Structure
  70. GC78978 (rac)-Mitiperstat

    (rac)-AZD4831

     (rac)-Mitiperstat ((rac)-AZD4831) is the racemic form of Mitiperstat. (rac)-Mitiperstat Chemical Structure
  71. GC71576 (Rac)-Moxifloxacin (Rac)-Moxifloxacin ((Rac)-BAY 12-8039 free base) is the isoform of Moxifloxacin Hydrochloride , which is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. (Rac)-Moxifloxacin Chemical Structure
  72. GC79410 (rac)-NDT-19795 (rac)-NDT-19795 is the racemate of NDT-19795. (rac)-NDT-19795 Chemical Structure
  73. GC80489 (rac)-Nerandomilast

    (rac)-BI 1015550

     (rac)-Nerandomilast ((rac)-BI 1015550) is a mixture of enantiomeric isomers of Nerandomilast, among which only the (R)-enantiomer (i.e., Nerandomilast ) has PDE4B inhibitory activity; the (S)-enantiomer (i.e., (S)-Nerandomilast ) is basically inactive. (rac)-Nerandomilast Chemical Structure
  74. GC71574 (Rac)-NNC 55-0396 (Rac)-NNC 55-0396 is the racemate of NNC 55-0396 . (Rac)-NNC 55-0396 Chemical Structure
  75. GC71205 (Rac)-Reparixin (Rac)-Reparixin is the isomer of Reparixin , and can be used as an experimental control. (Rac)-Reparixin Chemical Structure
  76. GC71283 (Rac)-Rotigotine (Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. (Rac)-Rotigotine Chemical Structure
  77. GC69797 (Rac)-SHIN2

    (Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor with a 1,4-dihydropyran[2,3-c]pyrazole structure. It is involved in folate or one-carbon metabolism pathways and prevents viral infections. SHMT1 and SHMT2 are cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase respectively.

     (Rac)-SHIN2 Chemical Structure
  78. GC69798 (Rac)-SNC80

    (Rac)-NIH 10815

    (Rac)-SNC80 is the racemic form of SNC80. SNC80 (NIH 10815) is an effective and highly selective non-peptide delta-opioid receptor agonist with a Ki of 1.78 nM and IC50 of 2.73 nM. SNC80 has anti-nociceptive, anti-hyperalgesic, and antidepressant-like effects, and can be used in research on various types of headaches.

     (Rac)-SNC80 Chemical Structure
  79. GC74162 (Rac)-Tivantinib

    (Rac)-ARQ 197; (Rac)-ARQ 198

     (Rac)-Tivantinib is the isomer of Tivantinib , and can be used as an experimental control. (Rac)-Tivantinib Chemical Structure
  80. GC79253 (Rac)-Ulotaront hydrochloride

    (Rac)-SEP-363856 hydrochloride; (Rac)-SEP-856 hydrochloride

     (Rac)-Ulotaront hydrochloride ((Rac)-SEP-363856 hydrochloride) is the racemate of Ulotaront hydrochloride. (Rac)-Ulotaront hydrochloride Chemical Structure
  81. GC69799 (Rac)-ZLc-002

    (Rac)-ZLc-002 is an inhibitor that interacts with the binding protein between nNOS and nitric oxide synthase 1 (NOS1AP). It inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergistically reduces tumor cell viability with Paclitaxel.

     (Rac)-ZLc-002 Chemical Structure
  82. GC79590 (Rac)-δ-Viniferin (Rac)-δ-Viniferin is a racemate of δ-Viniferin, an isomer of ε-Viniferin. (Rac)-δ-Viniferin Chemical Structure
  83. GC71532 (rel)-Eglumegad (rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad . (rel)-Eglumegad Chemical Structure
  84. GC73075 (rel)-ML-SI3

    trans-ML-SI3

     (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 Chemical Structure
  85. GC74166 (rel)-Tivantinib

    (rel)-ARQ 197; (rel)-(3R,4R)-ARQ 198

     (rel)-Tivantinib is a potent and highly selective inhibitor of the receptor tyrosine kinase c-MET. (rel)-Tivantinib Chemical Structure
  86. GC79636 (RS)-Pantoic acid sodium monohydrate (RS) -Pantoic acid sodium monohydrate is an intermediate in the phosphopantothenate biosynthesis pathway for the de novo synthesis of R-pantothenate (vitamin B5) from valine in plants and microorganisms. (RS)-Pantoic acid sodium monohydrate Chemical Structure
  87. GC72543 (S)-(+)-N-3-Benzylnirvanol (S)-(+)-N-3-Benzylnirvanol is a drug used formetabolic regulation. (S)-(+)-N-3-Benzylnirvanol Chemical Structure
  88. GC25002 (S)-(-)-α-Methylbenzylamine (S)-(-)-α-Methylbenzylamine is a chiral auxiliary in the enantiodivergent synthesis of simple isoquinoline alkaloids. (S)-(-)-α-Methylbenzylamine Chemical Structure
  89. GC74262 (S)-(-)-O-Demethylbuchenavianine (S)-(-)-O-Demetlbuchenavianine (Compound (S)-(−)-1) is a flavonoidal alkaloids. (S)-(-)-O-Demethylbuchenavianine Chemical Structure
  90. GC80033 (S)-3-Hydroxy-1,5-diphenylpentan-1-one (S)-3-Hydroxy-1,5-diphenylpentan-1-one is a natural phenolic compound. (S)-3-Hydroxy-1,5-diphenylpentan-1-one Chemical Structure
  91. GC79596 (S)-4-Hydroxymephenytoin (S) -4-Hydroxy mephenytoin is a metabolite derived from the stereoselective metabolism of mephenytoin. (S)-4-Hydroxymephenytoin Chemical Structure
  92. GC79514 (S)-6-Methylnicotine (S)-6-Methylnicotine is a nicotinic acetylcholine receptor ( nAChR ) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine Chemical Structure
  93. GC80045 (S)-7-Hydroxywarfarin (S)-7-Hydroxywarfarin is the S stereoisomer of 7-Hydroxywarfarin. (S)-7-Hydroxywarfarin Chemical Structure
  94. GC70334 (S)-ar-Curcumene (S)-ar-Curcumene ((+)-alpha-Curcumene) is a natural compound. (S)-ar-Curcumene Chemical Structure
  95. GC70821 (S)-ARI-1 (S)-ARI-1 is an S-enantiomer of ARI-1. (S)-ARI-1 Chemical Structure
  96. GC73433 (S)-BAY 2965501 (S)-BAY 2965501 is the left-handed isomer of BAY 2965501. (S)-BAY 2965501 Chemical Structure
  97. GC70237 (S)-BAY 73-6691 (S)-BAY 73-6691 is the isomer of BAY 73-6691 , and can be used as an experimental control. (S)-BAY 73-6691 Chemical Structure
  98. GC73666 (S)-Bexicaserin (S)-Bexcaserin (compound 2) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases. (S)-Bexicaserin Chemical Structure
  99. GC73058 (S)-BRD9500 (S)-BRD9500 is the isomer of BRD9500 , and can be used as an experimental control. (S)-BRD9500 Chemical Structure
  100. GC79592 (S)-DSM1465 (S)-DSM1465 is a Plasmodium dihydroorotate dehydrogenase ( DHODH ) inhibitor. (S)-DSM1465 Chemical Structure
  101. GC78936 (S)-Edelfosine

    (S)-ET-18-OCH3

     (S)-Edelfosine ((S)-ET-18-OCH3) is the (S)-enantiomer of Edelfosine (ET-18-OCH3). (S)-Edelfosine Chemical Structure

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