Innate Immunity

Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria.

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors.

Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively.

BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.

BXL-628 (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist.

(S)-Indoximod (1-Methyl-L-tryptophan) is a novel, orally active IDO Pathway inhibitor (K i =19μM).

Sivelestat sodium tetrahydrate is a specific inhibitor of neutrophil elastase with an IC 50 value of 14nM.

Cyclic di-GMP disodium is a cyclic dinucleotide signaling molecule synthesized by bacteria and is a STING agonist.

Ermanin is a flavonoid isolated from Tanacetum microphyllum.

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM.

Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases.

α-Amyrin is a pentacyclic triterpenoid.

Also known as yeast polysaccharides. Light gray powder, almost insoluble in water, but can be dispersed into a uniform suspension in water. It is a polysaccharide rich in glucose and mannose extracted from yeast cell walls or yeast cells.

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

Tetrahydrocoptisine ((RS)-Stylopine) (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.

DCC-3014 (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively.

Quinolactacin A is a TNF production inhibitor.

Fuscin is a quinonoid fungal metabolite originally isolated from O.

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S.

Pro-adrenomedullin (45-92) (MR-proADM) is a peptide that is comprised of amino acid residues 45-92 of preproadrenomedullin.