Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Metabolism >> PDE

PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for  PDE

  1. Cat.No. Product Name Information
  2. GC36541 Mardepodect hydrochloride Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier. Mardepodect hydrochloride Chemical Structure
  3. GC16849 MBCQ cGMP-specific phosphodiesterase PDE V inhibitor MBCQ Chemical Structure
  4. GC13657 Mesopram PDE4 inhibitor, orally active Mesopram Chemical Structure
  5. GC14868 Milrinone PDE-3 inhibitor Milrinone Chemical Structure
  6. GC36616 Mirodenafil Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil Chemical Structure
  7. GC36617 Mirodenafil dihydrochloride A PDE5 inhibitor Mirodenafil dihydrochloride Chemical Structure
  8. GC16072 ML-030 PDE4 inhibitor ML-030 Chemical Structure
  9. GC12878 MMPX calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor MMPX Chemical Structure
  10. GC39539 Moracin M Moracin M, a phenolic component in the skin of Morus alba L. Moracin M Chemical Structure
  11. GC36653 MR-L2 MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 Chemical Structure
  12. GC36659 MT-3014 MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. MT-3014 Chemical Structure
  13. GC11684 MY-5445 PDE5 inhibitor MY-5445 Chemical Structure
  14. GC63308 N-Desmethyl Sildenafil-d8 N-Desmethyl Sildenafil-d8 Chemical Structure
  15. GC11072 Nortadalafil Nortadalafil Chemical Structure
  16. GC64844 NPD-001 NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 Chemical Structure
  17. GC36769 NPD-1335 NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. NPD-1335 Chemical Structure
  18. GC32572 NSP-805 NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties. NSP-805 Chemical Structure
  19. GC36793 Oglemilast Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast Chemical Structure
  20. GC36803 Olprinone Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Chemical Structure
  21. GC17221 Olprinone Hydrochloride An inhibitor of PDE3 Olprinone Hydrochloride Chemical Structure
  22. GC64931 ONO-8430506 ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC90 of 100 nM for ATX activity in mouse plasma. ONO-8430506 Chemical Structure
  23. GC11782 Ophiobolin A calmodulin antagonist Ophiobolin A Chemical Structure
  24. GC39260 OR-1855 OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility. OR-1855 Chemical Structure
  25. GC39415 OR-1896 OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 Chemical Structure
  26. GC64773 Orismilast Orismilast (LEO-32731) is a PDE4 inhibitor used for the research of inflammatory diseases. Orismilast Chemical Structure
  27. GC36859 PAT-048 PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 Chemical Structure
  28. GC31888 PAT-505 PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. PAT-505 Chemical Structure
  29. GC30657 PDE IV-IN-1 PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases. PDE IV-IN-1 Chemical Structure
  30. GC36864 PDE-9 inhibitor PDE-9 inhibitor is useful for neurodegenerative diseases. PDE-9 inhibitor Chemical Structure
  31. GC30879 PDE1-IN-2 PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 Chemical Structure
  32. GC30978 PDE10-IN-1 PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders. PDE10-IN-1 Chemical Structure
  33. GC65360 PDE10-IN-5 PDE10-IN-5 is a phosphodiesterase 10 (PDE 10) inhibitor, can be used for researching certain central nervous system (CNS) disorders. PDE10-IN-5 Chemical Structure
  34. GC65258 PDE10A-IN-2 hydrochloride PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride Chemical Structure
  35. GC65039 PDE11-IN-1 PDE11-IN-1 is a PDE11 inhibitor and can be used for adrenal insufficiency research. PDE11-IN-1 Chemical Structure
  36. GC63505 PDE12-IN-1 PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 Chemical Structure
  37. GC36863 PDE12-IN-3 PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. PDE12-IN-3 Chemical Structure
  38. GC34705 PDE2/PDE10-IN-1 PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10 inhibitor with IC50s of 29 and 480 nM, respectively. PDE2/PDE10-IN-1 Chemical Structure
  39. GC68460 PDE4B-IN-3 PDE4B-IN-3 Chemical Structure
  40. GC68229 PDE5-IN-7 PDE5-IN-7 Chemical Structure
  41. GC69680 PDE9-IN-1

    PDE9-IN-1 is an effective selective and orally bioavailable inhibitor of phosphodiesterase-9 (PDE9), with an IC50 value of 8.7 nM.

     PDE9-IN-1 Chemical Structure
  42. GC40685 Pentoxifylline Pentoxifylline is a methylxanthine derivative. Pentoxifylline Chemical Structure
  43. GC68041 Pentoxifylline-d5 Pentoxifylline-d5 Chemical Structure
  44. GC50319 PF 04671536 hydrochloride Potent and selective PDE8B/8A inhibitor PF 04671536 hydrochloride Chemical Structure
  45. GC10648 PF-04447943 A PDE9A inhibitor PF-04447943 Chemical Structure
  46. GC47939 PF-04449613 A PDE9A inhibitor PF-04449613 Chemical Structure
  47. GC32701 PF-04957325 PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. PF-04957325 Chemical Structure
  48. GC65002 PF-05085727 PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM). PF-05085727 Chemical Structure
  49. GC30828 PF-05180999 A PDE2A inhibitor PF-05180999 Chemical Structure
  50. GC69692 PF-06445974

    PF-06445974 is a positron emission tomography (PET) compound that effectively targets PDE4B with an IC50 of <1 nM. Its IC50 values for PDE4D, PDE4A, and PDE4C are 36, 4.7, and 17 nM respectively. PF-06445974 has good selectivity for PDE4D and excellent brain penetrance, allowing for high-level specific binding in "cold tracer" studies.

     PF-06445974 Chemical Structure
  51. GC15194 PF-2545920 A potent inhibitor of PDE10A PF-2545920 Chemical Structure
  52. GC14510 PF-8380 An inhibitor of autotaxin PF-8380 Chemical Structure
  53. GC36886 PF-8380 hydrochloride PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. PF-8380 hydrochloride Chemical Structure
  54. GC13121 Piclamilast PDE4 inhibitor Piclamilast Chemical Structure
  55. GC12808 Pimobendan An inhibitor of PDE3 Pimobendan Chemical Structure
  56. GC17422 Pimobendan hydrochloride Selective inhibitor of PDE3 Pimobendan hydrochloride Chemical Structure
  57. GC32503 Prinoxodan (RGW2938) Prinoxodan (RGW2938) (RGW2938) is a phosphodiesterase inhibitor. Prinoxodan (RGW2938) Chemical Structure
  58. GC32524 R 80123 R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. R 80123 Chemical Structure
  59. GC32495 Revizinone (R80122) Revizinone (R80122) is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. Revizinone (R80122) Chemical Structure
  60. GC13842 Ro 20-1724

    PDE4 inhibitor

     Ro 20-1724 Chemical Structure
  61. GC32555 Ro-15-2041 Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties. Ro-15-2041 Chemical Structure
  62. GC60329 Robustine Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. Robustine Chemical Structure
  63. GC16347 Roflumilast A PDE4 inhibitor Roflumilast Chemical Structure
  64. GC37553 Roflumilast Impurity E Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast Impurity E Chemical Structure
  65. GC37554 Roflumilast N-oxide A PDE4 inhibitor and active metabolite of roflumilast Roflumilast N-oxide Chemical Structure
  66. GC68325 Roflumilast-d4 N-Oxide Roflumilast-d4 N-Oxide Chemical Structure
  67. GC64522 Roflupram Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram Chemical Structure
  68. GC16629 Rolipram A phosphodiesterase-4 inhibitor Rolipram Chemical Structure
  69. GC15475 RS 25344 hydrochloride phosphodiesterase (PDE) 4 inhibitor RS 25344 hydrochloride Chemical Structure
  70. GC19314 RVT-501 RVT-501 (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM. RVT-501 Chemical Structure
  71. GC10077 S- (+)-Rolipram S- (+)-Rolipram Chemical Structure
  72. GC63997 S32826 disodium S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium Chemical Structure
  73. GC32545 Saterinone hydrochloride (BDF 8634 hydrochloride) Saterinone hydrochloride (BDF 8634 hydrochloride) is a phosphodiesterase III (PDE III) inhibitor. Saterinone hydrochloride (BDF 8634 hydrochloride) Chemical Structure
  74. GC31299 Sch59498 Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c). Sch59498 Chemical Structure
  75. GC65302 SDZ-MKS 492 SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 Chemical Structure
  76. GC32526 Senazodan Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III. Senazodan Chemical Structure
  77. GC63701 Senazodan hydrochloride Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III. Senazodan hydrochloride Chemical Structure
  78. GC38550 Siguazodan Siguazodan Chemical Structure
  79. GC14398 Siguazodan PDE3 inhibitor Siguazodan Chemical Structure
  80. GC11369 Sildenafil

    A PDE5 inhibitor

     Sildenafil Chemical Structure
  81. GC17685 Sildenafil Citrate A PDE5 inhibitor Sildenafil Citrate Chemical Structure
  82. GC15037 Sildenafil mesylate PDE5 inhibitor Sildenafil mesylate Chemical Structure
  83. GC33067 Sophoflavescenol Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 ?M, 0.17 ?M, 17.89 ?g/mL, 10.98 ?M, 8.37 ?M and 8.21 ?M, respectively. Sophoflavescenol Chemical Structure
  84. GC61747 Sp-cAMPS Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS Chemical Structure
  85. GC11125 Sp-Cyclic AMPS (sodium salt) Sp-Cyclic AMPS (sodium salt), a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-Cyclic AMPS (sodium salt) Chemical Structure
  86. GC11789 T 0156 hydrochloride T 0156 hydrochloride is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T 0156 hydrochloride Chemical Structure
  87. GC17074 Tadalafil A PDE5 inhibitor Tadalafil Chemical Structure
  88. GC63209 TAK-915 TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 Chemical Structure
  89. GC17999 TC-E 5005 PDE10A inhibitor TC-E 5005 Chemical Structure
  90. GC65925 TDP1 Inhibitor-1 TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM. TDP1 Inhibitor-1 Chemical Structure
  91. GC70002 TDP1 Inhibitor-2

    TDP1 Inhibitor-2 (compound 5) is an effective inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 can also inhibit SCAN1 (spinocerebellar ataxia with axonal neuropathy), with an IC50 of 3.5 μM.

     TDP1 Inhibitor-2 Chemical Structure
  92. GC32621 Theodrenaline ((±)-Theodrenaline) Theodrenaline ((±)-Theodrenaline) is a cardiac stimulant, also acts as an anti-hypotensive agent together with cafedrine. Theodrenaline ((±)-Theodrenaline) Chemical Structure
  93. GC50030 Theophylline Adenosine receptor antagonist; bronchodilator Theophylline Chemical Structure
  94. GC61943 Thioquinapiperifil dihydrochloride Thioquinapiperifil dihydrochloride (KF31327), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study. Thioquinapiperifil dihydrochloride Chemical Structure
  95. GC39453 THPP-1 A PDE10A inhibitor THPP-1 Chemical Structure
  96. GC31823 Tibenelast sodium (LY 186655) Tibenelast sodium (LY 186655) is a phosphodiesterase inhibitor. Tibenelast sodium (LY 186655) Chemical Structure
  97. GC63520 TMX-4100 TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma. TMX-4100 Chemical Structure
  98. GC64675 TMX-4113 TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer. TMX-4113 Chemical Structure
  99. GC62409 Tovinontrine Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. Tovinontrine Chemical Structure
  100. GC32454 TP-10 TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 Chemical Structure
  101. GC37817 TPN171 TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH). TPN171 Chemical Structure

Items 101 to 200 of 216 total

per page
  2. 1
  3. 2
  4. 3

Set Descending Direction