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Home >> Signaling Pathways >> Metabolism >> PDE

PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for  PDE

  1. Cat.No. Product Name Information
  2. GC60199 Ilexsaponin B2 Ilexsaponin B2 is a saponin isolated from the root of Ilex pubescens Hook. Ilexsaponin B2 Chemical Structure
  3. GC65911 Irsenontrine

    E2027

     Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine can be used for the research of neurological diseases. Irsenontrine Chemical Structure
  4. GC13191 Irsogladine PDE4 inhibitor Irsogladine Chemical Structure
  5. GC33878 Irsogladine maleate (Dicloguamine maleate) Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Irsogladine maleate (Dicloguamine maleate) Chemical Structure
  6. GC30811 ITI214 A PDE1 inhibitor ITI214 Chemical Structure
  7. GC30841 ITI214 free base ITI214 free base is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI214 free base Chemical Structure
  8. GC32633 K134 (OPC33509)

    OPC33509

     K134 (OPC33509) is a phosphodiesterase 3 (PDE3) inhibitor. K134 (OPC33509) Chemical Structure
  9. GC70519 Kuraridine Kuraridine is a prenylated flavonol extract from the roots ofSophora flavescens. Kuraridine Chemical Structure
  10. GC31258 L791943 L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM. L791943 Chemical Structure
  11. GC32529 LAS-31180 LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties. LAS-31180 Chemical Structure
  12. GC62525 LEO 39652 LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 Chemical Structure
  13. GC38921 Lirimilast

    BAY 19-8004

     Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast Chemical Structure
  14. GC36474 Lodenafil Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Lodenafil Chemical Structure
  15. GC36475 Lodenafil carbonate Lodenafil carbonate, a dimer that acts as a prodrug delivering Lodenafil in vivo, is an orally active phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). Lodenafil carbonate Chemical Structure
  16. GC36540 Mardepodect A potent inhibitor of PDE10A Mardepodect Chemical Structure
  17. GC36541 Mardepodect hydrochloride

    PF-2545920 hydrochloride

     Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier. Mardepodect hydrochloride Chemical Structure
  18. GC16849 MBCQ cGMP-specific phosphodiesterase PDE V inhibitor MBCQ Chemical Structure
  19. GC13657 Mesopram PDE4 inhibitor, orally active Mesopram Chemical Structure
  20. GC14868 Milrinone

    WIN 47,203

     PDE-3 inhibitor Milrinone Chemical Structure
  21. GC36616 Mirodenafil Mirodenafil (SK3530) is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil Chemical Structure
  22. GC36617 Mirodenafil dihydrochloride

    SK3530

     A PDE5 inhibitor Mirodenafil dihydrochloride Chemical Structure
  23. GC69471 MK-8189

    MK-8189 is an orally effective selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used for research on schizophrenia.

     MK-8189 Chemical Structure
  24. GC16072 ML-030

    CID-11757146

     PDE4 inhibitor ML-030 Chemical Structure
  25. GC12878 MMPX calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor MMPX Chemical Structure
  26. GC39539 Moracin M Moracin M is a phosphodiesterase 4 (PDE4) inhibitor (PDE4D2: IC50 = 2.9μM; PDE4B2: IC50 = 4.5μM; PDE5A1: IC50 > 40μM; PDE9A2: IC50 > 100μM) . Moracin M Chemical Structure
  27. GC70260 Motapizone Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone Chemical Structure
  28. GC36653 MR-L2 MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 Chemical Structure
  29. GC36659 MT-3014 MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. MT-3014 Chemical Structure
  30. GC70931 Mufemilast Mufemilast is a phosphodiesterase 4 (PDE4) inhibitor. Mufemilast Chemical Structure
  31. GC11684 MY-5445 PDE5 inhibitor MY-5445 Chemical Structure
  32. GC63308 N-Desmethyl Sildenafil-d8

    Desmethylsildenafil-D8; UK-103,320-d8

     N-Desmethyl Sildenafil-d8 Chemical Structure
  33. GC11072 Nortadalafil Nortadalafil Chemical Structure
  34. GC64844 NPD-001 NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 Chemical Structure
  35. GC36769 NPD-1335 NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. NPD-1335 Chemical Structure
  36. GC32572 NSP-805 NSP-805 is a potent and selective inhibitor of guinea pig cardiac phosphodiesterase 3 (PDE3), and a cardiotonic agent with vasodilator properties. NSP-805 Chemical Structure
  37. GC36793 Oglemilast Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast Chemical Structure
  38. GC36803 Olprinone Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Chemical Structure
  39. GC17221 Olprinone Hydrochloride

    Loprinone

     An inhibitor of PDE3 Olprinone Hydrochloride Chemical Structure
  40. GC64931 ONO-8430506 ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC90 of 100 nM for ATX activity in mouse plasma. ONO-8430506 Chemical Structure
  41. GC74014 OPB-171775 OPB-171775 is a molecular glue, which forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 Chemical Structure
  42. GC11782 Ophiobolin A

    Cochliobolin,NSC 114340

     calmodulin antagonist Ophiobolin A Chemical Structure
  43. GC39260 OR-1855 OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility. OR-1855 Chemical Structure
  44. GC39415 OR-1896 OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 Chemical Structure
  45. GC64773 Orismilast

    LEO-32731

     Orismilast (LEO-32731) is a PDE4 inhibitor used for the research of inflammatory diseases. Orismilast Chemical Structure
  46. GC36859 PAT-048 PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 Chemical Structure
  47. GC31888 PAT-505 PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. PAT-505 Chemical Structure
  48. GC30657 PDE IV-IN-1 PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for the research of asthma, COPD or other inflammatory diseases. PDE IV-IN-1 Chemical Structure
  49. GC36864 PDE-9 inhibitor PDE-9 inhibitor is useful for neurodegenerative diseases. PDE-9 inhibitor Chemical Structure
  50. GC30879 PDE1-IN-2 PDE1-IN-2 is a PDE1 inhibitor extracted from patent WO2016/55618 A1, example 31. PDE1-IN-2 Chemical Structure
  51. GC30978 PDE10-IN-1 PDE10-IN-1 is a potent PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1, for treating CNS and metabolic disorders. PDE10-IN-1 Chemical Structure
  52. GC65360 PDE10-IN-5 PDE10-IN-5 is a phosphodiesterase 10 (PDE 10) inhibitor, can be used for researching certain central nervous system (CNS) disorders. PDE10-IN-5 Chemical Structure
  53. GC65258 PDE10A-IN-2 hydrochloride PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride Chemical Structure
  54. GC65039 PDE11-IN-1 PDE11-IN-1 is a PDE11 inhibitor and can be used for adrenal insufficiency research. PDE11-IN-1 Chemical Structure
  55. GC63505 PDE12-IN-1 PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 Chemical Structure
  56. GC36863 PDE12-IN-3 PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. PDE12-IN-3 Chemical Structure
  57. GC34705 PDE2/PDE10-IN-1 PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10 inhibitor with IC50s of 29 and 480 nM, respectively. PDE2/PDE10-IN-1 Chemical Structure
  58. GC71356 PDE4-IN-14 PDE4-IN-14 (Compound 1) is a PDE4 inhibitor that can be used in the study of PDE4-related diseases (such as inflammatory and immune diseases, cancer, and metabolic diseases, etc. PDE4-IN-14 Chemical Structure
  59. GC68460 PDE4B-IN-3 PDE4B-IN-3 Chemical Structure
  60. GC70849 PDE5-IN-4 PDE5-IN-4 is a phosphodiesterase 5 inhibitor. PDE5-IN-4 Chemical Structure
  61. GC68229 PDE5-IN-7 PDE5-IN-7 Chemical Structure
  62. GC70202 PDE7-IN-3 Pde7-in-3 (example 2) is an inhibitor of the phosphodiesterase PDE7 with potential analgesic activity. PDE7-IN-3 Chemical Structure
  63. GC69680 PDE9-IN-1

    PDE9-IN-1 is an effective selective and orally bioavailable inhibitor of phosphodiesterase-9 (PDE9), with an IC50 value of 8.7 nM.

     PDE9-IN-1 Chemical Structure
  64. GC40685 Pentoxifylline

    NSC 637086, Oxpentifylline

     Pentoxifylline is a methylxanthine derivative. Pentoxifylline Chemical Structure
  65. GC68041 Pentoxifylline-d5

    BL-191-d5; PTX-d5; Oxpentifylline-d5

     Pentoxifylline-d5 Chemical Structure
  66. GC50319 PF 04671536 hydrochloride Potent and selective PDE8B/8A inhibitor PF 04671536 hydrochloride Chemical Structure
  67. GC70901 PF-00489791 PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC50 of 1.5 nM. PF-00489791 Chemical Structure
  68. GC10648 PF-04447943

    PF 04447943;PF04447943

     A PDE9A inhibitor PF-04447943 Chemical Structure
  69. GC47939 PF-04449613 A PDE9A inhibitor PF-04449613 Chemical Structure
  70. GC32701 PF-04957325 PF-04957325 is a kind of highly potent PDE8-selective inhibitor and the values of IC50 for PDE8A and PDE8B are 0.7nM and 0.3nM, respectively. PF-04957325 Chemical Structure
  71. GC65002 PF-05085727 PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC50=2 nM). PF-05085727 Chemical Structure
  72. GC30828 PF-05180999

    PF-999

     A PDE2A inhibitor PF-05180999 Chemical Structure
  73. GC69692 PF-06445974

    PF-06445974 is a positron emission tomography (PET) compound that effectively targets PDE4B with an IC50 of <1 nM. Its IC50 values for PDE4D, PDE4A, and PDE4C are 36, 4.7, and 17 nM respectively. PF-06445974 has good selectivity for PDE4D and excellent brain penetrance, allowing for high-level specific binding in "cold tracer" studies.

     PF-06445974 Chemical Structure
  74. GC15194 PF-2545920 A potent inhibitor of PDE10A PF-2545920 Chemical Structure
  75. GC14510 PF-8380 An inhibitor of autotaxin PF-8380 Chemical Structure
  76. GC36886 PF-8380 hydrochloride PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. PF-8380 hydrochloride Chemical Structure
  77. GC13121 Piclamilast

    RP 73401, RPR 73401

     PDE4 inhibitor Piclamilast Chemical Structure
  78. GC12808 Pimobendan

    UD-CG 115

     An inhibitor of PDE3 Pimobendan Chemical Structure
  79. GC17422 Pimobendan hydrochloride Selective inhibitor of PDE3 Pimobendan hydrochloride Chemical Structure
  80. GC32503 Prinoxodan (RGW2938) Prinoxodan (RGW2938) (RGW2938) is a phosphodiesterase inhibitor. Prinoxodan (RGW2938) Chemical Structure
  81. GC32524 R 80123 R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. R 80123 Chemical Structure
  82. GC32495 Revizinone (R80122) Revizinone (R80122) is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. Revizinone (R80122) Chemical Structure
  83. GC13842 Ro 20-1724

    4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

     Ro 20-1724 is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), with an IC50 value of 1.930μM. Ro 20-1724 Chemical Structure
  84. GC32555 Ro-15-2041 Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties. Ro-15-2041 Chemical Structure
  85. GC60329 Robustine Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro. Robustine Chemical Structure
  86. GC16347 Roflumilast

    B 9302107, BY 217, BYK 20869

     Roflumilast is an orally active selective phosphodiesterase-4 (PDE-4) inhibitor that inhibits the activity of PDE4A1 (IC50=0.7nM), PDE4A4 (IC50=0.9nM), PDE4B1 (IC50=0.7nM), and PDE4B2 (IC50=0.2nM). Roflumilast Chemical Structure
  87. GC37553 Roflumilast Impurity E Roflumilast Impurity E is the impurity of Roflumilast. Roflumilast Impurity E Chemical Structure
  88. GC37554 Roflumilast N-oxide A PDE4 inhibitor and active metabolite of roflumilast Roflumilast N-oxide Chemical Structure
  89. GC68325 Roflumilast-d4 N-Oxide Roflumilast-d4 N-Oxide Chemical Structure
  90. GC64522 Roflupram Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram Chemical Structure
  91. GC16629 Rolipram

    SB 95952, ZK 62711

     Rolipram is a selective inhibitor of phosphodiesterases (PDE) IV. Rolipram Chemical Structure
  92. GC15475 RS 25344 hydrochloride phosphodiesterase (PDE) 4 inhibitor RS 25344 hydrochloride Chemical Structure
  93. GC19314 RVT-501

    RVT-501

     RVT-501 (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM. RVT-501 Chemical Structure
  94. GC10077 S- (+)-Rolipram

    (+)-Rolipram; (S)-Rolipram

     S- (+)-Rolipram Chemical Structure
  95. GC63997 S32826 disodium S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium Chemical Structure
  96. GC32545 Saterinone hydrochloride (BDF 8634 hydrochloride)

    BDF 8634 hydrochloride

     Saterinone hydrochloride (BDF 8634 hydrochloride) is a phosphodiesterase III (PDE III) inhibitor. Saterinone hydrochloride (BDF 8634 hydrochloride) Chemical Structure
  97. GC31299 Sch59498 Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c). Sch59498 Chemical Structure
  98. GC65302 SDZ-MKS 492

    MKS 492

     SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 Chemical Structure
  99. GC32526 Senazodan Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III. Senazodan Chemical Structure
  100. GC63701 Senazodan hydrochloride

    MCI 154 hydrochloride

     Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III. Senazodan hydrochloride Chemical Structure
  101. GC38550 Siguazodan Siguazodan Chemical Structure

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