Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Ziele für Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Produkte für Neuroscience
- Bestell-Nr. Artikelname Informationen
- GC18022 (S)-Flurbiprofen (S)-Flurbiprofen ist ein aktives Enantiomer von Flurbiprofen mit IC50-Werten von 0,48 μM und 0,47 μM fÜr COX-1 bzw. COX-2.
- GC10739 (S)-HexylHIBO Group I mGlu receptor antagonist
- GC15977 (S)-Ketoprofen (S)-Ketoprofen ist ein potenter Inhibitor von COX-1 und COX-2 mit IC50-Werten von 1,9 bzw. 27 nM.
- GC41389 (S)-Ketorolac (S)-Ketorolac ist ein nichtsteroidales entzÜndungshemmendes Mittel.
- GC41738 (S)-KT109 (S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC16349 (S)-MCPG (S)-MCPG ((+)-MCPG) ist ein wirksamer metabotroper Glutamatrezeptor (mGluRs)-Antagonist der Gruppe I/II und das aktive Isomer von (RS)-MCPG.
- GC67989 (S)-Mirtazapine
- GC68410 (S)-Mirtazapine-d3
- GC14820 (S)-Naproxen (S)-Naproxen ist ein COX-1- und COX-2-Inhibitor mit IC50-Werten von 8,72 bzw. 5,15 &7#956;M im Zellassay.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC46355 (S)-Pramipexole-d5 (hydrochloride) An internal standard for the quantification of (S)-pramipexole
- GC33686 (S)-Rasagiline (TVP1022) (S)-Rasagilin (TVP1022) (TVP1022) ist die relativ inaktive S-Enantiomer-Form von Rasagilin.
- GC35006 (S)-Rasagiline mesylate (S)-Rasagilin (TVP1022)-Mesylat ist die relativ inaktive S-Enantiomer-Form von Rasagilin-Mesylat.
-
GC69941
(S)-Renzapride
(S)-Renzapride ((S)-BRL 24924) is the stereoisomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It is also an antagonist for 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).
- GC15464 (S)-SNAP 5114 (S)-SNAP 5114 ist ein selektiver GABA-Transportinhibitor mit IC50-Werten von 5 μM und 21 μM für hGAT-3 bzw. rGAT-2.
- GC60424 (S)-Venlafaxine (S)-Venlafaxin ist die (S)-Konfiguration von Venlafaxin. Venlafaxin ist ein oral aktiver, starker Serotonin (5-HT)/Noradrenalin (NE)-Wiederaufnahme-Dual-Hemmer. Venlafaxin ist ein Antidepressivum.
-
GC69979
(S)-VQW-765
(S)-VQW-765 ((S)-AQW-051) ist ein teilweise Agonist des α7-Nicotin-Acetylcholin-Rezeptors (nAChR), der eine orale Aktivität, Selektivität und Wirksamkeit aufweist. (S)-VQW-765 hat das Potenzial für Anwendungen bei kognitiven Beeinträchtigungen im Zusammenhang mit neurologischen Erkrankungen wie Alzheimer oder Schizophrenie.
- GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective
-
GC30212
(S)-Willardiine ((-)-Willardiine)
(S)-Willardiin ((-)-Willardiin) ist ein potenter Agonist von AMPA/Kainat-Rezeptoren mit einer EC50 von 44,8 uM.
- GC35011 (Z)-Thiothixene (Z)-Thiothixen ist ein Antagonist des serotonergen Rezeptors, extrahiert aus dem Patent US 20150141345 A1.
- GC18596 (±)-2-propyl-4-Pentenoic Acid (±)-2-Propyl-4-pentensÄure (4-en-VPA) ist ein wichtiger toxischer Metabolit von ValproinsÄure.
- GC12774 (±)-Anatoxin A fumarate (±)-Anatoxin A Fumarat ist ein natürliches Alkaloid, das aus Süßwasser-Cyanobakterien isoliert wird.
- GC12927 (±)-Baclofen (±)-Baclofen, ein lipophiles Derivat der γ-Aminobuttersäure (GABA), ist ein oral aktiver, selektiver metabotroper GABAB-Rezeptor (GABABR)-Agonist.
- GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor
- GC13786 (±)-Salsolinol (hydrochloride) depolarize dopamineric neurons
- GC14252 (–)-Stepholidine A dopamine receptor antagonist and 5-HT1A partial agonist
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC46366 1,2,3,4-Tetrahydro-β-carboline A serotonin reuptake inhibitor and metabolite of tryptamine
- GC45698 1,2,3-Triheptanoyl-rac-glycerol 1,2,3-Triheptanoyl-rac-glycerol (Propan-1,2,3-triyl triheptanoate) ist ein synthetisches mittelkettiges Triglycerid (MCT), das aus drei ungeradkettigen 7-Kohlenstoff-FettsÄuren (Heptanoat) auf einem Glycerol besteht RÜckgrat.
- GC41774 1,2,3-Trimyristoyl-rac-glycerol 1,2,3-Trimyristoyl-rac-glycerol, eine aktive molluskizide Komponente von Myristica fragransHoutt, hemmt signifikant die AktivitÄten von Acetylcholinesterase (AChE), saurer und alkalischer Phosphatase (ACP/ALP) im Nervengewebe von Lymnaea acuminata.
- GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3
- GC18334 1,2-Dierucoyl-sn-glycero-3-PC 1,2-Dierucoyl-sn-glycero-3-PC (DEPC) ist die Zusammensetzung der Liposomenmembran.
- GC42050 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-Glucosylsphingadienin (d18:2 (4E,8E)) ist ein Glucosylsphingosin, das deacetylierte Lysolipidderivate von Glucosylcerebrosiden sind.
- GC42051 1-β-D-Glucosylsphingosine (d18:1) 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides.
- GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors
- GC41751 1-(3,5-Dimethylphenyl)piperazine 1-(3,5-Dimethylphenyl)piperazine is a piperidine compound that is inactive at dopamine and serotonin receptors.
- GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist
-
GC16031
1-(3-Chlorophenyl)piperazine (hydrochloride)
5-HT2C/2B receptor agonist/partial agonist
- GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine
- GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.
- GC18009 1-Acetyl-4-methylpiperazine hydrochloride nAChR agonist
- GC12863 1-BCP 1-BCP (PiperonylsÄurepiperidid) ist ein zentral aktives Medikament, das Gating-StrÖme des AMPA-Rezeptors moduliert.
- GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin
- GC46050 1-Deoxysphingosine (m18:1(4E)) An atypical sphingolipid
- GC60447 1-Hydroxy-ibuprofen 1-Hydroxy-Ibuprofen ist ein Metabolit von Ibuprofen in P.
- GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective
- GC38698 1-Naphthyl acetate 1-Naphthylacetat ist ein attraktives chromogenes Substrat zum Nachweis von Erythrozyten-Acetylcholinesterase (AChE)-AktivitÄt.
- GC49818 1-Octen-3-ol 1-Octen-3-ol, eine duftende FettsÄure, ist ein selbststimulierender Oxylipin-Botenstoff.
- GC40910 1-Oleoyl-2-hydroxy-sn-glycero-3-PE 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.
- GC45979 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol A triacylglycerol
- GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC49088 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE A phospholipid
- GC42045 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively.
- GC40176 1-Stearoyl-rac-glycerol 1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position.
- GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
- GC13863 10Panx A peptide inhibitor of PANX1
- GC46412 11β-Prostaglandin F2α-d4 An internal standard for the quantification of 11β-PGF F2α
-
GC18798
11-cis Retinal
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.
- GC48821 11-cis Retinol An isomer of vitamin A
-
GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC49808 12-methyl Tridecanoic Acid A methylated fatty acid
- GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.
- GC41910 13-Docosenamide 13-Docosenamide is the amide of docosenoic acid.
- GC41907 13C C16 Sphingomyelin (d18:1/16:0) 13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion.
- GC41908 13C6 Glucosylsphingosine (d18:1) 13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.
- GC46437 14-dehydro Zymostenol A cholesterol precursor
- GC40988 15(R)-17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide.
- GC41922 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15.
- GC41093 15(S)-Latanoprost 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost.
- GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
- GC41934 15-keto Latanoprost 15-Keto-Latanoprost ist ein Metabolit von Latanoprost, einem augendrucksenkenden Mittel.
- GC40989 15-keto Latanoprost (free acid) 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals.
- GC41936 15-keto-17-phenyl trinor Prostaglandin F2α Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
- GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
- GC41947 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor.
- GC41948 16-phenoxy tetranor Prostaglandin F2α isopropyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC40961 16-phenoxy tetranor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC46451 16F16 A PDI inhibitor
- GC41207 17(R)-HDHA Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals.
- GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.
- GC17223 17-PA 17-PA ist ein selektiver Antagonist der Neurosteroid-Potenzierung und des direkten Gatings von GABAA-Rezeptoren.
- GC41960 17-phenoxy trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC40990 17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor.
- GC41967 17-phenyl trinor Prostaglandin F2α amide 17-Phenyltrinor Prostaglandin F2α Amid ist ein N-Desethyl-Metabolit von Bimatoprost.
- GC41969 17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide.
- GC41970 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis.
- GC41971 17-phenyl trinor Prostaglandin F2α diethyl amide 17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide.
- GC46458 17-phenyl trinor Prostaglandin F2α dimethyl amide An isomer of 17-phenyl trinor prostaglandin F2α ethyl amide
- GC41972 17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.
- GC41973 17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α.
- GC40392 17-phenyl trinor Prostaglandin F2α methyl ester 17-Phenyltrinor Prostaglandin F2α Methylester ist ein Prodrug von Bimatoprost.
- GC46463 17-phenyl trinor Prostaglandin F2α-d4 An internal standard for the quantification of bimatoprost (free acid)
- GC41975 17-trifluoromethylphenyl trinor Prostaglandin F2α A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.
- GC41976 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC41978 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC46466 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α A prostaglandin F derivative similar to latanoprost free acid
- GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
- GC60017 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, isoliert aus Arachis-Spezies, reguliert die 5-HT-, NE-, DA- und GABA-Signalwege hoch, hat aber keine sehr signifikante Wirkung auf den NE-Signalweg.