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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC40769 Asperphenamate Asperphenamate is a fungal secondary metabolite originally isolated from A. Asperphenamate Chemical Structure
  3. GC15706 Aspirin (Acetylsalicylic acid) A non-selective, irreversible COX inhibitor Aspirin (Acetylsalicylic acid) Chemical Structure
  4. GC11106 AT-101 AT-101 Chemical Structure
  5. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283 Chemical Structure
  6. GC35419 Atorvastatin Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin Chemical Structure
  7. GC14038 Atorvastatin Calcium An HMG-CoA reductase inhibitor Atorvastatin Calcium Chemical Structure
  8. GC16526 Atropine MAChRs antagonist Atropine Chemical Structure
  9. GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. Atropine sulfate monohydrate Chemical Structure
  10. GC62853 Aumitin Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin Chemical Structure
  11. GC46897 AUTEN-99 AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 Chemical Structure
  12. GC33683 Autocamtide 2 (Autocamtide II) Autocamtide 2 (Autocamtide II) is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). Autocamtide 2 (Autocamtide II) Chemical Structure
  13. GC34390 Autocamtide 2, amide Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays. Autocamtide 2, amide Chemical Structure
  14. GC35432 Autocamtide-2-related inhibitory peptide (TFA) Autocamtide-2-related inhibitory peptide (TFA) Chemical Structure
  15. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide Autocamtide-2-related inhibitory peptide, myristoylated Chemical Structure
  16. GC35433 Autogramin-1 Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM). Autogramin-1 Chemical Structure
  17. GC35434 Autogramin-2 Autogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM). Autogramin-2 Chemical Structure
  18. GC19453 Autophinib

    Autophinib is a potent autophagy inhibitor

     Autophinib Chemical Structure
  19. GC15295 AUY922 (NVP-AUY922) An Hsp90 inhibitor AUY922 (NVP-AUY922) Chemical Structure
  20. GC11081 Avermectin B1 An insecticide and anthelmintic Avermectin B1 Chemical Structure
  21. GC19479 AZ304

    A dual inhibitor

     AZ304 Chemical Structure
  22. GC35445 Azathramycin Azathramycin (Azaerythromycin A) is an antibiotic and targets ribosome. Azathramycin Chemical Structure
  23. GC14189 AZD-3463 ALK/IGF1R inhibitor AZD-3463 Chemical Structure
  24. GC12660 AZD1208 A pan-Pim kinase inhibitor AZD1208 Chemical Structure
  25. GC13029 AZD2014 AZD2014 (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes. AZD2014 Chemical Structure
  26. GC11752 AZD5363 AZD5363 (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. AZD5363 Chemical Structure
  27. GC16851 AZD6482

    PI3Kβ inhibitor,potent and selective

     AZD6482 Chemical Structure
  28. GC31924 AZD7624 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 Chemical Structure
  29. GC16380 AZD8055

    AZD8055 is a new ATP-competitive mTOR inhibitor with an IC50 of 0.8 nmol/L and a Ki of 1.3 nmol/L.

     AZD8055 Chemical Structure
  30. GC14507 Azithromycin Antibiotic by inhibiting protein synthesis Azithromycin Chemical Structure
  31. GC11304 Azithromycin Dihydrate Azithromycin Dihydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. Azithromycin Dihydrate Chemical Structure
  32. GC35462 Bafetinib

    Bcr-Abl/Lyn tyrosine kinase inhibitor

     Bafetinib Chemical Structure
  33. GC17597 Bafilomycin A1 Bafilomycin A1, a macrolide antibiotic isolated from the Streptomyces species, is an inhibitor of vacuolar H ATPase (V-ATPase). Bafilomycin A1 Chemical Structure
  34. GN10018 Baicalin

    A flavonoid with diverse biological activities

     Baicalin Chemical Structure
  35. GN10590 Bakuchiol Bakuchiol Chemical Structure
  36. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502 Chemical Structure
  37. GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity Bardoxolone methyl Chemical Structure
  38. GC13035 Bay 11-7821

    A selective and irreversible NF-κB inhibitor

     Bay 11-7821 Chemical Structure
  39. GN10443 Berbamine Berbamine Chemical Structure
  40. GN10358 Berbamine hydrochloride Berbamine hydrochloride Chemical Structure
  41. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

     Berberine Chemical Structure
  42. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate Chemical Structure
  43. GN10208 Berberine hydrochloride

    Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.

     Berberine hydrochloride Chemical Structure
  44. GN10523 Berberine Sulfate Berberine Sulfate Chemical Structure
  45. GN10539 Bergenin Bergenin Chemical Structure
  46. GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone Chemical Structure
  47. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid Chemical Structure
  48. GC10037 Bexarotene Retinoid Receptor agonist Bexarotene Chemical Structure
  49. GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities Bexarotene-d4 Chemical Structure
  50. GC10060 BEZ235 (NVP-BEZ235) A dual inhibitor of class I PI3Ks and mTOR BEZ235 (NVP-BEZ235) Chemical Structure
  51. GC13271 BEZ235 Tosylate BEZ235 Tosylate Chemical Structure
  52. GC35509 BGT226 BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. BGT226 Chemical Structure
  53. GC13468 BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable BI-D1870 Chemical Structure
  54. GC18174 BIA 10-2474 BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme). BIA 10-2474 Chemical Structure
  55. GC12271 Bicalutamide Androgen receptor antagonist Bicalutamide Chemical Structure
  56. GC18304 Bicyclol Bicyclol is a hepatoprotective agent. Bicyclol Chemical Structure
  57. GC60076 Bigelovin Bigelovin, a sesquiterpene lactone isolated from Inula helianthus-aquatica, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation. Bigelovin Chemical Structure
  58. GC12218 BIIB021 A potent, orally-available Hsp90 inhibitor BIIB021 Chemical Structure
  59. GC12541 Bilobalide A neuroprotective natural product Bilobalide Chemical Structure
  60. GN10618 Biochanin A Biochanin A Chemical Structure
  61. GC11497 BIRB 796 (Doramapimod) BIRB 796 (Doramapimod) (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. BIRB 796 (Doramapimod) Chemical Structure
  62. GN10037 Bisdemethoxycurcumin Bisdemethoxycurcumin Chemical Structure
  63. GC12171 BIX 01294 An inhibitor of G9a histone methyltransferase BIX 01294 Chemical Structure
  64. GC39481 BL-918 An ULK1 activator BL-918 Chemical Structure
  65. GC10593 BMS-582949 hydrochloride p38 MAPK inhibitor BMS-582949 hydrochloride Chemical Structure
  66. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100 Chemical Structure
  67. GC17644 Bortezomib (PS-341) Bortezomib (PS-341), as a dipeptide boronic acid proteasome inhibitor with antitumor activity, can potently inhibiit 20S proteasome with Ki of 0.6 nM by targeting a threonine residue.. Bortezomib (PS-341) Chemical Structure
  68. GC65010 Bortezomib-d8 Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8 Chemical Structure
  69. GC13343 Bosutinib (SKI-606) Bosutinib (SKI-606) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively. Bosutinib (SKI-606) Chemical Structure
  70. GC40080 Bosutinib-d8 Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib-d8 Chemical Structure
  71. GC30537 BPO-27 racemate BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM. BPO-27 racemate Chemical Structure
  72. GN10802 Brazilin Brazilin Chemical Structure
  73. GC17683 Brefeldin A

    Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.

     Brefeldin A Chemical Structure
  74. GC35554 Brevilin A A sesquiterpene lactone with anticancer activity Brevilin A Chemical Structure
  75. GC19083 Briciclib Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. Briciclib Chemical Structure
  76. GC35555 Britannin Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin Chemical Structure
  77. GC11692 Brivanib (BMS-540215) Brivanib (BMS-540215) (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Brivanib (BMS-540215) Chemical Structure
  78. GC14238 Brivanib Alaninate (BMS-582664) Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Brivanib Alaninate (BMS-582664) Chemical Structure
  79. GC16921 Bromhexine HCl Bromhexine HCl is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine HCl Chemical Structure
  80. GC13931 Bromocriptine mesylate

    D2-like dopamine receptor agonist

     Bromocriptine mesylate Chemical Structure
  81. GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains Bromodomain Inhibitor, (+)-JQ1 Chemical Structure
  82. GC10944 Butein Protein kinase inhibitor Butein Chemical Structure
  83. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    A bioactive sphingolipid

     C18 dihydro Ceramide (d18:0/18:0) Chemical Structure
  84. GC45616 C6 Urea Ceramide An inhibitor of neutral ceramidase C6 Urea Ceramide Chemical Structure
  85. GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects.. C646 Chemical Structure
  86. GC43105 C8 Ceramide (d18:1.8:0) C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8 Ceramide (d18:1.8:0) Chemical Structure
  87. GC33218 CA-5f A potent late-stage macroautophagy/autophagy inhibitor CA-5f Chemical Structure
  88. GC62881 CA77.1 CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 Chemical Structure
  89. GC11765 Cabazitaxel Microtubule associated inhibitor Cabazitaxel Chemical Structure
  90. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6 Chemical Structure
  91. GC10441 Cabergoline potent dopamine receptor agonist Cabergoline Chemical Structure
  92. GC13396 CAL-101 (Idelalisib, GS-1101) A selective PI3K p110δ inhibitor CAL-101 (Idelalisib, GS-1101) Chemical Structure
  93. GC60668 Calcimycin hemimagnesium Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium Chemical Structure
  94. GC30990 Calcineurin substrate Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Calcineurin substrate Chemical Structure
  95. GC38629 Calcineurin substrate (TFA) Calcineurin substrate (TFA) Chemical Structure
  96. GC14326 Calmidazolium chloride

    Calmodulin antagonist

     Calmidazolium chloride Chemical Structure
  97. GC31170 Calmodulin-Dependent Protein Kinase II 290-309 Calmodulin-Dependent Protein Kinase II 290-309 is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II 290-309 Chemical Structure
  98. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate Chemical Structure
  99. GC35601 CaMKII-IN-1 CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC. CaMKII-IN-1 Chemical Structure
  100. GC14065 Capsaicin A terpene alkaloid with diverse biological activities Capsaicin Chemical Structure
  101. GC17340 Carbamazepine Inhibitor of neuronal voltage-gated Na+ channels Carbamazepine Chemical Structure

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