Others

ERGi-USU-6 (mesylate) is a novel selective inhibitor of ERG-positive prostate cancer (IC50 = 0.089 μM).

EtDO-P4 is a nanomolar-level inhibitor of glycosphingolipid (GSL) synthesis. It inhibits the activation of various receptor tyrosine kinases (RTKs) and the ERK pathway induced by EGFR. EtDO-P4 can be used for research on various types of tumors, including Burkitt's lymphoma.

FC9402 is an efficient and selective inhibitor of sulfide quinone oxidoreductase (SQOR). It comes from patent WO 2020/146636 A1. FC9402 can reduce TAC-induced cardiomyocyte hypertrophy and left ventricular (LV) fibrosis. FC9402 can be used for cardiovascular regulation.

FPR2 agonist 2 is an effective FPR2 agonist that can penetrate the blood-brain barrier, with an EC50 value of 0.13 µM for h-FPR2. It inhibits the production of pro-inflammatory cytokines, counteracts changes in mitochondrial function, and suppresses caspase-3 activity.

GALK1-IN-1 (Compound 4) is a galactokinase inhibitor (IC50: 4.2129 μM).

GalNac-L96 is a oligonucleotide rich in G and has a long GalNAc linker, which can be used for delivering nucleic acid drugs.

GBT1118 is an effective orally active hemoglobin oxygen affinity modulator that increases tolerance to severe hypoxia.

GPR41 agonist-1 (compound 9) is an effective GPR41 agonist. It can be used for research on insulin-related diseases.

HDAC-IN-55(8j) is a small molecule compound that can increase the expression of E-cadherin and inhibit cancer cell proliferation.

hGPR91 antagonist 3 (Compound 5g) is an effective, selective, orally active hGPR91 (%F: 26) antagonist. The research on hGPR91 antagonist 3 has potential in hypertension, autoimmune diseases and retinal angiogenesis.

HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion proteins and the pseudokinase Her3.

IMP2-IN-1 (compound 4) is an effective inhibitor of IMP2, with an IC50 of 81.3-127.5 μM against the IMP2 RNA sequence. IMP2-IN-1 reduces the level of IMP2 in SW480 cells and significantly decreases the viability of differentiated and undifferentiated Huh7 cells.

IMP2-IN-2 (Compound 6) is an effective and selective inhibitor of IMP2, with IC50 values of 120.9 μM and 236.7 μM for inhibiting the interaction between IMP2 and RNA_A and RNA_B, respectively. IMP2-IN-2 can be used in cancer research.

INI-43 is an inhibitor of Kpnβ1, which interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1 and NFY.

Isochenodeoxycholic acid (isoCDCA) is a human fecal bile acid. Isochenodeoxycholic acid has a cytoprotective effect on HepG2 cells against ethanol-induced damage. Isochenodeoxycholic acid is the main metabolite of orally administered ursodeoxycholic acid (UDCA).

ISR-IN-1 (Compound 48) is an integrated stress response inhibitor (EC50: 0.6 nM).

ISR-IN-2 (Compound 47) is an integrated stress response inhibitor (EC50: 0.8 nM).

ISX-3 is an effective anti-fat generating agent and bone-promoting agent. ISX-3 increases the expression of PPARγ. ISX-3 has potential in researching osteoporosis and bone loss.

JBSNF-000028 hydrochloride is an orally active inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 values of 0.033 μM, 0.19 μM, and 0.21 μM for human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively.

JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 0.033 μM, 0.19 μM, and 0.21 μM for human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively.

KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor that can be used in the research of kidney disease, non-alcoholic fatty liver disease (NASH), diabetes, and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes fructose phosphate to form fructose-1-phosphate (FIP) while consuming ATP. If there is a lack of feedback inhibition in fructose metabolism, it can lead to the accumulation of downstream intermediates such as fat synthesis, gluconeogenesis, and oxidative phosphorylation.

KM04416 is a thiazolone derivative and an effective inhibitor of 3-phosphoglycerate dehydrogenase (GPD2). KM04416 significantly inhibits the proliferation of PNT1A cells.

Lauroylamide propylbetaine (Lauramidopropyl betaine) is a liquid detergent that can be used to enhance the viscosity of cosmetics and hair products, and has good biodegradability.

LONP1-IN-2 (compound 9d) is an effective selective inhibitor of LONP1, with IC50 values of 0.187 μM and >10 μM for LONP1 and the 20S proteasome, respectively. LONP1-IN-2 can be used in cancer research.