Others

LP-184 (compound 6) is an acyl fluoride ethylene analog that can inhibit tumor growth. LP-184 has effective anti-cancer activity in ovarian, colon, prostate and pancreatic cell lines and comes from patent WO2007019308A2.

M3913 is an anti-tumor compound. M3913 has anti-proliferative activity against cancer cells.

Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for the synthesis of antibody-drug conjugates (ADCs). Mal-Gly-PAB-Exatecan-D-glucuronic acid is also useful in research and diagnosis related to cancer.

MDH1-IN-1 (Compound 5i) is an effective inhibitor of MDH1 with an IC50 of 6.79 μM. MDH1-IN-1 has the potential to be used in cancer research.

MEL24 is a type of Mdm2 E3 ligase inhibitor that reduces cell survival in a p53-dependent manner and increases sensitivity to DNA damaging agents. It is used for in vitro anti-tumor research.

MenA-IN-2 (Compound 11) is a 1,4-dihydroxy-2-naphthoate ester isoprenyltransferase (MenA) inhibitor. The IC50 value of MenA-IN-2 for inhibiting MenA is 22 μM, and the GIC50 value of MenA-IN-2 for anti-tuberculosis Mycobacterium tuberculosis (Mtb) activity is 10 μM. MenA-IN-2 can suppress the continuous spread of Mtb.

Milategrast can be used as a cell adhesion inhibitor or cell infiltration inhibitor. In vitro, Milategrast inhibits the adhesion of Jurkat cells to human fibronectin with an IC50 of

ML162-yne is an effective GPX4 inhibitor affinity probe.

MLS001006105 is used for biological sequencing targeting protein targets: nuclear lamin isoform A-delta10.

MODAG-001 can bind to synaptic nuclear protein fibrils in the rat brain. MODAG-001 is a candidate α-syn imaging probe.

MRT-2359 is an orally effective GSPT1 degrader with anti-tumor activity. It also inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDX).

MRTX849 analog 24 is a probe for the KRAS G12C inhibitor MRTX849, used to study the function of MRTX849.

MS47134 is an effective and selective MRGPRX4 agonist with an EC50 of 149 nM. MS47134 can be used for the study of pain, itch, and mast cell-mediated hypersensitivity reactions.

Muvalaplin (LY3473329) is an orally active lipoprotein(a) [Lp(a)] agent, and research on Muvalaplin oral agents is currently underway.

Muzolimine (BAY-g 282) is a slow and long-acting diuretic. Muzolimine produces a diuretic effect within the Henle's loop of the kidney and has antihypertensive properties. Muzolimine can be used in research on cardiovascular diseases.

myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt of inositol tripyrophosphate (ITPP), which is a membrane permeability modulator of hemoglobin.

N-Acetyldopamine dimer-1 is a derivative of 2-(3',4'-dihydroxyphenyl)-1,4-benzodiazepine. It has optical activity and can be isolated from the exuviae of Cryptotympana sp., a species of cicada commonly known as "Zentai" in traditional Chinese medicine.

N-Acetyldopamine dimer-3 (compound 11) is a natural product found in Aspongopus chinensis.

NCGC00138783 TFA is a selective inhibitor targeting the CD47/SIRPα axis, with an IC50 of 50 μM. It directly blocks the interaction between CD47 and SIRPα.

Nelutroctiv is an effective cardiac myofilament calcium sensitizer.

NFAT Inhibitor-2 is an effective calcineurin NFAT signaling inhibitor. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has potential in researching inflammatory diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, uncontrolled cell proliferation and/or differentiation disorders, angiogenesis-related diseases, allergies, allergic reactions and hair loss (information taken from patent WO2016207212A1 compound 17).

In the biosynthesis of NAD+, Nicotinic acid mononucleotide triethylamine is formed from nicotinic acid (NA) through the action of nicotinic acid phosphoribosyltransferase. Nicotinate mononucleotide triethylamine serves as a substrate for nicotinamide mononucleotide/nicotinic acid mononucleotide adenylyltransferase.

Nitrosobiotin can be used to label secondary antibodies.

Octakis-(6-bromo-6-deoxy)-β-cyclodextrin is a β-cyclodextrin that has been fully brominated on the primary side and is commonly used as an intermediate in cyclodextrin modification.