Others

SC-VC-PAB-N-Me-L-Ala-Maytansinol (compound B1) can be used for the synthesis of MCC-Maytansinoid. SC-VC-PAB-N-Me-L-Ala-Maytansinol can serve as a reference compound for cancer research.

Sec61-IN-2 (A347) is an inhibitor of protein secretion (a compound derived from patent WO2020176863).

Sec61-IN-2 (A3) is an inhibitor of protein secretion (a compound derived from patent WO2020176863).

Sepin-1 is an effective separase inhibitor with an IC50 value of 14.8 µM. It inhibits cell proliferation, migration, and wound healing. Sepin-1 reduces the expression of FoxM1 protein and mRNA levels. Sepin-1 has anti-tumor activity.

Serine Hydrolase inhibitor-21 (compound 8) is a pyridine and a serine hydrolase inhibitor with a Ki of 429 nM for BuChE. It has potential for use in Alzheimer's disease research.

(S)-Imlunestrant tosylate ((S)-LY-3484356) is the (S)-enantiomer of Imlunestrant. It can be used for cancer research.

Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor with an IC50 value of 23.04 μM.

Sirpiglenastat (DRP-104) is a broad-spectrum glutamine antagonist. It has anti-cancer effects by directly targeting tumor metabolism and inducing effective anti-tumor immune responses at the same time.

SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of the interaction between SOD1 and Derlin-1. It inhibits the complex formation between SOD1G93A and Derlin-1 with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for research on amyotrophic lateral sclerosis.

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of the interaction between SOD1 and Derlin-1. It weakens the interaction between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for research on amyotrophic lateral sclerosis (ALS).

Sodium zirconium cyclosilicate is a new type of inorganic microporous silicate compound that is taken orally and not absorbed. It is a highly selective cation exchange resin that can selectively remove excess K+ from the body. Sodium zirconium cyclosilicate can be used for research on chronic kidney disease (CKD).

SPEN-IN-1 (compound X1) is an inhibitor of the protein factor SPEN, with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, which is a 431-nucleotide structural domain in Xist (a non-coding RNA prototype), consisting of 8.5 GC-rich motifs responsible for gene silencing.

(Please note that this is a chemical name and may not have a direct translation into English) (Please also note that the use of chemicals should only be done by trained professionals in appropriate settings with proper safety measures.) (Please consult with a professional chemist for accurate information regarding this compound.) The (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is part of PROTAC BRD4 Degrader-12.

Succinate/succinate receptor antagonist 1 (compound 7a) is a type of succinic acid receptor antagonist. It blocks the signal of succinic acid in gum tissue. Succinate/succinate receptor antagonist 1 inhibits the activation of succinic acid receptor 1 (SucnRl Antagonist 1), with an IC50 value of 20 μμ. It can be used for research on periodontal disease.

TP-5801 is an orally active inhibitor of non-receptor tyrosine kinase (TNK1) with an IC50 of 1.40 nM and exhibits anti-tumor activity.

TP-5801 TFA is an orally active inhibitor of non-receptor tyrosine kinase (TNK1) with an IC50 of 1.40 nM and exhibits anti-tumor activity.

TREM2 agonist-2 is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC 50 <0.05μM).

Trifludimoxazin is an inhibitor of protoporphyrinogen oxidase and can be used as a herbicide.

Tri-GalNAc-DBCO can bind to the asialoglycoprotein receptor (ASGPR) to drive protein downregulation and target protein degradation, where GalNAc is a high-affinity ligand for liver cell-specific ASGPR.

UCB-J is a radiolabeled oligomer used for positron emission tomography (PET), and it is a ligand for synaptic vesicle protein 2A (SV2A).

Udonitrectag (REC 0559) is a low molecular weight analogue of NGF that can improve the stability issues of NGF.

Vacquinol-1 (NSC13316) dihydrochloride is a specific activator of MKK4 that can activate the MAPK pathway. Vacquinol-1 dihydrochloride specifically induces death of human glioblastoma cells (GC), slows tumor progression, and prolongs survival in a mouse model of glioblastoma. Vacquinol-1 dihydrochloride also induces apoptosis in hepatocellular carcinoma (HCC) cells.

VL285 Phenol is a VL285 analog with a phenol group. VL285 is a small molecule VHL ligand that can act as a degrader in the synthesis of HaloPROTAC3. VL285 can degrade HaloTag7 fusion protein (IC50=0.34 μM).

Vutiglabridin (HSG4112) is a racemic compound and an effective anti-obesity agent. It is an optimized structural analog of glycyrrhizin with advantages in weight loss efficacy and chemical stability.