Others

PBD dimer-2 (compound 2c) is a pyrrolobenzodiazepine dimer connected by a C8 linker. PBD dimer-2 can span an extra base pair and crosslink the 5'-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can serve as an effective payload for antibody-drug conjugates (ADCs) and be used in cancer research.

PBR28 is a TSPO modulator that can be used for research on preventing pulmonary arterial hypertension (PAH). PBR28 can play an important role in brain positron emission tomography (PET) imaging studies by tracing 18 KDa translocator protein (TSPO) through increased radiolabeling.

PCAF-IN-1 is a highly selective inhibitor of PCAF. It is an anti-tumor active molecule that can be used for cancer research.

PDCD4-IN-1 (compound 20031600) is a PDCD4 inhibitor with a Kd value of 350 nM. It has a promoting effect on BDNF expression in hippocampal neuron cells HT-22.

PFB-FDGlu is a cell membrane-permeable fluorescent substrate specifically used for detecting glucocerebrosidase (GCase) activity in living cells.

PG-11047 (CGC-11047) is a polyamine analog. PG-11047 can be used for research on breast cancer.

Pheneturide (Ethylphenacemide, M 551) is a decarboxylation product of Phenobarbital and can be used to prevent psychomotor seizures.

PH-HG-005-5 can be used for ADC synthesis.

PhosTAC3 is a phosphorylation-targeted chimeric molecule (PhosTAC) consisting of a linker and three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a.

PhosTAC5 is a phosphorylation-targeted chimeric molecule (PhosTAC) consisting of a linker and five PEG groups. PhosTAC5 induces dephosphorylation of PDCD4 and FOXO3a.

(+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, and its in vivo target can be traced using 13C-serine. (+)SHIN2 increases the survival rate of mice with primary acute T-cell lymphoblastic leukemia (T-ALL) driven by Notch1 and has a synergistic effect with Methotrexate.

POLA1 inhibitor 1 (Compound 12) is an orally active inhibitor of POLA1. It exhibits anti-tumor activity against several types of tumor tissues and Adaroten-resistant cell lines.

Pomalidomide-5'-PEG5-C2-COOH is an active compound that can be used for various biochemical research purposes.

PRMT5:MEP50 PPI is a novel inhibitor of the protein-protein interaction (PPI) between PRMT5 and MEP50, which has anti-tumor activity and anti-proliferative activity against lung cancer and prostate cancer cells.

p-SCN-Bn-DOTA is a bifunctional chelator that can simultaneously chelate radioactive isotopes and link to monoclonal antibodies, making it useful for radioimmunotherapy research in cancer.

PSMA I&S (TFA) is a precursor of a 99mTc-labeled PSMA-targeting ligand.

QM295 is an endoplasmic reticulum oxidoreductase 1 (ERO1) inhibitor with selective reversible thiol reactivity. QM295 can be used for research on endoplasmic reticulum stress.

(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor with a 1,4-dihydropyran[2,3-c]pyrazole structure. It is involved in folate or one-carbon metabolism pathways and prevents viral infections. SHMT1 and SHMT2 are cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase respectively.

Rebaudioside O belongs to the stevioside category and can be isolated from S. Rebaudiana Morita , which was bred by S. Rebaudiana Bertoni , Rebaudioside O can be used as a sweetener.

RTC13 can restore the expression of dystrophin protein in the Duchenne muscular dystrophy (DMD) mdx mouse model and improve muscle function.

S07-2010 is an effective pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47 and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2 respectively. S07-2010 can induce apoptosis in A549/DDP cells. S07-2010 enhances the cytotoxicity of chemotherapeutic agents against drug-resistant cells and has a significant inhibitory effect on their proliferation.

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 value of 22.7 nM. S100P-IN-1 has anti-metastatic effects on pancreatic cancer cells.

S19-1035 is an efficient and specific inhibitor of aldo-keto reductase 1C3 (AKR1C3). S19-1035 inhibits AKR1C3 with an IC50 value of 3.04 nM. S19-1035 can be used for research on tumors.

SARM1-IN-2 is an inhibitor of SARM1 that can be used for research on axon degeneration. For more information, please refer to Example 82 in patent document WO2019236890A1.