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Startseite >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0.

Ziele für  Cell Cycle/Checkpoint

Produkte für  Cell Cycle/Checkpoint

  1. Bestell-Nr. Artikelname Informationen
  2. GC14060 CK 666 CK 666 ist ein zelldurchlässiger Actin-Related-Protein-Arp2/3-Komplex-Inhibitor (IC50\u003d12 μM). CK 666 Chemical Structure
  3. GC15076 CK 869

    CK-0157869

     CK 869 ist ein Actin-Related Protein 2/3 (ARP2/3)-Komplex-Inhibitor mit einem IC50-Wert von 7 μM. CK 869 Chemical Structure
  4. GC15894 CK-636

    CK-0944636

     CK-636 ist ein zellgÄngiger Inhibitor des Arp2/3-Komplexes, der die Aktinpolymerisation mit IC50-Werten von 4 μM, 24 μM und 32 μM fÜr Mensch, Spalthefe bzw. Rind hemmen kÖnnte. CK-636 Chemical Structure
  5. GC73395 Clathrin-IN-4 Clathrin-IN-4 (Verbindung 8b), ein Wiskostatin-Analogon, ist ein starker Hemmer der Clathrin-vermittelten Endozytose mit einem IC50 von 2,1 μM. Clathrin-IN-4 Chemical Structure
  6. GC43286 CMPD101 CMPD101 ist ein potenter, hochselektiver und membrangÄngiger niedermolekularer Inhibitor von GRK2/3 mit IC50 von 18 nM bzw. 5,4 nM. CMPD101 Chemical Structure
  7. GC49345 Coelenterazine hcp Coelenterazin hcp ist ein Coelenterazin-Analogon. Coelenterazine hcp Chemical Structure
  8. GC74600 Cofetuzumab pelidotin

    PF-06647020; ABBV-647; h6M24-vc0101

     Cofetuzumab pelidotin (PF-06647020) ist ein PTK7-Targeting ADC, bestehend aus einem humanisierten Anti-PTK7 mAb, verbunden mit einer Auristatin-Mikrotubuli-Inhibitor-Nutzlast, Auristatin-0101, durch einen spaltbaren Valin-Citrullin (vc)-basierten Linker. Cofetuzumab pelidotin Chemical Structure
  9. GC40664 Colcemid

    Demecolcine, NSC 3096

     Colcemid ist ein Zytoskelett-Inhibitor, der einen mitotischen Arrest in der G2/M-Phase oder einen meiotischen Arrest in der Phase der Vesikelruptur (GVBD) in Säugetierzellen bzw. Oozyten induziert. Colcemid Chemical Structure
  10. GC13261 Colchicine

    Ein Hemmstoff der Mikrotubuli-Polymerisation

     Colchicine Chemical Structure
  11. GC47117 Colchicine-d6 Colchicin-d6 ist das als Colchicin bezeichnete Deuterium. Colchicin ist ein Tubulin-Inhibitor und ein Wirkstoff, der die Mikrotubuli zerstÖrt. Colchicin hemmt die Mikrotubulipolymerisation mit einem IC50 von 3 nM. Colchicin ist auch ein kompetitiver Antagonist der α3-Glycinrezeptoren (GlyRs). Colchicine-d6 Chemical Structure
  12. GC43300 Combretastatin A1

    CA1

     Combretastatin A1 ist ein Inhibitor der Mikrotubuli-Polymerisation, der an die Colchicin-Bindungsstelle von Tubulin bindet. Combretastatin A1 hemmt den Wnt/β-Catenin-Weg durch Tubulin-Depolymerisations-vermittelte AKT-Deaktivierung. Combretastatin A1 zeigt Antitumor- und antivaskuläre Wirkungen. Combretastatin A1 Chemical Structure
  13. GC17631 Combretastatin A4

    CA4, Combretastatin A4, CRC 8709

     Combretastatin A4 ist ein auf Mikrotubuli zielender Wirkstoff, der β-Tubulin mit einer Kd von 0,4 μM bindet. Combretastatin A4 Chemical Structure
  14. GC43307 Concanamycin B

    8deethyl8methylConcanamycin A, MCH 210

     Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). Concanamycin B Chemical Structure
  15. GC43315 Corynecin IV Corynecin IV is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin IV Chemical Structure
  16. GC40663 Corynecin V Corynecin V is a chloramphenicol-like bacterial metabolite originally isolated from Corynebacterium. Corynecin V Chemical Structure
  17. GC63333 Cotosudil Cotosudil Chemical Structure
  18. GC16489 CP-466722 CP-466722 ist ein schnell reversibler Inhibitor von ATM mit einem IC50 von 4,1 μM und hat keine Auswirkungen auf PI3K oder eng verwandte Familienmitglieder der PI3K-Ähnlichen Proteinkinase (PIKK). CP-466722 Chemical Structure
  19. GC43321 CPTH6 (hydrobromide) CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. CPTH6 (hydrobromide) Chemical Structure
  20. GC19112 Crolibulin

    EPC2407

     Crolibulin (EPC2407) ist ein Tubulin-Polymerisationsinhibitor mit starker Apoptoseinduktion und Hemmung des Zellwachstums. Crolibulin hat Anti-Tumor-AktivitÄt. Crolibulin hat auch kardiovaskulÄre ToxizitÄt und NeurotoxizitÄt. Crolibulin Chemical Structure
  21. GC45414 CRT0066854 CRT0066854 ist ein potenter und selektiver atypischer PKC-Isoenzym-Inhibitor. CRT0066854 Chemical Structure
  22. GC40482 Curvulin Curvulin ist ein Phytotoxin. Curvulin Chemical Structure
  23. GC18028 CVT-313

    CVT 313;NG 26;CVT313;NG26;NG-26

     A Cdk2 inhibitor CVT-313 Chemical Structure
  24. GC11252 CW069 CW069 ist ein allosterischer Inhibitor des Mikrotubuli-Motorproteins HSET mit einem IC50 von 75 μM. CW069 Chemical Structure
  25. GC13268 Cyclapolin 9 Cyclapolin 9 ist ein potenter, selektiver und ATP-kompetitiver Polo-like-Kinase-1 (PLK1)-Inhibitor mit einem IC50 von 500 nM. Cyclapolin 9 ist gegenÜber anderen Kinasen inaktiv. Cyclapolin 9 Chemical Structure
  26. GC49709 cyclo(RGDyC) (trifluoroacetate salt)

    c(RGDyC), cyclo(Arg-Gly-Asp-D-Tyr-Cys)

     A cyclic pentapeptide cyclo(RGDyC) (trifluoroacetate salt) Chemical Structure
  27. GC43346 Cyclopamine-KAAD Cyclopamin-KAAD, ein Hedgehog-Signalweg-Inhibitor, ist ein geglÄtteter Antagonist. Cyclopamine-KAAD Chemical Structure
  28. GC47149 Cyclopiazonic Acid-13C20

    CPA-13C20

     A neuropeptide with diverse biological activities Cyclopiazonic Acid-13C20 Chemical Structure
  29. GC43351 Cylindrospermopsin

    Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease.

     Cylindrospermopsin Chemical Structure
  30. GC45877 CYM 5478 CYM 5478 ist ein potenter und hochselektiver S1P2-Agonist mit einem EC50-Wert von 119 nM in einem TGFα-Shedding-Assay. CYM 5478 Chemical Structure
  31. GC35789 Cys-mcMMAD Cys-mcMMAD ist ein Wirkstoff-Linker-Konjugat fÜr ADC. MMAD ist ein potenter Tubulin-Inhibitor. Cys-mcMMAD Chemical Structure
  32. GC68929 Cys-McMMAF

    Cys-McMMAF ist die von AlMcMMAF freigesetzte Wirkstofffracht. AlMcMMAF ist ein humanisierter A1-Antikörper gegen 5T4, der durch eine Maleimidopropyl-Verbindung mit dem Mikrotubuli-Zerstörer MMAF gekoppelt wird. Cys-McMMAF hat eine antitumoröse Wirkung auf zwei Maus-Tumor-Modelle (H1975 und MDA-MB-361-DYT2).

     Cys-McMMAF Chemical Structure
  33. GC43354 Cysmethynil

    Icmt Inhibitor

     Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Cysmethynil Chemical Structure
  34. GC11383 CYT997 (Lexibulin)

    Lexibulin

     CYT997 (Lexibulin) (CYT-997) ist ein potenter und oral aktiver Tubulin-Polymerisationshemmer mit IC50-Werten von 10-100 nM in Krebszelllinien; mit starker zytotoxischer und gefÄßzerstÖrender AktivitÄt in vitro und in vivo. CYT997 (Lexibulin) induziert Zellapoptose und induziert die mitochondriale ROS-Erzeugung in GC-Zellen. CYT997 (Lexibulin) Chemical Structure
  35. GC49863 Cytarabine 5′-monophosphate

    ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

     An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  36. GC45800 Cytarabine-13C3

    Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3

     A neuropeptide with diverse biological activities Cytarabine-13C3 Chemical Structure
  37. GC32890 Cytochalasin B (Phomin)

    NSC 107658, Phomin

     Cytochalasin B (Phomin) ist ein zellgÄngiges Mykotoxin, das an das mit Widerhaken versehene Ende von Aktinfilamenten bindet und die Bildung von Aktinpolymeren stÖrt, mit einem Kd-Wert von 1,4-2,2 nM fÜr F-Aktin. Cytochalasin B (Phomin) Chemical Structure
  38. GC13440 Cytochalasin D

    NSC 209835

     Cytochalasin D (Zygosporin A) ist ein potenter Actin-Polymerisationsinhibitor, der aus Pilzen gewonnen werden kÖnnte. Cytochalasin D Chemical Structure
  39. GC10870 Cytochalasin J alters mitotic spindle microtubule organization and kinetochore structure Cytochalasin J Chemical Structure
  40. GC43360 Cytostatin Cytostatin ist ein potenter und selektiver Inhibitor von PP2A mit vielversprechender AntitumoraktivitÄt. Cytostatin ist auch ein Inhibitor der ZelladhÄsion an die extrazellulÄre Matrix und induziert Zellapoptose. Cytostatin gehÖrt zur Naturstofffamilie der Fostriecine. Cytostatin Chemical Structure
  41. GC43361 Cytostatin (sodium salt) Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. Cytostatin (sodium salt) Chemical Structure
  42. GC91419 CYY292

    CYY292 ist ein Inhibitor von PDGFRα, PDGFRβ, FGFR1,-2 und -3 (IC50s = 5,35, 4,6, 28, 28 bzw. 78 nM).

     CYY292 Chemical Structure
  43. GC12384 D-64131

    D 64131;D64131

     An inhibitor of tubulin polymerization D-64131 Chemical Structure
  44. GC45419 D-chiro-Inositol 1,2,3,4,5,6-hexakisphosphate (sodium salt)   D-chiro-Inositol 1,2,3,4,5,6-hexakisphosphate (sodium salt) Chemical Structure
  45. GC40296 D-erythro-MAPP

    (1S,2RDerythro2Nmyristoylamino)1phenyl1propanol

     D-erythro-MAPP (D-e-MAPP) ist ein Ceramidase-Inhibitor mit einem IC50-Wert von 1-5 μM in vitro. D-erythro-MAPP Chemical Structure
  46. GC43506 D-myo-Inositol-1,2,3,5,6-pentaphosphate (sodium salt)

    Ins(1,2,3,5,6)-P5, 1,2,3,5,6-IP5

     D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K. D-myo-Inositol-1,2,3,5,6-pentaphosphate (sodium salt) Chemical Structure
  47. GC43507 D-myo-Inositol-1,2,3,5-tetraphosphate (sodium salt)

    Ins(1,2,3,5)P4 (sodium salt), 1,2,3,5IP4 (sodium salt)

     D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,2,3,5-tetraphosphate (sodium salt) Chemical Structure
  48. GC43509 D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt)

    Ins(1,2,4,5,6)P5 (sodium salt), 1,2,4,5,6IP5 (sodium salt)

     D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction. D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) Chemical Structure
  49. GC43510 D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt)

    Ins(1,2,4,5)P4, 1,2,4,5IP4

     Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals.. D-myo-Inositol-1,2,4,5-tetraphosphate (sodium salt) Chemical Structure
  50. GC43512 D-myo-Inositol-1,2,6-triphosphate (sodium salt)

    Ins(1,2,6)P3, 1,2,6IP3

     D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. D-myo-Inositol-1,2,6-triphosphate (sodium salt) Chemical Structure
  51. GC43513 D-myo-Inositol-1,2-diphosphate (sodium salt)

    Ins(1,2)P2 (sodium salt), 1,2IP2 (sodium salt)

     Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,2-diphosphate (sodium salt) Chemical Structure
  52. GC43514 D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)

    Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5 (sodium salt)

     Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt) Chemical Structure
  53. GC43515 D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)

    Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5

     The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents. D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt) Chemical Structure
  54. GC43516 D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)

    Ins(1,3,4,5)P4, 1,3,4,5IP4

     D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) Chemical Structure
  55. GC43517 D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)

    Ins(1,3,4,6)P4, 1,3,4,6IP4

     The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt) Chemical Structure
  56. GC43518 D-myo-Inositol-1,3,4-triphosphate (sodium salt)

    Ins(1,3,4)P3 (sodium salt), 1,3,4IP3 (sodium salt)

     The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals. D-myo-Inositol-1,3,4-triphosphate (sodium salt) Chemical Structure
  57. GC43519 D-myo-Inositol-1,3,5-triphosphate (sodium salt)

    Ins(1,3,5)P3 (sodium salt), 1,3,5IP3 (sodium salt)

     D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. D-myo-Inositol-1,3,5-triphosphate (sodium salt) Chemical Structure
  58. GC43520 D-myo-Inositol-1,3-diphosphate (sodium salt)

    Ins(1,3)P2 (sodium salt), 1,3-IP2 (sodium salt)

     D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,3-diphosphate (sodium salt) Chemical Structure
  59. GC43521 D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

    Ins(1,4,5,6)-P4

    D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction.

     D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Chemical Structure
  60. GC43522 D-myo-Inositol-1,4,5-triphosphate (potassium salt)

    Ins(1,4,5)P3 (potassium salt), 1,4,5IP3 (potassium salt)

     D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. D-myo-Inositol-1,4,5-triphosphate (potassium salt) Chemical Structure
  61. GC43523 D-myo-Inositol-1,4,5-triphosphate (sodium salt)

    Ins(1,4,5)P3

     Primary intracellular IP3 receptor agonist D-myo-Inositol-1,4,5-triphosphate (sodium salt) Chemical Structure
  62. GC43524 D-myo-Inositol-1,4,6-triphosphate (sodium salt)

    Ins(1,4,6)P3, 1,4,6IP3

     D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,4,6-triphosphate (sodium salt) Chemical Structure
  63. GC43525 D-myo-Inositol-1,4-diphosphate (sodium salt)

    Ins(1,4)P2 (sodium salt), 1,4IP2 (sodium salt)

     D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,4-diphosphate (sodium salt) Chemical Structure
  64. GC43526 D-myo-Inositol-1,5,6-triphosphate (sodium salt)

    Ins(1,5,6)P3 (sodium salt), 1,5,6IP3 (sodium salt)

     The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-triphosphate (sodium salt) Chemical Structure
  65. GC43527 D-myo-Inositol-1,5-diphosphate (sodium salt)

    Ins(1,5)P2, 1,5IP2

     D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-1,5-diphosphate (sodium salt) Chemical Structure
  66. GC43528 D-myo-Inositol-1-phosphate (cyclohexyl ammonium salt)

    Ins(1)P1 (cyclohexyl ammonium salt), 1IP1 (cyclohexyl ammonium salt)

     D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling. D-myo-Inositol-1-phosphate (cyclohexyl ammonium salt) Chemical Structure
  67. GC43529 D-myo-Inositol-1-phosphate (sodium salt)

    Ins(1)P1 (sodium salt), 1IP1 (sodium salt)

     D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals. D-myo-Inositol-1-phosphate (sodium salt) Chemical Structure
  68. GC43531 D-myo-Inositol-2,3,5,6-tetraphosphate (sodium salt)

    2,3,5,6IP4 (sodium salt), Ins(2,3,5,6)P4 (sodium salt)

     D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K. D-myo-Inositol-2,3,5,6-tetraphosphate (sodium salt) Chemical Structure
  69. GC43533 D-myo-Inositol-2,4,5-triphosphate (sodium salt)

    Ins(2,4,5)P3 (sodium salt), 2,4,5IP3 (sodium salt)

     The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-2,4,5-triphosphate (sodium salt) Chemical Structure
  70. GC43534 D-myo-Inositol-2,4-diphosphate (sodium salt)

    Ins(2,4)P2 (sodium salt), 2,4IP2 (sodium salt)

     The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, and motility. D-myo-Inositol-2,4-diphosphate (sodium salt) Chemical Structure
  71. GC43535 D-myo-Inositol-2,5,6-triphosphate (sodium salt)

    Ins(2,5,6)P3 (sodium salt), 2,5,6IP3 (sodium salt)

     Ins(2,5,6)P3 (sodium salt) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. D-myo-Inositol-2,5,6-triphosphate (sodium salt) Chemical Structure
  72. GC43536 D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)

    Ins(3,4,5,6)P4, 3,4,5,6IP4

     D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) (Ins(3,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt) Chemical Structure
  73. GC43537 D-myo-Inositol-3,4,5-triphosphate (sodium salt)

    Ins(3,4,5)P3, 3,4,5IP4

     D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)-P3) is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. D-myo-Inositol-3,4,5-triphosphate (sodium salt) Chemical Structure
  74. GC43538 D-myo-Inositol-3-phosphate (sodium salt)

    Ins(3)P1 (sodium salt), 3IP1 (sodium salt)

     D-myo-Inositol-3-phosphate (Ins(3)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals. D-myo-Inositol-3-phosphate (sodium salt) Chemical Structure
  75. GC43539 D-myo-Inositol-4,5-diphosphate (sodium salt)

    Ins(4,5)P2 (sodium salt), 4,5IP2 (sodium salt)

     D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. D-myo-Inositol-4,5-diphosphate (sodium salt) Chemical Structure
  76. GC43540 D-myo-Inositol-4-phosphate (ammonium salt)

    Ins(4)P1, 4IP1

     D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. D-myo-Inositol-4-phosphate (ammonium salt) Chemical Structure
  77. GC35797 D8-MMAD D8-MMAD Chemical Structure
  78. GC35798 D8-MMAF

    Monomethylauristatin F D8

     D8-MMAF-Hydrochlorid ist eine deuterierte Form von MMAF-Hydrochlorid. MMAF-Hydrochlorid, ein potenter Tubulin-Polymerisationsinhibitor, wird als Antitumormittel und als zytotoxische Komponente von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet. D8-MMAF Chemical Structure
  79. GC35799 D8-MMAF hydrochloride D8-MMAF hydrochloride Chemical Structure
  80. GC41305 DA-3003-2

    NSC 663285

     Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. DA-3003-2 Chemical Structure
  81. GC47164 Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2, (trifluoroacetate salt)

    MMP Fluorogenic Substrate III

     A neuropeptide with diverse biological activities Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2, (trifluoroacetate salt) Chemical Structure
  82. GC43369 Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 (trifluoroacetate salt) Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-3 (MMP-3). Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 (trifluoroacetate salt) Chemical Structure
  83. GC43370 Dabcyl-RGVVNASSRLA-EDANS (trifluoroacetate salt)

    Fluorogenic Human CMV Protease Substrate

     Dabcyl-RGVVNASSRLA-EDANS is a fluorogenic substrate for human cytomegalovirus (HCMV) protease. Dabcyl-RGVVNASSRLA-EDANS (trifluoroacetate salt) Chemical Structure
  84. GC18421 Dabcyl-YVADAPV-EDANS

    Dabcyl-ICE-EDANS

     Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1. Dabcyl-YVADAPV-EDANS Chemical Structure
  85. GC43371 Dabigatran Acyl-β-D-Glucuronide

    β-1-O-Acylglucuronide

    Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.

     Dabigatran Acyl-β-D-Glucuronide Chemical Structure
  86. GC47165 Dabigatran etexilate-d13 A neuropeptide with diverse biological activities Dabigatran etexilate-d13 Chemical Structure
  87. GC49684 Dabigatran-13C-d3

    BIBR 953-13C,d3; BIBR 953ZW-13C,d3

     An internal standard for the quantification of dabigatran Dabigatran-13C-d3 Chemical Structure
  88. GC49682 Dabigatran-d3

    BIBR 953-d3; BIBR 953ZW-d3

     An internal standard for the quantification of dabigatran Dabigatran-d3 Chemical Structure
  89. GC60120 Danicamtiv

    MYK-491, SAR440181

     Danicamtiv (MYK-491), ein inotropes Mittel, ist ein selektiver allosterischer Aktivator von Herzmyosin. Danicamtiv erhÖht die kardiale systolische Funktion und bewahrt die mechanische Effizienz. Danicamtiv Chemical Structure
  90. GC43377 Daphnoretin Daphnoretin is a coumarin that has been found in W. Daphnoretin Chemical Structure
  91. GC43379 Darinaparsin

    Dimethylarsinic glutathione

     Darinaparsin (ZIO-101), ein organisches Arsen, ist ein auf die Mitochondrien gerichteter Wirkstoff. Darinaparsin induziert Apoptose in Krebszellen und hat Antikrebswirkungen. Darinaparsin Chemical Structure
  92. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride Chemical Structure
  93. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

     A neuroprotective ADNP-derived peptide Davunetide (acetate) Chemical Structure
  94. GC74061 DBM-C5-VC-PAB-MMAE DBM-C5-VC-PAB-MMAE (Verbindung 3a) ist ein Drug-Linker-Konjugat für ADC. DBM-C5-VC-PAB-MMAE Chemical Structure
  95. GC74000 DBPR728 DBPR728 ist ein Acylprodrug von 6K465, der weniger Drogenbindungsspender trägt. DBPR728 Chemical Structure
  96. GC43385 DC-Chol (hydrochloride)

    ​Cholesteryl 3β-N-(dimethylaminoethyl)carbamate

     DC-Chol (hydrochloride) kann die Bildung von Aβ40-Fasern hemmen, DC-Chol (Hydrochlorid) kann die Amyloidbildung von oxidiertem hCT hemmen. DC-Chol (hydrochloride) Chemical Structure
  97. GC39486 DCLK1-IN-1 DCLK1-IN-1 ist eine selektive, orale BioverfÜgbarkeit in vivo-kompatible chemische Sonde der Doppelcortin-Ähnlichen Kinase 1 (DCLK1-Kinase)-DomÄne. DCLK1-IN-1 hemmt DCLK1- und DCLK2-Kinasen (IC50: DCLK1 =9,5/57,2 nM und DCLK2 =31/103 nM im Bindungs- bzw. Kinase-Assay). DCLK1-IN-1 zeigt eine geringe ToxizitÄt und kann die DCLK1-Biologie untersuchen und seine Rolle bei Krebs wie DCLK1+ duktales Adenokarzinom des Pankreas (PDAC) bestimmen. DCLK1-IN-1 Chemical Structure
  98. GN10426 Deacetyltaxol

    10-DAP, 10-Deacetyltaxol

     Deacetyltaxol Chemical Structure
  99. GC92030 Debio 0123 (hydrochloride)

    WEE1-IN-5; WEE1 Inhibitor 5

     Debio 0123 (hydrochloride) ist ein Inhibitor der Checkpoint Kinase WEE1 IC50,0,8 nM. Debio 0123 (hydrochloride) Chemical Structure
  100. GC18666 Debromohymenialdisine

    DBH, SKF 108753

     Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine Chemical Structure
  101. GC11835 Deferasirox

    ICL 670

     Deferasirox (ICL 670) ist ein oral verfÜgbarer Eisenchelator, der zur Behandlung einer transfusionsbedingten EisenÜberladung eingesetzt wird. Deferasirox Chemical Structure

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